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Zissimos Mourelatos, M.D.

Professor of Pathology and Laboratory Medicine
Fellowship Director, Neuropathology, Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology and Laboratory Medicine
Division of Neuropathology
613B Stellar Chance Labs
422 Curie Boulevard
Philadelphia, PA 19104-6100
Office: 215-746-0014
Fax: 215-746-0285
Graduate Group Affiliations
Education:
M.D.
Aristotelian University of Thessaloniki - School of Medicine, Thessaloniki, Greece, 1991.
Post-Graduate Training
Clinical Student Fellowship, A.U.TH, A' Neurology Clinic, Thessaloniki, Greece. , 1988-1989.
Research Student Fellowship, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A. , 1989-1989.
ERASMUS-E.C.T.S. Clinical Student Scholarship: , Universite Libre de Bruxelles, School of Medicine, Brussels, Belgium, 1990-1990.
Resident in Anatomic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1995-1997.
Fellow in Neuropathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1997-1999.
Certifications
American Board of Pathology (Board Certified in Anatomic Pathology and Neuropathology), 1999.
Permanent link
 
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Description of Research Expertise

Biochemical and genetic studies of Ribonucleoproteins (RNPs) with emphasis on
small regulatory RNPs such as microRNAs (miRNAs) and piRNAs (Piwi-associated RNAs).
Biochemical and genetic studies of mRNA translation and mRNA decay.
Biochemical and genetic studies of RNA dysregulation in the pathogenesis of neurodegeneration.

Description of Clinical Expertise

Neuropathology
Surgical Neuropathology (Brain tumors; Brain biopsies; Muscle biopsies; Nerve biopsies)
Medical Neuropathology

Description of Other Expertise

Director, Division of Neuropathology
Fellowship Director, Neuropathology

Selected Publications

Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee V-MY, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD: Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum Molec Genet 21(13): 2899-911, Jul 2012.

Liu X, Jin D-Y, McManus MT, Mourelatos Z: Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell 46(4): 507-17, May 2012.

Vourekas A, Zheng Q, Alexiou P, Maragkakis M, Kirino Y, Gregory BD, Mourelatos Z : Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nat Struct Mol Biol 19(8): 773-81, Aug 2012.

Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena CS, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ: Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity. J Neurol Sci 301(1-2): 112-5, Feb 2011.

Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD: A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci USA 108(52): 20881-90, Dec 2011.

Venneti S, Boateng LA, Friedman JR, Baldwin DA, Tobias JW, Judkins AR, Mourelatos Z, Priti L: MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. Brain Pathol 22(4): 522-9, Jul 2012.

Kirino Y, Vourekas A, Khandros E, Mourelatos Z: Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs. Methods Mol Biol 725: 281-93, 2011.

de Planell-Saguer M, Rodicio MC, Mourelatos Z: Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment. Nat Protoc 5(6): 1061-73, May 2010.

Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z: Arginine methylation of vasa protein is conserved across phyla. J Biol Chem 285(11): 8148-54, Mar 2010.

Kirino A, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z : Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA 16(1): 70-8, Jan 2010.

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Last updated: 07/19/2017
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