Penn Comprehensive Neuroscience Center

Faculty Members
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R. Nick Bryan, M.D., Ph.D

Emeritus Professor of Radiology
Department: Radiology

Contact information
104 Surgeon General Court
Philadelphia, PA 19146
Office: 215-662-3660
Fax: 215-615-3681
Johns Hopkins University, 1965.
M.D. (Medicine)
University of Texas Medical Branch, Galveston, Texas, 1969.
Ph.D. (Anatomy)
University of Texas Medical Branch, Galveston, TX, 1973.
Post-Graduate Training
Internship: Rotating/Radiology, University of Texas Medical Branch, Galveston, Texas, 1969-1970.
Fellowship in Neuroanatomy: NIH Postdoctoral with Dr. W.D. Willis, Marine Biomedical Institute, 1970-1971.
Radiology Residency, University of Texas Medical Branch, Galveston, Texas, 1971-1973.
NIH Special Fellow (Neuroradiology), Neurological Institute of New York, NYC , 1973-1974.
Diagnostic Radiology (Neuroradiology, 1995), 1974.
American Board of Radiology Certification of Added Qualifications (CAQ) - Neuroradiology, 1995.
American Board of Radiology (MOC) - Neuroradiology, 2004.
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Description of Research Expertise

Cerebral MRI findings and cognitive functioning; applications of perfusion MRI for neurological studies; development of spatially-oriented databases for digital brain images; nuclear magnetic resonance evaluation of stroke; physiologic imaging of human brain tumors.

Description of Clinical Expertise


Selected Publications

Bryan RN, Jacobs DR, Zhu N, Schreiner PJ, Launer L, Whitmer R, Sidney S, Demerath E, Thomas W, Bouchard C, He K, Guray E, Harsha B.: Cardiorespiratory fitness in relation to brain volume and white matter integrity and blood flow: The CARDIA Study. Neurology 2: 123, September 2014.

Barzilay J, Morgan T, Murray A, Bryan RN, William J, Schnall A, Launer L.: Brain MRI Findings in Diabetic Adults with Albuminuria The ACCORD MIND Study. Clinical Journal of the American Society of Nephrology September 2014.

Zi Zhang, MD, MSCE; James Lovato, MS; Harsha Battapady, MS BME; Christos Davatzikos, PhD; Hertzel C. Gerstein, MD, MSc; Faramarz Ismail-Beigi, MD, PhD; Lenore J. Launer, PhD; Anne Murray, MD, MS; Zubin Punthakee, MD; Amilcar A. Tirado, MD; Jeff Williamson, MD; R. Nick Bryan, MD, PhD; Michael E. Miller, PhD. : Effect of Hypoglycemia on Brain Structure in People with Type 2 Diabetes: Epidemiological Analysis of the ACCORD-MIND MRI Trial. Diabetes Care September 2014.

Hugenschmidt Christina E, Lovato James F, Ambrosius Walter T, Bryan R Nick, Gerstein Hertzel C, Horowitz Karen R, Launer Lenore J, Lazar Ronald M, Murray Anne M, Chew Emily Y, Danis Ronald P, Williamson Jeff D, Miller Michael E, Ding Jingzhong: The Cross-Sectional and Longitudinal Associations of Diabetic Retinopathy With Cognitive Function and Brain MRI Findings: The Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial. Diabetes care September 2014.

Benjamin F.J. Verhaaren*, MD, PhD; Stéphanie Debette*, MD, PhD; Joshua C. Bis*, PhD; Jennifer A. Smith*, PhD, MPH, MA; M. Kamran Ikram MD, PhD; Hieab H. Adams, MSc; Ashley H. Beecham, MSc; van Buchem, MD, PhD; Jeroen van der Grond, PhD; Albert V. Smith, PhD; Katrin Hegenscheid, MD; Neelum T. Aggarwal, MD; Mariza de Andrade, PhD; Elizabeth J. Atkinson, PhD; Marian Beekman, PhD; Alexa S. Beiser, PhD; Susan H. Blanton, PhD; Eric Boerwinkle, PhD; Adam M. Brickman PhD; R. Nick Bryan MD, PhD; Ganesh Chauhan, PhD; Christopher P.L.H. Chen, FRCP; Vincent Chouraki MD, PhD; Anton J.M. de Craen, PhD; Fabrice Crivello, PhD; Mary Cushman MD, MSc; Ian J. Deary, PhD; Joris Deelen, MSc; Philip L. deJager MD, PhD; Carole Dufouil, PhD; Mitchell S.V. Elkind, MD, MSc;33 Denis A. Evans MD;13 Paul Freudenberger, MSc;34 Rebecca F. Gottesman, MD, PhD;35 Vilmundur Guðnason, MD, PhD; Mohamad Habes, PhD; Susan R. Heckbert MD, PhD; Gerardo Heiss, MD; Saima Hilal, MBBS; Edith Hofer, PhD; Albert Hofman, MD, PhD; Carla A. Ibrahim-Verbaas, MD; Wouter J. Jukema, MD, PhD; David S. Knopman, MD; Cora E. Lewis MD, MSPH; Jiemin Liao, MSc; David C.M. Liewald, BSc; Michelle Luciano, PhD; Aad van der Lugt, MD, PhD; Oliver O. Martinez, PhD; Richard Mayeux MD, MSc; Bernard Mazoyer, MD, PhD; Mike Nalls, PhD; Matthias Nauck, MD; Wiro J. Niessen, PhD; Ben A. Oostra, PhD; Bruce M. Psaty, MD, PhD; Kenneth M. Rice, PhD; Jerome I. Rotter, MD; Bettina von Sarnowski, MD; Helena Schmidt, MD, PhD; Pamela J. Schreiner, PhD; Maaike Schuur, MD, PhD; Stephen S. Sidney, MD, MPH; Sigurdur Sigurdsson, MSc; P. Eline Slagboom, PhD; David J.M. Stott, MD; John C. van Swieten, MD, PhD; Alexander Teumer, PhD; Anna Maria Töglhofer, MSc; Matthew Traylor, MSc; S. Trompet, PhD; Stephen T. Turner, MD; Christophe Tzourio, MD, PhD; Hae-Won Uh, PhD; André G. Uitterlinden, PhD; Meike W. Vernooij, MD, PhD; Jing J. Wang, PhD; Tien Y. Wong, MD, PhD; Joanna M. Wardlaw, MD; B. Gwen Windham, MD; Katharina Wittfeld; Christiane Wolf, PhD; Clinton B. Wright, MD; Qiong Yang, PhD; Wei Zhao, MD, PhD; Alex Zijdenbos, PhD; Ralph L. Sacco, MD; Sharon L.R. Kardia, PhD; Philippe Amouyel, MD, PhD; Thomas H. Mosley, PhD; W. T. Longstreth, Jr, MD, MPH; Charles C. DeCarli, MD; Cornelia M. van Duijn, PhD; Reinhold Schmidt, MD; Lenore J. Launer, PhD; Hans J. Grabe*, MD; Sudha S. Seshadri, MD; M. Arfan Ikram*, MD, PhD; Myriam Fornage*, PhD;: Multiethnic genomewide association study of cerebral white matter lesions on MRI. Annals of Neurology July 2014.

Laura H Coker, Mark A Espeland, Patricia E Hogan, Susan M Resnick, R Nick Bryan, Jennifer G Robinson, Joseph S Goveas, Christos Davatzikos, Lewis H Kuller, Jeff D Williamson, Cheryl D Bushnell, and Sally A Shumaker : Change in Brain and Lesion Volumes Following CEE Therapies: The WHIMS MRI Studies NEUROLOGY 82(5): 427-34, February 2014.

Rapp SR, Espeland ME, Manson JE, Resnick SM, Bryan NR, Smoller S, Coker LH, Phillips LS, Stefanick ML, and Sarto GE for the Women’s Health Initiative Memory Study.: Educational attainment, MRI changes and cognitive function in older postmenopausal women from the Women’s Health Initiative Memory Study. International J Psychiatry in Medicine 46(2): 119-141, 2014.

Mark D. Sullivan, MD, PhD;Wayne J. Katon, MD; Laura C. Lovato, MA; Michael E. Miller, PhD; Anne M. Murray, MD; Karen R. Horowitz, MD; R. Nick Bryan, MD; Hertzel C. Gerstein, MD; Santica Marcovina, MD; Basil E. Akpunonu, MD; Janice Johnson, BA; Jean Francois Yale, MD; Jeff Williamson, MD; Lenore J. Launer, PhD: Association of Depression With Accelerated Cognitive Decline Among Patients With Type 2 Diabetes in the ACCORD-MIND Trial. JAMA Psychiatry 70(10): 1041-1047, October 2013.

Halstead, M and Bryan, R.N.: Young to Middle Age 25 Year Pulse Pressure Trajectories and the Brain: The Coronary Artery Risk Development in Young Adults (CARDIA) Brain Study. 6th International Society of Vascular Behavioural and Cognitive Disorders (VAS COG) June 2013.

Tanwar, M, Herskovits, E H, Nasrallah, I M, Kundel, H, Mohan, S, Li, C, Lynch, M C, Bryan, R N : Evaluation of a Bayesian Expert System for Aiding Neuroradiology Diagnoses: A Pilot Study. American Society of Neuroradiology Annual Meeting. May 2013.

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Last updated: 11/12/2014
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