Penn Medicine
Help | Search | Site Map | Contact   
faculty photo

John Q. Trojanowski, MD, PhD

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Director, National Institute of Neurological Disorders & Stroke Morris K. Udall Parkinson’s Disease Research Center of Excellence, University of Pennsylvania School of Medicine
Department: Pathology and Laboratory Medicine

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Lab: 215-662-3292
Graduate Group Affiliations
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
M.D.
Tufts University School of Medicine, 1976.
Post-Graduate Training
Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977.
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979.
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA , 1979-1980.
Certifications
American Board of Pathology, Anatomic Pathology and Neuropathology National Board of Medical Examiners - No. 138521 , 1981.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Description of Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Imamura Keiko, Sahara Naruhiko, Kanaan Nicholas M, Tsukita Kayoko, Kondo Takayuki, Kutoku Yumiko, Ohsawa Yutaka, Sunada Yoshihide, Kawakami Koichi, Hotta Akitsu, Yawata Satoshi, Watanabe Dai, Hasegawa Masato, Trojanowski John Q, Lee Virginia M-Y, Suhara Tetsuya, Higuchi Makoto, Inoue Haruhisa: Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. Scientific reports 6: 34904, Oct 2016.

Davis Marie Y, Johnson Catherine O, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Chen-Plotkin Alice, Van Deerlin Vivianna M, Quinn Joseph F, Chung Kathryn A, Peterson-Hiller Amie L, Rosenthal Liana S, Dawson Ted M, Albert Marilyn S, Goldman Jennifer G, Stebbins Glenn T, Bernard Bryan, Wszolek Zbigniew K, Ross Owen A, Dickson Dennis W, Eidelberg David, Mattis Paul J, Niethammer Martin, Yearout Dora, Hu Shu-Ching, Cholerton Brenna A, Smith Megan, Mata Ignacio F, Montine Thomas J, Edwards Karen L, Zabetian Cyrus P: Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease. JAMA neurology 73(10): 1217-1224, Oct 2016.

Brettschneider Johannes, Irwin David J, Boluda Susana, Byrne Matthew D, Fang Lubin, Lee Edward B, Robinson John L, Suh EunRan, Van Deerlin Vivianna M, Toledo Jon B, Grossman Murray, Hurtig Howard, Dengler Reinhard, Petri Susanne, Lee Virginia M-Y, Trojanowski John Q: Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type. Neuropathology and applied neurobiology Sep 2016.

Wisse L E M, Adler D H, Ittyerah R, Pluta J B, Robinson J L, Schuck T, Trojanowski J Q, Grossman M, Detre J A, Elliott M A, Toledo J B, Liu W, Pickup S, Das S R, Wolk D A, Yushkevich P A: Comparison of In Vivo and Ex Vivo MRI of the Human Hippocampal Formation in the Same Subjects. Cerebral cortex (New York, N.Y. : 1991) Sep 2016.

Kun-Rodrigues Celia, Ross Owen A, Orme Tatiana, Shepherd Claire, Parkkinen Laura, Darwent Lee, Hernandez Dena, Ansorge Olaf, Clark Lorraine N, Honig Lawrence S, Marder Karen, Lemstra Afina, Scheltens Philippe, van der Flier Wiesje, Louwersheimer Eva, Holstege Henne, Rogaeva Ekaterina, St George-Hyslop Peter, Londos Elisabet, Zetterberg Henrik, Barber Imelda, Braae Anne, Brown Kristelle, Morgan Kevin, Maetzler Walter, Berg Daniela, Troakes Claire, Al-Sarraj Safa, Lashley Tammaryn, Holton Janice, Compta Yaroslau, Van Deerlin Vivianna, Trojanowski John Q, Serrano Geidy E, Beach Thomas G, Clarimon Jordi, Lleó Alberto, Morenas-Rodríguez Estrella, Lesage Suzanne, Galasko Douglas, Masliah Eliezer, Santana Isabel, Diez Monica, Pastor Pau, Tienari Pentti J, Myllykangas Liisa, Oinas Minna, Revesz Tamas, Lees Andrew, Boeve Brad F, Petersen Ronald C, Ferman Tanis J, Escott-Price Valentina, Graff-Radford Neill, Cairns Nigel J, Morris John C, Stone David J, Pickering-Brown Stuart, Mann David, Dickson Dennis W, Halliday Glenda M, Singleton Andrew, Guerreiro Rita, Bras Jose: Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies. Neurobiology of aging Sep 2016.

Placek Katerina, Massimo Lauren, Olm Christopher, Ternes Kylie, Firn Kim, Van Deerlin Vivianna, Lee Edward B, Trojanowski John Q, Lee Virginia M-Y, Irwin David, Grossman Murray, McMillan Corey T: Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence. Neurology Sep 2016.

Spiller Krista J, Restrepo Clark R, Khan Tahiyana, Stieber Anna M, Kwong Linda K, Trojanowski John Q, Lee Virginia M-Y: Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice. Acta neuropathologica communications 4(1): 105, Sep 2016.

Makani Vishruti, Zhang Bin, Han Heeoon, Yao Yuemang, Lassalas Pierrik, Lou Kevin, Paterson Ian, Lee Virginia M Y, Trojanowski John Q, Ballatore Carlo, Smith Amos B, Brunden Kurt R: Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta neuropathologica communications 4(1): 106, Sep 2016.

James Bryan D, Wilson Robert S, Boyle Patricia A, Trojanowski John Q, Bennett David A, Schneider Julie A: TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia. Brain : a journal of neurology Sep 2016.

Mattsson Niklas, Zetterberg Henrik, Janelidze Shorena, Insel Philip S, Andreasson Ulf, Stomrud Erik, Palmqvist Sebastian, Baker David, Tan Hehir Cristina A, Jeromin Andreas, Hanlon David, Song Linan, Shaw Leslie M, Trojanowski John Q, Weiner Michael W, Hansson Oskar, Blennow Kaj: Plasma tau in Alzheimer disease. Neurology Sep 2016.

back to top
Last updated: 10/14/2016
The Trustees of the University of Pennsylvania
 
© The Trustees of the University of Pennsylvania. Site best viewed with Mozilla, NN, IE, or Safari.
SOM Home International Programs Penn Alumni Clinical Trials Centers and Institutes Departments Faculty Research Education Administration