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Faculty Members:
Nicholas K. Gonatas, M.D.
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
University of Pennsylvania Medical Center
609 Stellar-Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104-6100
609 Stellar-Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: 2156626695
Fax: 2155732059
Fax: 2155732059
Email:
GONATASN@MAIL.MED.UPENN.EDU
GONATASN@MAIL.MED.UPENN.EDU
Publications
Education:
B.A.
Anatolia College, Thessaloniki, Greece, 1946.
M.D.
Thessaloniki University Medical School, Greece, 1952.
B.A.
Anatolia College, Thessaloniki, Greece, 1946.
M.D.
Thessaloniki University Medical School, Greece, 1952.
Post-Graduate Training
Straight internship in Internal Medicine, Jersey City Medical Center, Jersey City, NJ, 1956-1957.
Resident and Chief Resident in Pathology, Montefiore Hospital, New York, NY, 1957-1961.
Postdoctoral Fellow, NINDB and Assistant Professor, Department of Pathology, Albert Einstein College of Medicine, 1962-1963.
Straight internship in Internal Medicine, Jersey City Medical Center, Jersey City, NJ, 1956-1957.
Resident and Chief Resident in Pathology, Montefiore Hospital, New York, NY, 1957-1961.
Postdoctoral Fellow, NINDB and Assistant Professor, Department of Pathology, Albert Einstein College of Medicine, 1962-1963.
Certifications
American Board of Pathologic Anatomy, 1961.
Permanent linkAmerican Board of Pathologic Anatomy, 1961.
Selected Publications
Stieber, A., Gonatas, J.O., Moore, J.S., Bantly, A., Yim, H-S., Gonatas, N.K.: Fragmentation of the Golgi apparatus, dysfunction of the secretory pathway and decreased survival of cells expressing mutants of Cu,Zn superoxide dismutase (SOD1) of familial amyotrophic lateral sclerosis. J. Neuorl. Sci. 219: 45-53, 2004.Gilchrist, C.A., Gray, D.A., Stieber, A., Gonatas, N.K., and Kopito, R.: Effect of ubiquitin expression on neuropathogenesis in a mouse model of amyotrophic lateral sclerosis. Neuropathology and Applied Neurobiology Page: In Press, 2004.
Strey, C.W., Spellman, D., Stieber, A., Gonatas, J.O., Wang, X., Lambris, J.D., Gonatas, N.K.: Dys-regulation of Stathmin, a microtubule depolymerizing protein, and up-regulation of Hsp25, Hsp27 and the anti-oxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Am. J. Pathol. 165: 1701-1808, 2004.
Yaguchi, A., Hashizume, Y., Yoshida, M., Gonatas, N.K., and Okamoto, K.: Reduction of the size of the Golgi apparatus of spinal anterior horn cells in patients with X-linked spinal and bulbar muscular atrophy. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 4: 17-21, 2003.
Yamaguchi, F., Morrison, R.S., Gonatas, N.K., Takahashi, H., Sugisaki, Y., Teramoto, A.: Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: An index of malignancy inastrocytomas. Intern. J. Oncol. 22: 1045-1049, 2003.
Fujita, Y., Okamoto, K., Sakurai, A., Kusaka, H., Aizawa, H., Mihara, B., and Gonatas, N.K.: The Golgi apparatsus is fragmented in spinal cord motor neurons of amyotrophic lateral sclerosis with basophilic inclusions. Acta Neuropath. 103: 243-247, 2002.
Sakurai, A., Okamoto, K., Yaguchi, M., Fujita, Y., Nakazato, Y., and Gonatas, N.K.: Pathology of the inferior olivary nuclei in patients with multiple system atrophy. Acta Neuropathologica 103: 550-554, 2002.
Uesugi, M., Okamoto, K., Tanaka, M., Gonatas, N.K.: Masses of phosphorylated neurofilaments are associated with abnormal Golgi apparatus of anterior horn neurons of B,B'-imidipropionitrile-intoxicated rats. Neuropathology 22: 61-65, 2002.
Stieber, A., Gonatas, J.O., Collard, J.F, Meier, J., Julien, J-P, Schweitzer, P., and Gonatas, N.K.: The neuronal Golgi apparatus is fragmented in transgenic mice expressing a mutant human SOD1, but not in mice expressing the human NF-H gene. J. Neurol. Sci. 173: 63-72, 2000.
Stieber, A., Gonatas, J.O., and Gonatas, N.K.: Aggregation of ubiquitin and a mutant ALS-linked SOD1 protein correlate with disease progression and fragmentation of the Golgi apparatus. J. Neurol. Sci. 173: 53-62, 2000.
