Penn Comprehensive Neuroscience Center

Faculty Members
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John Q. Trojanowski

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Director, National Institute of Neurological Disorders & Stroke Morris K. Udall Parkinson’s Disease Research Center of Excellence, University of Pennsylvania School of Medicine
Department: Pathology and Laboratory Medicine

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Graduate Group Affiliations
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
M.D.
Tufts University School of Medicine, 1976.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
Post-Graduate Training
Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977.
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979.
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA , 1979-1980.
Certifications
American Board of Pathology, Anatomic Pathology and Neuropathology National Board of Medical Examiners - No. 138521 , 1981.
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Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Description of Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Lee, E.B., Zhang, B., Liu, K., Greenbaum, E., Doms, R.W., Trojanowski, J.Q., and Lee, V.M.-Y. : BACE overexpression alters the subcellular processing of APP and inhibits A (beta) deposition in vivo. J Cell Biol 168: 291-302, 2005.

Kotzbauer, P.T., Truax, A., Trojanowski, J.Q., Lee, V.M.-Y. : Altered neuronal mitochondrial coenzyme a synthesis in Neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2. J Neurosci 25: 689-698, 2005.

Liang, T.-W., Forman, M.S., Duda, J.E., McCluskey, L., Trojanowski, J.Q., Siderowf, A.: Multiple Pathologies in a Patient with a Rapidly Progressive Neurodegenerative Syndrome. J. Neurol Neurosurg Psychiat 76: 252-255, 2005.

Roy, S., Zhang, B., Lee, V.M.-Y., Trojanowski, J.Q.: Axonal Transport Defects: A Common Theme in Neurodegenerative Diseases. Acta Neuropathol, (Epub ahead of print) 2005.

Bodner, S.M., Berrettini, W., Van Deerlin, V., Bennett, D.A., Wilson, R.S., Trojanowski, J.Q., Arnold, S. E. : Genetic Variation in the Brain Derived Neurotrophic Factor Gene in Alzheimer’s Disease. Amer J Med Genet B Neuropsychiatry Genet, (Epub ahead of print) 2005.

Zhang, B., Maiti, A., Shively, S., Lakhani, F., McDonald-Jones, G., Bruce, J., Lee, E.B., Xie, S.X., Joyce, S., Li, C., Toleikis, P.M., Lee, V.M.-Y., Trojanowski, J.Q.: Microtubule binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc Natl Acad Sci USA 102: 227-231, 2005.

Yazawa, I., Giasson, B.I., Sasaki, R., Zhang, B., Joyce, S., Uryu, K., Trojanowski, J.Q., Lee, V.M.-Y.: Mouse Model of Multiple System Atrophy: alpha-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration. Neuron 45: 1-13, 2005.

Geerts, H., Trojanowski, J.Q., Lee, V.M.-Y.: Drug discovery in neurodegenerative diseases. Sci Aging Knowledge Environ. 2005 Feb 09;2005(6):pe4. PMID: 15703448 (PubMed – in process) 2005.

Pickering-Brown, S., Baker, M., Bird, T., Trojanowski, J.Q., Lee, V.M.-Y., Morris, H., Rosser, M., Jannsen, J., Neary, D., Craufurd, D., Richardson, A., Snowden, J., Hardy, J., Mann, D., Hutton, M. : Evidence of a founder effect in families of frontotemporal dementia that harbour the tau +16 splice mutation Am J Med Genetics 125B: 79-82, 2004.

Zhukareva, V., Trojanowski, J.Q., Lee, V.M.-Y.: Assessment of pathological tau proteins in frontotemporal dementias: Qualtitative and quantitative approaches. Am J Geriatric Psychiat 12: 136-145, 2004.

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Last updated: 01/17/2014
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