Penn Comprehensive Neuroscience Center

Faculty Members
faculty photo

John Q. Trojanowski, MD, PhD

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Director, National Institute of Neurological Disorders & Stroke Morris K. Udall Parkinson’s Disease Research Center of Excellence, University of Pennsylvania School of Medicine
Department: Pathology and Laboratory Medicine

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Lab: 215-662-3292
Graduate Group Affiliations
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
M.D.
Tufts University School of Medicine, 1976.
Post-Graduate Training
Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977.
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979.
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA , 1979-1980.
Certifications
American Board of Pathology, Anatomic Pathology and Neuropathology National Board of Medical Examiners - No. 138521 , 1981.
Permanent link
 
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Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Description of Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Kang Ju-Hee, Mollenhauer Brit, Coffey Christopher S, Toledo Jon B, Weintraub Daniel, Galasko Douglas R, Irwin David J, Van Deerlin Vivianna, Chen-Plotkin Alice S, Caspell-Garcia Chelsea, Waligórska Teresa, Taylor Peggy, Shah Nirali, Pan Sarah, Zero Pawel, Frasier Mark, Marek Kenneth, Kieburtz Karl, Jennings Danna, Tanner Caroline M, Simuni Tanya, Singleton Andrew, Toga Arthur W, Chowdhury Sohini, Trojanowski John Q, Shaw Leslie M: CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study. Acta neuropathologica Mar 2016.

Toledo Jon B, Gopal Pallavi, Raible Kevin, Irwin David J, Brettschneider Johannes, Sedor Samantha, Waits Kayla, Boluda Susana, Grossman Murray, Van Deerlin Vivianna M, Lee Edward B, Arnold Steven E, Duda John E, Hurtig Howard, Lee Virginia M-Y, Adler Charles H, Beach Thomas G, Trojanowski John Q: Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta neuropathologica 131(3): 393-409, Mar 2016.

Kovalevich Jane, Cornec Anne-Sophie, Yao Yuemang, James Michael, Crowe Alexander, Lee Virginia M-Y, Trojanowski John Q, Smith Amos B, Ballatore Carlo, Brunden Kurt R: Characterization of brain-penetrant pyrimidine-containing molecules with differential microtubule-stabilizing activities developed as potential therapeutic agents for Alzheimer's disease and related tauopathies. The Journal of pharmacology and experimental therapeutics Mar 2016.

Brennan Laura, Siderowf Andrew, Rubright Jonathan D, Rick Jacqueline, Dahodwala Nabila, Duda John E, Hurtig Howard, Stern Matthew, Xie Sharon X, Rennert Lior, Karlawish Jason, Shea Judy A, Trojanowski John Q, Weintraub Daniel: The Penn Parkinson's Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson's disease. Parkinsonism & related disorders Feb 2016.

Montine Thomas J, Monsell Sarah E, Beach Thomas G, Bigio Eileen H, Bu Yunqi, Cairns Nigel J, Frosch Matthew, Henriksen Jonathan, Kofler Julia, Kukull Walter A, Lee Edward B, Nelson Peter T, Schantz Aimee M, Schneider Julie A, Sonnen Joshua A, Trojanowski John Q, Vinters Harry V, Zhou Xiao-Hua, Hyman Bradley T: Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association 12(2): 164-9, Feb 2016.

Irwin David J, Brettschneider Johannes, McMillan Corey T, Cooper Felicia, Olm Christopher, Arnold Steven E, Van Deerlin Vivianna M, Seeley William W, Miller Bruce L, Lee Edward B, Lee Virginia M-Y, Grossman Murray, Trojanowski John Q: Deep clinical and neuropathological phenotyping of Pick disease. Annals of neurology 79(2): 272-87, Feb 2016.

Kovacs Gabor G, Ferrer Isidro, Grinberg Lea T, Alafuzoff Irina, Attems Johannes, Budka Herbert, Cairns Nigel J, Crary John F, Duyckaerts Charles, Ghetti Bernardino, Halliday Glenda M, Ironside James W, Love Seth, Mackenzie Ian R, Munoz David G, Murray Melissa E, Nelson Peter T, Takahashi Hitoshi, Trojanowski John Q, Ansorge Olaf, Arzberger Thomas, Baborie Atik, Beach Thomas G, Bieniek Kevin F, Bigio Eileen H, Bodi Istvan, Dugger Brittany N, Feany Mel, Gelpi Ellen, Gentleman Stephen M, Giaccone Giorgio, Hatanpaa Kimmo J, Heale Richard, Hof Patrick R, Hofer Monika, Hortobágyi Tibor, Jellinger Kurt, Jicha Gregory A, Ince Paul, Kofler Julia, Kövari Enikö, Kril Jillian J, Mann David M, Matej Radoslav, McKee Ann C, McLean Catriona, Milenkovic Ivan, Montine Thomas J, Murayama Shigeo, Lee Edward B, Rahimi Jasmin, Rodriguez Roberta D, Rozemüller Annemieke, Schneider Julie A, Schultz Christian, Seeley William, Seilhean Danielle, Smith Colin, Tagliavini Fabrizio, Takao Masaki, Thal Dietmar Rudolf, Toledo Jon B, Tolnay Markus, Troncoso Juan C, Vinters Harry V, Weis Serge, Wharton Stephen B, White Charles L, Wisniewski Thomas, Woulfe John M, Yamada Masahito, Dickson Dennis W: Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta neuropathologica 131(1): 87-102, Jan 2016.

Mata Ignacio F, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Chen-Plotkin Alice, Van Deerlin Vivianna M, Ritz Beate, Rausch Rebecca, Factor Stewart A, Wood-Siverio Cathy, Quinn Joseph F, Chung Kathryn A, Peterson-Hiller Amie L, Goldman Jennifer G, Stebbins Glenn T, Bernard Bryan, Espay Alberto J, Revilla Fredy J, Devoto Johnna, Rosenthal Liana S, Dawson Ted M, Albert Marilyn S, Tsuang Debby, Huston Haley, Yearout Dora, Hu Shu-Ching, Cholerton Brenna A, Montine Thomas J, Edwards Karen L, Zabetian Cyrus P: GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 31(1): 95-102, Jan 2016.

Zetterberg Henrik, Skillbäck Tobias, Mattsson Niklas, Trojanowski John Q, Portelius Erik, Shaw Leslie M, Weiner Michael W, Blennow Kaj: Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression. JAMA neurology 73(1): 60-7, Jan 2016.

Irwin David J, Byrne Matthew D, McMillan Corey T, Cooper Felicia, Arnold Steven E, Lee Edward B, Van Deerlin Vivianna M, Xie Sharon X, Lee Virginia M-Y, Grossman Murray, Trojanowski John Q: Semi-Automated Digital Image Analysis of Pick's Disease and TDP-43 Proteinopathy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 64(1): 54-66, Jan 2016.

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Last updated: 03/30/2016
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