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Geoffrey Karl Aguirre, MD, PhD
Assistant Professor of Neurology
Associate Director, Penn Center for Neuroscience and Society
Director, Computing Core, Neuroscience Neuroimaging Center (NNC) NINDS P30 Institutional Center
Department: Neurology
Contact information
Department of Neurology
3400 Spruce Street
Philadelphia, PA 19104
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3390
Fax: 215-349-8260
Fax: 215-349-8260
Email:
aguirreg@mail.med.upenn.edu
aguirreg@mail.med.upenn.edu
Graduate Group Affiliations
Publications
Education:
BA (Politics)
Princeton University, 1992.
PhD (Neuroscience)
University of Pennsylvania, 2000.
MD
University of Pennsylvania, 2001.
BA (Politics)
Princeton University, 1992.
PhD (Neuroscience)
University of Pennsylvania, 2000.
MD
University of Pennsylvania, 2001.
Post-Graduate Training
Internship in Medicine, Pennsylvania Hospital, 2001-2002.
Resident in Neurology, University of Pennsylvania, 2002-2004.
Internship in Medicine, Pennsylvania Hospital, 2001-2002.
Resident in Neurology, University of Pennsylvania, 2002-2004.
Certifications
American Board of Neurology, 2005.
Permanent linkAmerican Board of Neurology, 2005.
Description of Research Expertise
I study human cortical organization for vision, and how this organization is altered by neurologic and ophthalmologic disease. Human visual cortex is composed of early, “retinotopically” organized visual areas, as well as more specialized, “categorical” areas that process specific visual features (such as facial appearance). My work has varied along two dimensions within this research space: scale and perturbation. I have examined the organization of visual cortex from its large-scale, anatomical arrangement to the precise and subtle form of population neural coding for object features. These studies at different scales of cortical organization have further been conducted both in healthy controls as well as in patients for whom visual function has been perturbed by retinal disease or cerebral dysfunction. I make use of a variety of scientific techniques, although the majority of my research uses BOLD fMRI, which is a non-invasive measure of neural activity in human participants.Description of Clinical Expertise
My sub-speciality in Behavioral Neurology, and I treat patients with a variety of disturbances of visual perception, thinking and memory.Selected Publications
Kahn David Alexander, Aguirre Geoffrey Karl: Confounding of norm-based and adaptation effects in brain responses. NeuroImage 60(4): 2294-9, May 2012.Datta Ritobrato, Detre John A, Aguirre Geoffrey K, Cucchiara Brett: Absence of changes in cortical thickness in patients with migraine. Cephalalgia : an international journal of headache 31(14): 1452-8, Oct 2011.
Aleman Tomas S, Cideciyan Artur V, Aguirre Geoffrey K, Huang Wei Chieh, Mullins Cristina L, Roman Alejandro J, Sumaroka Alexander, Olivares Melani B, Tsai Frank F, Schwartz Sharon B, Vandenberghe Luk H, Limberis Maria P, Stone Edwin M, Bell Peter, Wilson James M, Jacobson Samuel G: Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model. Investigative ophthalmology & visual science 52(9): 6898-910, Aug 2011.
Aguirre Geoffrey Karl, Mattar Marcelo Gomes, Magis-Weinberg Lucía: de Bruijn cycles for neural decoding. NeuroImage 56(3): 1293-300, Jun 2011.
Morgan Lindsay K, Macevoy Sean P, Aguirre Geoffrey K, Epstein Russell A: Distances between real-world locations are represented in the human hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 31(4): 1238-45, Jan 2011.
Harris Alison, Aguirre Geoffrey Karl: Neural tuning for face wholes and parts in human fusiform gyrus revealed by FMRI adaptation. Journal of neurophysiology 104(1): 336-45, Jul 2010.
Wencil Elaine B, Coslett H Branch, Aguirre Geoffrey K, Chatterjee Anjan: Carving the clock at its component joints: neural bases for interval timing. Journal of neurophysiology 104(1): 160-8, Jul 2010.
Kahn David Alexander, Harris Alison M, Wolk David A, Aguirre Geoffrey Karl: Temporally distinct neural coding of perceptual similarity and prototype bias. Journal of vision 10(10): 12, 2010.
Drucker Daniel M, Aguirre Geoffrey K: Different spatial scales of shape similarity representation in lateral and ventral LOC. Cerebral cortex (New York, N.Y. : 1991) 19(10): 2269-80, Oct 2009.
Drucker Daniel M, Kerr Wesley Thomas, Aguirre Geoffrey Karl: Distinguishing conjoint and independent neural tuning for stimulus features with fMRI adaptation. Journal of neurophysiology 101(6): 3310-24, Jun 2009.

