Penn Comprehensive Neuroscience Center

Faculty Members
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Gerard D Schellenberg, Ph.D.

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology and Laboratory Medicine
University of Pennsylvania School of Medicine
Room 609B, Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104
Graduate Group Affiliations
Education:
B.S. (Biochemistry/minor: Cell Biology)
University of California at Riverside, Riverside, California, 1973.
Ph.D. (Biochemistry/minor- Cell Biology)
University of California at Riverside, Riverside, California, 1978.
Post-Graduate Training
Senior Research Fellow, Department of Medical Genetics, School of Medicine, RG-20, University of Washington, 1978-1979.
Senior Research Fellow, Division of Neurology, Department of Medicine, University of Washington, 1979-1982.
NIH Post Doctoratal Fellowship, National Institute of Health, 1980-1982.
Senior Research Fellow, Department of Genetics, School of Medicine, University of Washington, 1982-1983.
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Selected Publications

Naj Adam C, Jun Gyungah, Reitz Christiane, Kunkle Brian W, Perry William, Park Yo Son, Beecham Gary W, Rajbhandary Ruchita A, Hamilton-Nelson Kara L, Wang Li-San, Kauwe John S K, Huentelman Matthew J, Myers Amanda J, Bird Thomas D, Boeve Bradley F, Baldwin Clinton T, Jarvik Gail P, Crane Paul K, Rogaeva Ekaterina, Barmada M Michael, Demirci F Yesim, Cruchaga Carlos, Kramer Patricia L, Ertekin-Taner Nilufer, Hardy John, Graff-Radford Neill R, Green Robert C, Larson Eric B, St George-Hyslop Peter H, Buxbaum Joseph D, Evans Denis A, Schneider Julie A, Lunetta Kathryn L, Kamboh M Ilyas, Saykin Andrew J, Reiman Eric M, De Jager Philip L, Bennett David A, Morris John C, Montine Thomas J, Goate Alison M, Blacker Deborah, Tsuang Debby W, Hakonarson Hakon, Kukull Walter A, Foroud Tatiana M, Martin Eden R, Haines Jonathan L, Mayeux Richard P, Farrer Lindsay A, Schellenberg Gerard D, Pericak-Vance Margaret A: Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study. JAMA neurology Sep 2014.

Jun Gyungah, Asai Hirohide, Zeldich Ella, Drapeau Elodie, Chen CiDi, Chung Jaeyoon, Park Jong-Ho, Kim Sehwa, Haroutunian Vahram, Foroud Tatiana, Kuwano Ryozo, Haines Jonathan L, Pericak-Vance Margaret A, Schellenberg Gerard D, Lunetta Kathryn L, Kim Jong-Won, Buxbaum Joseph D, Mayeux Richard, Ikezu Tsuneya, Abraham Carmela R, Farrer Lindsay A: PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Annals of neurology 76(3): 379-92, Sep 2014.

Samocha Kaitlin E, Robinson Elise B, Sanders Stephan J, Stevens Christine, Sabo Aniko, McGrath Lauren M, Kosmicki Jack A, Rehnström Karola, Mallick Swapan, Kirby Andrew, Wall Dennis P, MacArthur Daniel G, Gabriel Stacey B, DePristo Mark, Purcell Shaun M, Palotie Aarno, Boerwinkle Eric, Buxbaum Joseph D, Cook Edwin H, Gibbs Richard A, Schellenberg Gerard D, Sutcliffe James S, Devlin Bernie, Roeder Kathryn, Neale Benjamin M, Daly Mark J: A framework for the interpretation of de novo mutation in human disease. Nature genetics 46(9): 944-50, Sep 2014.

Beecham Gary W, Hamilton Kara, Naj Adam C, Martin Eden R, Huentelman Matt, Myers Amanda J, Corneveaux Jason J, Hardy John, Vonsattel Jean-Paul, Younkin Steven G, Bennett David A, De Jager Philip L, Larson Eric B, Crane Paul K, Kamboh M Ilyas, Kofler Julia K, Mash Deborah C, Duque Linda, Gilbert John R, Gwirtsman Harry, Buxbaum Joseph D, Kramer Patricia, Dickson Dennis W, Farrer Lindsay A, Frosch Matthew P, Ghetti Bernardino, Haines Jonathan L, Hyman Bradley T, Kukull Walter A, Mayeux Richard P, Pericak-Vance Margaret A, Schneider Julie A, Trojanowski John Q, Reiman Eric M, Schellenberg Gerard D, Montine Thomas J: Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias. PLoS genetics 10(9): e1004606, Sep 2014.

Toledo Jon B, Van Deerlin Vivianna M, Lee Edward B, Suh EunRan, Baek Young, Robinson John L, Xie Sharon X, McBride Jennifer, Wood Elisabeth M, Schuck Theresa, Irwin David J, Gross Rachel G, Hurtig Howard, McCluskey Leo, Elman Lauren, Karlawish Jason, Schellenberg Gerard, Chen-Plotkin Alice, Wolk David, Grossman Murray, Arnold Steven E, Shaw Leslie M, Lee Virginia M-Y, Trojanowski John Q: A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. Alzheimer's & dementia : the journal of the Alzheimer's Association 10(4): 477-84.e1, Jul 2014.

Benitez Bruno A, Jin Sheng Chih, Guerreiro Rita, Graham Rob, Lord Jenny, Harold Denise, Sims Rebecca, Lambert Jean-Charles, Gibbs J Raphael, Bras Jose, Sassi Celeste, Harari Oscar, Bertelsen Sarah, Lupton Michelle K, Powell John, Bellenguez Celine, Brown Kristelle, Medway Christopher, Haddick Patrick C G, van der Brug Marcel P, Bhangale Tushar, Ortmann Ward, Behrens Tim, Mayeux Richard, Pericak-Vance Margaret A, Farrer Lindsay A, Schellenberg Gerard D, Haines Jonathan L, Turton Jim, Braae Anne, Barber Imelda, Fagan Anne M, Holtzman David M, Morris John C, Williams Julie, Kauwe John S K, Amouyel Philippe, Morgan Kevin, Singleton Andy, Hardy John, Goate Alison M, Cruchaga Carlos: Missense variant in TREML2 protects against Alzheimer's disease. Neurobiology of aging 35(6): 1510.e19-26, Jun 2014.

Nelson Peter T, Estus Steven, Abner Erin L, Parikh Ishita, Malik Manasi, Neltner Janna H, Ighodaro Eseosa, Wang Wang-Xia, Wilfred Bernard R, Wang Li-San, Kukull Walter A, Nandakumar Kannabiran, Farman Mark L, Poon Wayne W, Corrada Maria M, Kawas Claudia H, Cribbs David H, Bennett David A, Schneider Julie A, Larson Eric B, Crane Paul K, Valladares Otto, Schmitt Frederick A, Kryscio Richard J, Jicha Gregory A, Smith Charles D, Scheff Stephen W, Sonnen Joshua A, Haines Jonathan L, Pericak-Vance Margaret A, Mayeux Richard, Farrer Lindsay A, Van Eldik Linda J, Horbinski Craig, Green Robert C, Gearing Marla, Poon Leonard W, Kramer Patricia L, Woltjer Randall L, Montine Thomas J, Partch Amanda B, Rajic Alexander J, Richmire KatieRose, Monsell Sarah E, Schellenberg Gerard D, Fardo David W: ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta neuropathologica 127(6): 825-43, Jun 2014.

McMillan Corey T, Toledo Jon B, Avants Brian B, Cook Philip A, Wood Elisabeth M, Suh Eunran, Irwin David J, Powers John, Olm Christopher, Elman Lauren, McCluskey Leo, Schellenberg Gerard D, Lee Virginia M-Y, Trojanowski John Q, Van Deerlin Vivianna M, Grossman Murray: Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration. Neurobiology of aging 35(6): 1473-82, Jun 2014.

Pinto Dalila, Delaby Elsa, Merico Daniele, Barbosa Mafalda, Merikangas Alison, Klei Lambertus, Thiruvahindrapuram Bhooma, Xu Xiao, Ziman Robert, Wang Zhuozhi, Vorstman Jacob A S, Thompson Ann, Regan Regina, Pilorge Marion, Pellecchia Giovanna, Pagnamenta Alistair T, Oliveira Bárbara, Marshall Christian R, Magalhaes Tiago R, Lowe Jennifer K, Howe Jennifer L, Griswold Anthony J, Gilbert John, Duketis Eftichia, Dombroski Beth A, De Jonge Maretha V, Cuccaro Michael, Crawford Emily L, Correia Catarina T, Conroy Judith, Conceição Inês C, Chiocchetti Andreas G, Casey Jillian P, Cai Guiqing, Cabrol Christelle, Bolshakova Nadia, Bacchelli Elena, Anney Richard, Gallinger Steven, Cotterchio Michelle, Casey Graham, Zwaigenbaum Lonnie, Wittemeyer Kerstin, Wing Kirsty, Wallace Simon, van Engeland Herman, Tryfon Ana, Thomson Susanne, Soorya Latha, Rogé Bernadette, Roberts Wendy, Poustka Fritz, Mouga Susana, Minshew Nancy, McInnes L Alison, McGrew Susan G, Lord Catherine, Leboyer Marion, Le Couteur Ann S, Kolevzon Alexander, Jiménez González Patricia, Jacob Suma, Holt Richard, Guter Stephen, Green Jonathan, Green Andrew, Gillberg Christopher, Fernandez Bridget A, Duque Frederico, Delorme Richard, Dawson Geraldine, Chaste Pauline, Café Cátia, Brennan Sean, Bourgeron Thomas, Bolton Patrick F, Bölte Sven, Bernier Raphael, Baird Gillian, Bailey Anthony J, Anagnostou Evdokia, Almeida Joana, Wijsman Ellen M, Vieland Veronica J, Vicente Astrid M, Schellenberg Gerard D, Pericak-Vance Margaret, Paterson Andrew D, Parr Jeremy R, Oliveira Guiomar, Nurnberger John I, Monaco Anthony P, Maestrini Elena, Klauck Sabine M, Hakonarson Hakon, Haines Jonathan L, Geschwind Daniel H, Freitag Christine M, Folstein Susan E, Ennis Sean, Coon Hilary, Battaglia Agatino, Szatmari Peter, Sutcliffe James S, Hallmayer Joachim, Gill Michael, Cook Edwin H, Buxbaum Joseph D, Devlin Bernie, Gallagher Louise, Betancur Catalina, Scherer Stephen W: Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. American journal of human genetics 94(5): 677-94, May 2014.

Dysken Maurice W, Sano Mary, Asthana Sanjay, Vertrees Julia E, Pallaki Muralidhar, Llorente Maria, Love Susan, Schellenberg Gerard D, McCarten J Riley, Malphurs Julie, Prieto Susana, Chen Peijun, Loreck David J, Trapp George, Bakshi Rajbir S, Mintzer Jacobo E, Heidebrink Judith L, Vidal-Cardona Ana, Arroyo Lillian M, Cruz Angel R, Zachariah Sally, Kowall Neil W, Chopra Mohit P, Craft Suzanne, Thielke Stephen, Turvey Carolyn L, Woodman Catherine, Monnell Kimberly A, Gordon Kimberly, Tomaska Julie, Segal Yoav, Peduzzi Peter N, Guarino Peter D: Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA 311(1): 33-44, Jan 2014.

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Last updated: 05/04/2011
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