An area of interest is the function of a delta opioid receptor SNP, rs678849, in cocaine addiction and in therapeutic response of opioid addicted persons to buprenorphine and methadone.
Another area of interest is somatic DNA variation in CNS disorders, as a source of risk for those illnesses. We have projects in temporal lobe epilepsy, schizophrenia and cocaine addiction, using DNA from human brains of persons with these illnesses to map one type of somatic variation, long interspersed elements (LINE-1s).
A third area of interest is a double-blind, placebo-controlled phase II randomized clinical trial of a novel triple monoamine reuptake inhibitor in cocaine addiction.
Crist RC, Clarke TK, Ang A, Ambrose-Lanci LM, Lohoff FW, Saxon AJ, Ling W2, Hillhouse MP, Bruce RD, Woody G, Berrettini WH.: An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans. Neuropsychopharmacol 38: 2003-10, 2013.
Crist RC, Ambrose-Lanci LM, Vaswani M, Clarke TK, Zeng A, Yuan C, Ferraro TN, Hakonarson H, Kampman KM, Dackis CA, Pettinati HM, O'Brien CP, Oslin DW, Doyle GA, Lohoff FW, Berrettini WH: Case-control association analysis of polymorphisms in the delta-opioid receptor, OPRD1, with cocaine and opioid addicted populations. Drug Alcohol Depend 127: 122-8, 2013.
Doyle GA, Berrettini WH.: Somatic DNA Variation in Brain as a Source of Risk for CNS Diseases. Neuropsychopharmacology 41: 386-7, 2016.
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Last updated: 04/24/2017
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