Dr. Cullen is a Research Assistant Professor of Neurosurgery at the Perelman School of Medicine, University of Pennsylvania. Dr. Cullen’s research program operates at the intersection of Neurotrauma and Neural Engineering (http://www.med.upenn.edu/cullenlab/). In the realm of Neurotrauma, the objective is to apply engineering principles to increase our understanding of the causative mechanisms and pathophysiological responses following traumatic injury to the nervous system. Specific attention is given to neural injury biomechanics and mechanisms of acute biophysical cellular/tissue damage. In the arena of Neural Engineering, the objective is to develop neurotechnology to mitigate trauma-induced deficits or augment the body’s capacity for regeneration. Here focus is given to neural tissue engineering strategies and the development of biohybrid neurobiological-electrical interface technology.
Dr. Cullen is currently an active member of the Biomedical Engineering Society, the American Society of Mechanical Engineers, the National Neurotrauma Society, and the Society for Neuroscience. Dr. Cullen also serves on the editorial board of Critical Reviews in Biomedical Engineering.
Cullen Lab Research Thrusts:
Regenerative Medicine & Neural Tissue Engineering – living scaffolds for neuroregeneration; micro-tissue engineering to restore brain circuitry; biological neuromodulation; “biohybrid” neuroprosthetic interfaces; cell function in 3-D microenvironments; in vitro neural interface microsystems.
Traumatic Brain Injury (TBI) & Neurodegeneration – biomechanics; cell/tissue injury tolerance criteria; blast injury; traumatic proteinopathies; mechanisms of neurophysiological dysfunction; wireless neuromonitoring technology;
Winter, C. C., Katiyar, K. S. (co-first author), Hernandez, N. S., Song, Y. J., Struzyna, L. A., Harris, J. P., Cullen, D. K.: Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration. Acta Biomaterialia 38: 44-58, 2016.
Harris, J. P., Struzyna, L. A., Murphy, P. L., Adewole, O. I., Kuo, E., Cullen, D. K.: Advanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain. J Neural Engineering 13(1): 016019, 2016.
Katiyar, K. S., Winter, C. C., Struzyna, L. A., Harris, J. P., Cullen, D. K.
: Mechanical elongation of astrocyte processes to create living scaffolds for nervous system regeneration. Tissue Engin & Regen Med June 7, 2016 Notes: [Epub Ahead of Print] Doi.10.1002/term.2168.
Struzyna, L. A., Wolf, J. A., Mietus, C. J., Chen, H. I., Smith, D. H., Cullen, D. K.: Rebuilding brain circuitry with living micro-tissue engineered neural networks. Tissue Engineering (Part A) 21(21-22): 2744-56, 2015.
Struzyna, L. A., Harris, J. P., Katiyar, K. S., Chen, H. I., Cullen, D. K.: Restoring nervous system structure and function using tissue engineered living scaffolds Neural Regeneration Research 10(5): 679-85, 2015.
Struzyna, L. A., Katiyar, K. S., Cullen, D. K.: Living scaffolds for neuroregeneration. Current Opinion in Solid State & Material Science 18(6): 308-18, 2014 Notes: cover article.
Cullen, D. K., Smith D. H.: Bionic connections: living bridges to connect bionic limbs to the nervous system. Scientific American 308(1): 52-7, 2013.
Cullen, D. K., Tang-Schomer, M. D., Struzyna, L. A., Patel, A. R., Johnson, V. E., Wolf, J. A., Smith, D. H.: Micro-tissue engineered constructs with living axons for targeted tract reconstruction. Tissue Engineering (Part A) 18(21-22): 2280-89, 2012.
Cullen, D. K., Wolf, J. A., Vernekar, V. N., Vukasinovic, J., LaPlaca, M. C.: Neural tissue engineering and biohybridized microsystems for neurobiological investigation in vitro (part 1). Critical Reviews in Biomedical Engineering 39(3): 201-240, 2011.
Cullen, D. K., Wolf, J. A., Smith, D. H., Pfister, B. J.: Neural tissue engineering for neuroregeneration and biohybridized interface microsystems in vivo (part 2). Critical Reviews in Biomedical Engineering 39(3): 241-259, 2011.
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Last updated: 01/11/2017
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