Penn Comprehensive Neuroscience Center

Faculty Members
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Eric L. Zager, MD, FACS, FAANS

Professor of Neurosurgery at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania , Hospital of the University of Pennsylvania
Attending Physician, Children’s Hospital of Philadelphia, Children’s Hospital of Philadelphia
Attending Physician, Pennsylvania Hospital, Pennsylvania Hospital
Member, Executive Committee, Department of Neurosurgery, University of Pennsylvania Medical Center
Medical Director, Neurosurgical Intensive Care Unit, HUP
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3497
Fax: 215-349-5534
Education:
B.A. (Biochemistry)
Harvard College, 1977.
M.D.
Stanford University, 1982.
Post-Graduate Training
Intern in General Surgery, Columbia-Presbyterian Medical Center, New York, 1982-1983.
Resident in Neurosurgery, Massachusetts General Hospital, Boston, 1983-1988.
Fellow, Peripheral Nerve Surgery, University of Toronto, Ontario, Canada, 1989-1989.
Fellow, Peripheral Nerve Surgery, LSU Medical Center, New Orleans, 1989-1989.
Certifications
American Board of Neurological Surgery, 1992.
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Description of Research Expertise

Clinical/translational research focuses on peripheral nerve repair and regeneration, as well as a variety of projects in cerebrovascular surgery. Collaborative research includes evaluation of safety and efficacy of xenon-CT for cerebral blood flow monitoring in subarachnoid hemorrhage and trauma; evaluation of a noninvasive near-infrared spectroscopy device for detection of intracerebral hematomas; evaluation of brain oxygen tension monitoring in subarachnoid hemorrhage; arterial spin-labelling MR in AVM shunt visualization; MRI evaluation of carotid plaques and hemispheric blood flow before and after carotid endarterectomy; cost-effectiveness analysis of imaging in carotid endarterectomy and cerebral aneurysm repair; clinical outcomes for surgical treatment of patients with intractable occipital neuralgia.

Description of Clinical Expertise

Cerebrovascular surgery: microsurgical repair of cerebral aneurysms, arteriovenous malformations, arteriovenous fistulas, carotid atherosclerosis/endarterectomy.

Peripheral nerve surgery: peripheral nerve tumors, entrapments (carpal tunnel syndrome, ulnar entrapment neuropathy, thoracic outlet syndrome, etc.), and injuries (including brachial plexus) requiring nerve repair, grafting or nerve transfers.

Microvascular decompression surgery for trigeminal neuralgia, hemifacial spasm, etc.

Cranial and spinal tumor resection: including pituitary adenomas, meningiomas, metastases, gliomas, hemangioblastomas, neurofibromas, schwannomas, craniopharyngiomas, etc.

Spinal surgery for degenerative disc disease, radiculopathy, myelopathy.

Selected Publications

Cullen DK, Huang JH, Zager EL, Browne K, Zhang J, Groff R, Smith DH: Long-term survival and integration of transplanted engineered nervous tissue constructs promotes peripheral nerve regeneration. Tissue Eng 15(7): 1677-85, Jul 2009.

Rohan R, Stiefel M, Udoetuk J, Spiotta A, Levine JM, Kofke WA, Zager E, Yang W, Leroux P: Brain oxygen tension and outcome in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 109(6): 1075-82, 2008.

Wolf RL, Wang J, Detre JA, Zager EL, Hurst RW: Arteriovenous shunt visualization in arteriovenous malformations with arterial spin-labeling MR. Am J Neuroradiol 29(4): 681-687, Apr 2008.

Ranalli NJ, Kline DG, McGarvey ML, Boulis NM, Zager EL: Clinical Problem-Solving: Brachial Plexus Closed Injury and Reconstruction. Neurosurgery 62(6): 1330-1339, Jun 2008.

Heuer GG, Stiefel MF, Nagpal S, Basil AK, Smith DS, Zager EL: Carotid endarterectomy under regional anesthesia: A primer for the uninitiated. Neurosurg Q 18(3): 201-206, Sep 2008.

Stein S, Burnett M, Riina H, Sonnad S, Zager EL: Completion angiography for surgically-treated cerebral aneurysms: An economic analysis. Neurosurgery 61(6): 1162-1169, Dec 2007.

Whitmore RG, Simon SL, Hurst RW, Nisenbaum HL, Kasner SE, Zager EL: Bow hunter’s syndrome caused by accessory cervical ossification: posterolateral decompression and the use of intraoperative Doppler ultrasonography. Surg Neurol 67(2): 169-171, Feb 2007.

Pfister BJ, Huang JH, Kameswaran N, Zager EL, Smith DH: Neural engineering to produce in vitro nerve constructs and neurointerface. Neurosurgery 60(1): 137-141, Jan 2007.

Magge SN, Chen HI, Zager EL: Dystrophic calcification and infraclavicular brachial plexopathy: case report. Neurosurgery 58: 1216, 2006.

Storm PB, Zager E, Magge S: Surgical clipping of a PICA aneurysm in a 6-month-old child. Pediatr Neurosurg 42: 406-8, 2006.

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Last updated: 10/29/2012
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