Penn Medicine
Help | Search | Site Map | Contact   
faculty photo

John Q. Trojanowski, MD, PhD

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Director, National Institute of Neurological Disorders & Stroke Morris K. Udall Parkinson’s Disease Research Center of Excellence, University of Pennsylvania School of Medicine
Department: Pathology and Laboratory Medicine

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Lab: 215-662-3292
Graduate Group Affiliations
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
M.D.
Tufts University School of Medicine, 1976.
Post-Graduate Training
Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977.
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979.
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA , 1979-1980.
Certifications
American Board of Pathology, Anatomic Pathology and Neuropathology National Board of Medical Examiners - No. 138521 , 1981.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Description of Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Brennan Laura, Devlin Kathryn M, Xie Sharon X, Mechanic-Hamilton Dawn, Tran Baochan, Hurtig Howard H, Chen-Plotkin Alice, Chahine Lama M, Morley James F, Duda John E, Roalf David R, Dahodwala Nabila, Rick Jacqueline, Trojanowski John Q, Moberg Paul J, Weintraub Daniel: Neuropsychological Subgroups in Non-Demented Parkinson's Disease: A Latent Class Analysis. Journal of Parkinson's disease Apr 2017.

Covell Dustin J, Robinson John L, Akhtar Rizwan S, Grossman Murray, Weintraub Daniel, Bucklin Hannah M, Pitkin Rose M, Riddle Dawn, Yousef Ahmed, Trojanowski John Q, Lee Virginia M-Y: Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease. Neuropathology and applied neurobiology Apr 2017.

Gendron Tania F, Chew Jeannie, Stankowski Jeannette N, Hayes Lindsey R, Zhang Yong-Jie, Prudencio Mercedes, Carlomagno Yari, Daughrity Lillian M, Jansen-West Karen, Perkerson Emilie A, O'Raw Aliesha, Cook Casey, Pregent Luc, Belzil Veronique, van Blitterswijk Marka, Tabassian Lilia J, Lee Chris W, Yue Mei, Tong Jimei, Song Yuping, Castanedes-Casey Monica, Rousseau Linda, Phillips Virginia, Dickson Dennis W, Rademakers Rosa, Fryer John D, Rush Beth K, Pedraza Otto, Caputo Ana M, Desaro Pamela, Palmucci Carla, Robertson Amelia, Heckman Michael G, Diehl Nancy N, Wiggs Edythe, Tierney Michael, Braun Laura, Farren Jennifer, Lacomis David, Ladha Shafeeq, Fournier Christina N, McCluskey Leo F, Elman Lauren B, Toledo Jon B, McBride Jennifer D, Tiloca Cinzia, Morelli Claudia, Poletti Barbara, Solca Federica, Prelle Alessandro, Wuu Joanne, Jockel-Balsarotti Jennifer, Rigo Frank, Ambrose Christine, Datta Abhishek, Yang Weixing, Raitcheva Denitza, Antognetti Giovanna, McCampbell Alexander, Van Swieten John C, Miller Bruce L, Boxer Adam L, Brown Robert H, Bowser Robert, Miller Timothy M, Trojanowski John Q, Grossman Murray, Berry James D, Hu William T, Ratti Antonia, Traynor Bryan J, Disney Matthew D, Benatar Michael, Silani Vincenzo, Glass Jonathan D, Floeter Mary Kay, Rothstein Jeffrey D, Boylan Kevin B, Petrucelli Leonard: Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science translational medicine 9(383), Mar 2017.

Ono Maiko, Sahara Naruhiko, Kumata Katsushi, Ji Bin, Ni Ruiqing, Koga Shunsuke, Dickson Dennis W, Trojanowski John Q, Lee Virginia M-Y, Yoshida Mari, Hozumi Isao, Yoshiyama Yasumasa, van Swieten John C, Nordberg Agneta, Suhara Tetsuya, Zhang Ming-Rong, Higuchi Makoto: Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain : a journal of neurology 140(3): 764-780, Mar 2017.

Spinelli Edoardo G, Mandelli Maria Luisa, Miller Zachary A, Santos-Santos Miguel A, Wilson Stephen M, Agosta Federica, Grinberg Lea T, Huang Eric J, Trojanowski John Q, Meyer Marita, Henry Maya L, Comi Giancarlo, Rabinovici Gil, Rosen Howard J, Filippi Massimo, Miller Bruce L, Seeley William W, Gorno-Tempini Maria Luisa: Typical and atypical pathology in primary progressive aphasia variants. Annals of neurology 81(3): 430-443, Mar 2017.

Kovacs Gabor G, Robinson John L, Xie Sharon X, Lee Edward B, Grossman Murray, Wolk David A, Irwin David J, Weintraub Dan, Kim Christopher F, Schuck Theresa, Yousef Ahmed, Wagner Stephanie T, Suh Eunran, Van Deerlin Vivianna M, Lee Virginia M-Y, Trojanowski John Q: Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. Journal of neuropathology and experimental neurology Mar 2017.

Toledo Jon B, Arnold Matthias, Kastenmüller Gabi, Chang Rui, Baillie Rebecca A, Han Xianlin, Thambisetty Madhav, Tenenbaum Jessica D, Suhre Karsten, Thompson J Will, John-Williams Lisa St, MahmoudianDehkordi Siamak, Rotroff Daniel M, Jack John R, Motsinger-Reif Alison, Risacher Shannon L, Blach Colette, Lucas Joseph E, Massaro Tyler, Louie Gregory, Zhu Hongjie, Dallmann Guido, Klavins Kristaps, Koal Therese, Kim Sungeun, Nho Kwangsik, Shen Li, Casanova Ramon, Varma Sudhir, Legido-Quigley Cristina, Moseley M Arthur, Zhu Kuixi, Henrion Marc Y R, van der Lee Sven J, Harms Amy C, Demirkan Ayse, Hankemeier Thomas, van Duijn Cornelia M, Trojanowski John Q, Shaw Leslie M, Saykin Andrew J, Weiner Michael W, Doraiswamy P Murali, Kaddurah-Daouk Rima: Metabolic network failures in Alzheimer's disease-A biochemical road map. Alzheimer's & dementia : the journal of the Alzheimer's Association Mar 2017.

Weiner Michael W, Veitch Dallas P, Aisen Paul S, Beckett Laurel A, Cairns Nigel J, Green Robert C, Harvey Danielle, Jack Clifford R, Jagust William, Morris John C, Petersen Ronald C, Saykin Andrew J, Shaw Leslie M, Toga Arthur W, Trojanowski John Q: Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials. Alzheimer's & dementia : the journal of the Alzheimer's Association Mar 2017.

Deming Yuetiva, Li Zeran, Kapoor Manav, Harari Oscar, Del-Aguila Jorge L, Black Kathleen, Carrell David, Cai Yefei, Fernandez Maria Victoria, Budde John, Ma Shengmei, Saef Benjamin, Howells Bill, Huang Kuan-Lin, Bertelsen Sarah, Fagan Anne M, Holtzman David M, Morris John C, Kim Sungeun, Saykin Andrew J, De Jager Philip L, Albert Marilyn, Moghekar Abhay, O'Brien Richard, Riemenschneider Matthias, Petersen Ronald C, Blennow Kaj, Zetterberg Henrik, Minthon Lennart, Van Deerlin Vivianna M, Lee Virginia Man-Yee, Shaw Leslie M, Trojanowski John Q, Schellenberg Gerard, Haines Jonathan L, Mayeux Richard, Pericak-Vance Margaret A, Farrer Lindsay A, Peskind Elaine R, Li Ge, Di Narzo Antonio F, Kauwe John S K, Goate Alison M, Cruchaga Carlos: Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta neuropathologica Feb 2017.

Sposato Luciano A, Ruíz Vargas Estefanía, Riccio Patricia M, Toledo Jon B, Trojanowski John Q, Kukull Walter A, Cipriano Lauren E, Nucera Antonia, Whitehead Shawn N, Hachinski Vladimir: Milder Alzheimer's disease pathology in heart failure and atrial fibrillation. Alzheimer's & dementia : the journal of the Alzheimer's Association Feb 2017.

back to top
Last updated: 04/12/2017
The Trustees of the University of Pennsylvania
 
© The Trustees of the University of Pennsylvania. Site best viewed with Mozilla, NN, IE, or Safari.
SOM Home International Programs Penn Alumni Clinical Trials Centers and Institutes Departments Faculty Research Education Administration