Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.
Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.
Irwin David J, Grossman Murray, Weintraub Daniel, Hurtig Howard I, Duda John E, Xie Sharon X, Lee Edward B, Van Deerlin Vivianna M, Lopez Oscar L, Kofler Julia K, Nelson Peter T, Jicha Gregory A, Woltjer Randy, Quinn Joseph F, Kaye Jeffery, Leverenz James B, Tsuang Debby, Longfellow Katelan, Yearout Dora, Kukull Walter, Keene C Dirk, Montine Thomas J, Zabetian Cyrus P, Trojanowski John Q: Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. The Lancet. Neurology 16(1): 55-65, Jan 2017.
Brown Christopher A, Johnson Nathan F, Anderson-Mooney Amelia J, Jicha Gregory A, Shaw Leslie M, Trojanowski John Q, Van Eldik Linda J, Schmitt Frederick A, Smith Charles D, Gold Brian T: Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease. NeuroImage. Clinical 13: 106-115, 2017.
Brunden Kurt R, Lee Virginia M-Y, Smith Amos B, Trojanowski John Q, Ballatore Carlo: Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs. Neurobiology of disease Dec 2016.
Kovacs Gabor G, Kwong Linda K, Grossman Murray, Irwin David J, Lee Edward B, Robinson John L, Suh Eunran, Van Deerlin Vivianna M, Lee Virginia M, Trojanowski John Q: Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland) Dec 2016.
McMillan Corey T, Irwin David J, Nasrallah Ilya, Phillips Jeffrey S, Spindler Meredith, Rascovsky Katya, Ternes Kylie, Jester Charles, Wolk David A, Kwong Linda K, Lee Virginia M-Y, Lee Edward B, Trojanowski John Q, Grossman Murray: Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. Acta neuropathologica 132(6): 935-937, Dec 2016.
Weiner Michael W, Veitch Dallas P, Aisen Paul S, Beckett Laurel A, Cairns Nigel J, Green Robert C, Harvey Danielle, Jack Clifford R, Jagust William, Morris John C, Petersen Ronald C, Salazar Jennifer, Saykin Andrew J, Shaw Leslie M, Toga Arthur W, Trojanowski John Q: The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement. Alzheimer's & dementia : the journal of the Alzheimer's Association Dec 2016.
Chapuis Julien, Flaig Amandine, Grenier-Boley Benjamin, Eysert Fanny, Pottiez Virginie, Deloison Gaspard, Vandeputte Alexandre, Ayral Anne-Marie, Mendes Tiago, Desai Shruti, Goate Alison M, Kauwe John S K, Leroux Florence, Herledan Adrien, Demiautte Florie, Bauer Charlotte, Checler Fréderic, Petersen Ronald C, Blennow Kaj, Zetterberg Henrik, Minthon Lennart, Van Deerlin Vivianna M, Lee Virginia Man-Yee, Shaw Leslie M, Trojanowski John Q, Albert Marilyn, Moghekar Abhay, O'Brien Richard, Peskind Elaine R, Malmanche Nicolas, Schellenberg Gerard D, Dourlen Pierre, Song Ok-Ryul, Cruchaga Carlos, Amouyel Philippe, Deprez Benoit, Brodin Priscille, Lambert Jean-Charles: Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta neuropathologica Dec 2016.
Dong Aoyan, Toledo Jon B, Honnorat Nicolas, Doshi Jimit, Varol Erdem, Sotiras Aristeidis, Wolk David, Trojanowski John Q, Davatzikos Christos: Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers. Brain : a journal of neurology Dec 2016.
Guo Jing L, Narasimhan Sneha, Changolkar Lakshmi, He Zhuohao, Stieber Anna, Zhang Bin, Gathagan Ronald J, Iba Michiyo, McBride Jennifer D, Trojanowski John Q, Lee Virginia M Y: Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. The Journal of experimental medicine 213(12): 2635-2654, Nov 2016.
Khanna Mansi R, Kovalevich Jane, Lee Virginia M-Y, Trojanowski John Q, Brunden Kurt R: Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimer's & dementia : the journal of the Alzheimer's Association 12(10): 1051-1065, Oct 2016.
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Last updated: 01/12/2017
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