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Nicholas K. Gonatas, M.D.

Department: Pathology and Laboratory Medicine

Contact information
University of Pennsylvania Medical Center
609 Stellar Chance Bldg.
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: 215-662-6695
Fax: 215-898-9969
Anatolia College, Thessaloniki, Greece, 1946.
Thessaloniki University Medical School, Greece, 1952.
Post-Graduate Training
Straight Internship in Internal Medicine, Jersey City Medical Center, Jersey City, NJ, 1956-1957.
Resident and Chief Resident in Pathology, Montefiore Hospital, New York, NY, 1957-1961.
Postdoctoral Fellow, NINDB and Assistant Professor, Department of Pathology, Albert Einstein College of Medicine, 1962-1963.
American Board of Pathologic Anatomy, 1961.
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> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Stieber A, Gonatas JO, Moore JS, Bantly A, Yim HS, Yim MB, Gonatas NK: Disruption of the structure of the Golgi apparatus and the function of the secretory pathway by G93A and G85R of Cu,Zn superoxide dismutase (SOD1) of familial amyotrophic lateral sclerosis. J Neuorl Sci 219(1-2): 45-53, Apr 2004.

Gilchrist CA, Gray DA, Stieber A, Gonatas NK, Kopito R: Effect of ubiquitin expression on neuropathogenesis in a mouse model of familial amyotrophic lateral sclerosis. Neuropathology and Applied Neurobiology 31(1): 20-33, Feb 2005.

Strey CW, Spellman D, Stieber A, Gonatas JO, Wang X, Lambris JD, Gonatas NK: Dysregulation of stathmin, a microtubule destabilizing protein, and up-regulation of Hsp25, Hsp27 and the anti-oxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Am J Pathol 165(5): 1701-18, Nov 2004.

Yaguchi A, Hashizume Y, Yoshida M, Gonatas NK, Okamoto K: Reduction of the size of the Golgi apparatus of spinal anterior horn cells in patients with X-linked spinal and bulbar muscular atrophy. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 4: 17-21, 2003.

Yamaguchi F, Morrison RS, Gonatas NK, Takahashi H, Sugisaki Y, Teramoto A: Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: An index of malignancy inastrocytomas. Intern J Oncol 22(5): 1045-9, May 2003.

Fujita Y, Okamoto K, Sakurai A, Kusaka H, Aizawa H, Mihara B, Gonatas NK: The Golgi apparatsus is fragmented in spinal cord motor neurons of amyotrophic lateral sclerosis with basophilic inclusions. Acta Neuropath 103(3): 243-7, Mar 2002.

Sakurai A, Okamoto K, Yaguchi M, Fujita Y, Nakazato Y, Gonatas NK: Pathology of the inferior olivary nuclei in patients with multiple system atrophy. Acta Neuropathologica 103(6): 550-4, Jun 2002.

Uesugi M, Okamoto K, Tanaka M, Gonatas NK: Masses of phosphorylated neurofilaments are associated with abnormal Golgi apparatus of anterior horn neurons of B,B'-imidipropionitrile-intoxicated rats. Neuropathology 22(2): 61-5, Jun 2002.

Stieber A, Gonatas JO, Collard JF, Meier J, Julien J-P, Schweitzer P, Gonatas NK: The neuronal Golgi apparatus is fragmented in transgenic mice expressing a mutant human SOD1, but not in mice expressing the human NF-H gene. J Neurol Sci 173(1): 63-72, Feb 2000.

Stieber A, Gonatas JO, Gonatas NK: Aggregation of ubiquitin and a mutant ALS-linked SOD1 protein correlate with disease progression and fragmentation of the Golgi apparatus. J Neurol Sci 173(1): 53-62, Feb 2000.

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Last updated: 06/30/2011
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