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Faculty Members: 
Zissimos Mourelatos, M.D.
Associate Professor of Pathology and Laboratory Medicine
Fellowship Director, Neuropathology, Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact information
Department of Pathology and Laboratory Medicine
Division of Neuropathology
613B Stellar Chance Labs
422 Curie Boulevard
Philadelphia, PA 19104-6100
Division of Neuropathology
613B Stellar Chance Labs
422 Curie Boulevard
Philadelphia, PA 19104-6100
Office: 215-746-0014
Fax: 215-746-0285
Fax: 215-746-0285
Email:
mourelaz@uphs.upenn.edu
mourelaz@uphs.upenn.edu
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
Primary Work Website
Cell and Molecular Biology graduate group webpage.
Search PubMed for articles
Primary Work Website
Cell and Molecular Biology graduate group webpage.
Education:
M.D.
Aristotelian University of Thessaloniki - School of Medicine, Thessaloniki, Greece, 1991.
M.D.
Aristotelian University of Thessaloniki - School of Medicine, Thessaloniki, Greece, 1991.
Post-Graduate Training
Clinical Student Fellowship, A.U.TH, A' Neurology Clinic, Thessaloniki, Greece. , 1988-1989.
Research Student Fellowship, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A. , 1989-1989.
ERASMUS-E.C.T.S. Clinical Student Scholarship: , Universite Libre de Bruxelles, School of Medicine, Brussels, Belgium, 1990-1990.
Resident in Anatomic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1995-1997.
Fellow in Neuropathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1997-1999.
Clinical Student Fellowship, A.U.TH, A' Neurology Clinic, Thessaloniki, Greece. , 1988-1989.
Research Student Fellowship, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A. , 1989-1989.
ERASMUS-E.C.T.S. Clinical Student Scholarship: , Universite Libre de Bruxelles, School of Medicine, Brussels, Belgium, 1990-1990.
Resident in Anatomic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1995-1997.
Fellow in Neuropathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1997-1999.
Certifications
American Board of Pathology (Board Certified in Anatomic Pathology and Neuropathology), 1999.
Permanent linkAmerican Board of Pathology (Board Certified in Anatomic Pathology and Neuropathology), 1999.
Description of Research Expertise
Biochemical and genetic studies of small regulatory RNAs usch as microRNAs (miRNAs) and piRNAs (Piwi-associated RNAs).Biochemical and genetic studies of RNA dysregulation in the pathogenesis of neurodegeneration
Description of Clinical Expertise
NeuropathologySurgical Neuropathology (Brain tumors; Brain biopsies; Muscle biopsies; Nerve biopsies)
Medical Neuropathology
Selected Publications
Couthouis J., Hart M.P., Erion R., King O.D., Diaz Z., Nakaya T., Ibrahim F., Kim H.J., Mojsilovic-Petrovic J., Panossian S., Kim C.E., Frackelton E.C., Solski J.A., Williams K.L., Clay-Falcone D., Elman L., McCluskey L., Greene R., Hakonarson H., Kalb R.G., Lee V-MY, Trojanowski J.Q., Nicholson G.A., Blair I.P., Bonini N.M., Van Deerlin V.M., Mourelatos Z. ,Shorter J and A.D. Gitler: Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics 21: 2899-911, 2012.Liu X., Jin D-Y, McManus M.T. and Z. Mourelatos: Precursor MicroRNA-Programmed Silencing Complex Assembly Pathways in Mammals. Molecular Cell 46: 507-17, 2012.
Vourekas, A, Zheng Q., Kirino Y., Alexiou P., Maragkakis, M., Gregory B.D. and Z. Mourelatos : Target RNA repertoire of Mili and Miwi reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nature Structural & Molecular Biology 19: 773-81, 2012.
Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena CS, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ : Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity. Journal of the Neurological Sciences 301(1-2): 112-5, Feb 2011.
Couthouis J., Erion R., Hart M.P., Oristano R.E., Liu X.A., Ramos D., Jethava N., Hosangadi D., Epstein J., Chiang A., Diaz Z., Nakaya T., Ibrahim F., King O.D., , Kim H.J., Panossian S., Kim C.E., Frackelton E.C., Geser F., Clay-Falcone D., Elman L., McCluskey L., Greene R., Lee V-MY, Trojanowski J.Q., Hakonarson H., Bonini N.M., Shorter J., Van Deerlin V.M., Mourelatos Z. and A.D. Gitler: A yeast functional screen predicts new candidate ALS disease genes. PNAS 108: 20881-90, 2011.
Venneti S., Boateng L.A., Friedman J.R, Baldwin D.A., Tobias J.W., Judkins A.R., Mourelatos Z. and L. Priti.: MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. Brain Pathology 22(4): 522-9, 2012.
Kirino Y, Vourekas A, Khandros E, Mourelatos Z: Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs. Methods Molecular Biology 725: 281-93, 2011.
de Planell-Saguer M, Rodicio MC, Mourelatos Z: Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment. Nature Protocols 5(6): 1061-73, May 2010.
Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z: Arginine methylation of vasa protein is conserved across phyla. J Biol Chem 285(11): 8148-54, Mar 2010.
Kirino A, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, and Mourelatos Z : Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA 16(1): 70-8, Jan 2010.
