Michael Ostap, Ph.D.
Professor of Physiology
Department: Physiology
Graduate Group Affiliations
Contact information
Pennsylvania Muscle Institute &
Department of Physiology
700A Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
Department of Physiology
700A Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
Office: (215) 573-9758
Lab: (215) 898-3685
Lab: (215) 898-3685
Email:
ostap@mail.med.upenn.edu
ostap@mail.med.upenn.edu
Publications
Education:
B.S. (Chemistry)
Illinois State University, 1988.
Ph.D. (Biochemistry, Molecular Biology, and Biophysics)
University of Minnesota, 1993.
Permanent linkB.S. (Chemistry)
Illinois State University, 1988.
Ph.D. (Biochemistry, Molecular Biology, and Biophysics)
University of Minnesota, 1993.
Description of Research Expertise
Research InterestsMolecular mechanisms of cell motility
Key words: Cell motility, myosin, actin, biochemistry, biophysics, single molecule, spectroscopy, microscopy, fluorescence, nanotechnology.
Description of Research
The goal of our research is to understand the molecular mechanisms of cell motility, which include: cell migration, regulation of cell shape and extracellular attachment, and intracellular transport. Cell motility is crucial for several normal and pathological processes, including: cell and tissue development, endocytosis, wound healing, immune response, and metastases of tumors.
Lab Personnel
Betsy Buechler, CAMB Student
Elizabeth Feeser, Post-doctoral
Michael Greenberg, Post-doctoral
Tianming Lin, Research Specialist
Serapion Pyrpassopoulos, Post-doctoral
Abbey Weith, Post-doctoral
Allison Zajac, CAMB Student
Selected Publications
M.J. Greenberg, E.M. Ostap: Regulation and control of myosin-I by the motor and light chain-binding domains. Trends Cell Biol 23(2): 81-89, Feb 2013.M. Greenberg, T. Lin, Y.E. Goldman, H. Shuman, E.M. Ostap: Myosin-Ic generates power over a range of loads via a new tension sensing mechanism. PNAS 109(37): E2433-40, August 2012.
S. Pyrpassopoulos, E.A. Feeser, J.N. Mazerik, M.J. Tyska, E.M. Ostap: Membrane-Bound Myo1c Powers Asymmetric Motility of Actin Filaments. Current Biology 22(18): 1688-92, August 2012.
C. Chen, M.J. Greenberg, J.M. Laakso, E.M. Ostap, Y.E. Goldman, H. Shuman: Kinetic schemes for post-synchronized single molecule dynamics. Biophysical Journal 102(6): L23-L25, March 2012.
Y.E. Goldman and E.M. Ostap: Introduction to Volume 4: Molecular Motors and Motility. Molecular Motors and Motility, Comprehensive Biophysics. Chapter 4: Y.E. Goldman, E.M. Ostap Overall: E.H. Egelman (eds.). 2012.
Y.E. Goldman and E.M. Ostap (volume editors): Volume 4: Molecular Motors and Motility. Comprehensive Biophysics. E.H. Egelman (series editor) (eds.). Elsevier, Page: 1-446, 2012 Notes: Volume containing 22 chapters from the leaders in the field of molecular motors.
J.H. Lewis, M.J. Greenberg, J.M. Laakso, H. Shuman, E.M. Ostap: Calcium regulation of myosin-I tension sensing. Biophysical Journal 102(12): 2799-807, 2012.
J. McKenna, Y.E. Goldman, E.M. Ostap: Sites of Glucose Transporter-4 Vesicle Fusion with the Plasma Membrane Correlate Spatially with Microtubules. PloS One 7(8): e43662, 2012.
Y.E. Goldman and E.M. Ostap: Myosin Motors: Kinetics of Myosin. Molecular Motors and Motility, Comprehensive Biophysics. Volume 4: Y.E. Goldman and E.M. Ostap Overall: E.H. Egelman (eds.). Elsevier, 2012.
T. Lin, M.J. Greenberg, J.R. Moore, and E.M. Ostap: A Hearing-Loss Associated Myo1c Mutation (R156W) Decreases the Myosin Duty Ratio and Force Sensitivity. Biochemistry In Press, Feb 2011.