Neal John Sondheimer, M.D. Ph.D.
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
ARC-1012H
The Children's Hospital of Philadelphia
3615 Civic Center Boulevard
Philadelphia, PA 19104
The Children's Hospital of Philadelphia
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-426-5033
Fax: 215-590-3850
Fax: 215-590-3850
Email:
sondheimer@email.chop.edu
sondheimer@email.chop.edu
Education:
A.B. (Biology)
Harvard University, 1994.
Ph.D. (Molecular Genetics and Cell Biology)
University Of Chicago, 2000.
M.D.
University of Chicago, 2002.
Postdoc (Genetics)
The University of Pennsylvania - Narayan Avadhani (mentor), 2009.
Permanent linkA.B. (Biology)
Harvard University, 1994.
Ph.D. (Molecular Genetics and Cell Biology)
University Of Chicago, 2000.
M.D.
University of Chicago, 2002.
Postdoc (Genetics)
The University of Pennsylvania - Narayan Avadhani (mentor), 2009.
Description of Research Expertise
Mitochondrial genetics, mitochondrial heteroplasmy, mitochondrial transcription, mitochondrial disease.Selected Publications
Ornella Zollo, Valeria Tiranti and Neal Sondheimer: Transcriptional requirements of the distal, heavy strand promoter (HSP2) of mitochondrial DNA. Proceedings of the National Academy of Sciences in press, 2012.Grant S F A, Glessner J T, Bradfield J P, Zhao J, Tirone J E, Berkowitz R I, Hakonarson H, Sondheimer N: Lack of relationship between mitochondrial heteroplasmy or variation and childhood obesity. International journal of obesity (2005) Oct 2011.
Glatz Catherine, D'Aco Kristin, Smith Sabrina, Sondheimer Neal: Mutation in the mitochondrial tRNA(Val) causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes. Mitochondrion 11(4): 615-9, Jul 2011.
Sondheimer Neal, Glatz Catherine E, Tirone Jack E, Deardorff Matthew A, Krieger Abba M, Hakonarson Hakon: Neutral mitochondrial heteroplasmy and the influence of aging. Human molecular genetics 20(8): 1653-9, Apr 2011.
Sondheimer Neal, Fang Ji-Kang, Polyak Erzsebet, Falk Marni J, Avadhani Narayan G: Leucine-rich pentatricopeptide-repeat containing protein regulates mitochondrial transcription. Biochemistry 49(35): 7467-73, Sep 2010.
Guha Manti, Tang Weigang, Sondheimer Neal, Avadhani Narayan G: Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets. Biochimica et biophysica acta 1797(6-7): 1055-1065, Feb 2010.
Marni J Falk, Neal Sondheimer: Mitochondrial Genetic Diseases. Current Opinion in Pediatrics 22: 711-716, November 2010.
Ernst LM., Sondheimer N., Deardorff MA., Bennett MJ., Pawel BR.: The value of the metabolic autopsy in the pediatric hospital setting. Journal of Pediatrics 148(6): 779-83, Jun 2006.
Liu JJ., Sondheimer N., Lindquist SL.: Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+] Proceedings of the National Academy of Sciences of the United States of America 99 Suppl 4: 16446-53, Dec 10 2002.
Sondheimer N., Lindquist S.: Rnq1: an epigenetic modifier of protein function in yeast. Molecular Cell 5(1): 163-72, Jan 2000.