Tatyana M. Svitkina, Ph.D.

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Contact information
221 Leidy Laboratories
Department of Biology
University of Pennsylvania
415 University Avenue
Philadelphia, PA 19104
Office: (215) 898-5736
Graduate Group Affiliations
Education:
BS/MS
Moscow State University, 1973.
Ph.D.
Cancer Research Center, Moscow, Russia, 1979.
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Description of Research Expertise

Research Interests: Roles of the actin cytoskeleton in cell motility

Keywords: Actin cytoskeleton, electron microscopy, cell motility, lamellipodia, filopodia

Research Details: We employ correlative light and electron microscopy of cultured cells to understand the molecular and structural organization of the actin cytoskeleton driving different forms of cell motility, such as protrusion of lamellipodia and filopodia at the leading edge of migrating cells, formation of intercellular junctions and synapses, assembly of contractile actin-myosin bundles, and membrane trafficking.

Lab Personnel: Changsong Yang, Ph.D.; Farida Korobova, Ph.D.; Agnieszka Galinska-Rakoczy, Ph.D.; Roman Gorelik, graduate student; Matthew Hoelzle, graduate student.

Selected Publications

Korobova Farida, Svitkina Tatyana: Molecular architecture of synaptic actin cytoskeleton in hippocampal neurons reveals a mechanism of dendritic spine morphogenesis. Molecular biology of the cell 21(1): 165-76, Jan 2010.

Svitkina Tatyana: Imaging cytoskeleton components by electron microscopy. Methods in molecular biology (Clifton, N.J.) 586: 187-206, 2009.

Yang Changsong, Hoelzle Matthew, Disanza Andrea, Scita Giorgio, Svitkina Tatyana: Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion. PloS one 4(5): e5678, 2009.

Korobova Farida, Svitkina Tatyana: Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells. Molecular biology of the cell 19(4): 1561-74, Apr 2008.

Yang Changsong, Czech Lubov, Gerboth Silke, Kojima Shin-ichiro, Scita Giorgio, Svitkina Tatyana: Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells. PLoS biology 5(11): e317, Nov 2007.

Svitkina Tatyana: Electron microscopic analysis of the leading edge in migrating cells. Methods in cell biology 79: 295-319, 2007.

Vignjevic Danijela, Kojima Shin-ichiro, Aratyn Yvonne, Danciu Oana, Svitkina Tatyana, Borisy Gary G: Role of fascin in filopodial protrusion. The Journal of cell biology 174(6): 863-75, Sep 2006.

Yang Changsong, Pring Martin, Wear Martin A, Huang Minzhou, Cooper John A, Svitkina Tatyana M, Zigmond Sally H: Mammalian CARMIL inhibits actin filament capping by capping protein. Developmental cell 9(2): 209-21, Aug 2005.

Mejillano Marisan R, Kojima Shin-ichiro, Applewhite Derek Anthony, Gertler Frank B, Svitkina Tatyana M, Borisy Gary G: Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell 118(3): 363-73, Aug 2004.

Svitkina Tatyana M, Bulanova Elena A, Chaga Oleg Y, Vignjevic Danijela M, Kojima Shin-ichiro, Vasiliev Jury M, Borisy Gary G: Mechanism of filopodia initiation by reorganization of a dendritic network. The Journal of cell biology 160(3): 409-21, Feb 2003.

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Last updated: 09/02/2009
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