Katalin Susztak, MD, PhD

faculty photo
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Renal Electrolyte and Hypertension Division
415 Curie Boulevard
Clinical Research Building 405B
Philadelphia, PA 19104
Office: 215 898 2009
Lab: 215 898 2008
Education:
MD
Semmelweis University, Medical School, Budapest, Hungary, 1995.
PhD
Semmelweis University, Medical School, Budapest, Hungary, 1997.
MS
Albert Einstein College of Medicine, Bronx, NY, 2004.
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Description of Research Expertise

Research interest
Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development.

Keywords
Chronic Kidney Disease
Diabetic Kidney Disease
Tissue fibrosis
Genomics
Epigenomics
Notch, Wnt/Ctnnb1
Epithelial cell differentiation

Research details

Work in my laboratory is aimed towards the understanding of molecular pathways that govern chronic kidney disease development. We have two general areas of interest: hypothesis generating (high trough-put, translational) and mechanistic studies. Over the past 10 years we banked and analyzed (combined genetic, epigenetic and genomic approaches) a large number of healthy and diseased human kidney tissue samples. We hypothesize that integrative analysis of epigenetic and genetic settings in diseased cells can provide a rational basis for more accurately modeling the critical biological pathways involved in mediating the progressive phenotype in individual patients. We also predict that epigenomic integrative analysis can be used to determine the identity of chromatin and transcription factors that contribute mechanistically to aberrant transcriptional programming in chronic kidney disease, and that this information can be used for designing therapeutic strategies. We are specifically interested in defining cis-regulatory modules (promoters, enhancers and repressors) that govern the normal and altered epithelial phenotype in diseased kidneys.
In addition, we use genetic approaches and mouse as a model organism to test the role of candidate signaling molecules and regulatory pathways directly in vivo. The Cre/loxP and tet inducible transgenic technologies allow us to analyze the function of particular factors by deleting or overexpressing genes that encode them in specific cell types in the kidney. Specifically, we are working on determining the role of the Notch and Wnt/beta-catenin pathway in chronic kidney disease development, renal epithelial cell homeostasis, renal stem or progenitor cell function and differentiation. Our recent results highlight the role of embryonic programs in adult disease development.

Rotation Projects
There are several; please speak with Dr. Susztak.

Lab Personnel:

Jianling Tao MD- Visiting Associate Professor
Kimberley Reidy MD- Adjunct Assistant Professor
Esther Park MD - Postdoctoral fellow
Hyun Mi Kang PhD- Postdoctoral fellow
Mariya Sweetwyne PhD- Postdoctoral fellow
Laura Malaga MD, PhD-Fellow
Yi-an Ko- Graduate Student
Frank Chinga- Research Specialist
Nora Ledo- Research Specialist

Selected Publications:

Niranjan T, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K.
The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med. 2008 Mar;14(3):290-8. Epub 2008 Mar 2. PMID: 18311147

Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM, Faul C, Millar SE, Holzman LB, Susztak K. Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem. 2011 Jul 22;286(29):26003-15. PMID: 21613219

Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest. 2010 Nov;120(11):4040-54. PMID: 20978353

Sirin Y, Susztak K. Notch in the kidney: development and disease.
J Pathol. 2012 Jan;226(2):394-403 Review.

Woroniecka KI, Park AS, Mohtat D, Thomas DB, Pullman JM, Susztak K. Transcriptome analysis of human diabetic kidney disease. Diabetes. 2011 Sep;60(9):2354-69.

Selected Publications

Edeling Maria, Ragi Grace, Huang Shizheng, Pavenstädt Hermann, Susztak Katalin: Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog. Nature reviews. Nephrology 12(7): 426-39, Jul 2016.

Breyer Matthew D, Susztak Katalin: The next generation of therapeutics for chronic kidney disease. Nature reviews. Drug discovery May 2016.

Lin Jamie S, Susztak Katalin: Podocytes: the Weakest Link in Diabetic Kidney Disease? Current diabetes reports 16(5): 45, May 2016.

Akchurin Oleh, Du Zhongfang, Ramkellawan Nadira, Dalal Vidhi, Han Seung Hyeok, Pullman James, Müsch Anne, Susztak Katalin, Reidy Kimberly J: Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development. Journal of the American Society of Nephrology : JASN May 2016.

Li Szu Yuan, Susztak Katalin: Fat Burning Problem in Cystic Kidneys: an Emerging Common Mechanism of Chronic Kidney Disease. EBioMedicine 5: 22-3, Mar 2016.

Teumer Alexander, Tin Adrienne, Sorice Rossella, Gorski Mathias, Yeo Nan Cher, Chu Audrey Y, Li Man, Li Yong, Mijatovic Vladan, Ko Yi-An, Taliun Daniel, Luciani Alessandro, Chen Ming-Huei, Yang Qiong, Foster Meredith C, Olden Matthias, Hiraki Linda T, Tayo Bamidele O, Fuchsberger Christian, Dieffenbach Aida Karina, Shuldiner Alan R, Smith Albert V, Zappa Allison M, Lupo Antonio, Kollerits Barbara, Ponte Belen, Stengel Bénédicte, Krämer Bernhard K, Paulweber Bernhard, Mitchell Braxton D, Hayward Caroline, Helmer Catherine, Meisinger Christa, Gieger Christian, Shaffer Christian M, Müller Christian, Langenberg Claudia, Ackermann Daniel, Siscovick David, Boerwinkle Eric, Kronenberg Florian, Ehret Georg B, Homuth Georg, Waeber Gerard, Navis Gerjan, Gambaro Giovanni, Malerba Giovanni, Eiriksdottir Gudny, Li Guo, Wichmann H Erich, Grallert Harald, Wallaschofski Henri, Völzke Henry, Brenner Herrmann, Kramer Holly, Leach I Mateo, Rudan Igor, Hillege J L, Beckmann Jacques S, Lambert Jean Charles, Luan Jian'an, Zhao Jing Hua, Chalmers John, Coresh Josef, Denny Joshua C, Butterbach Katja, Launer Lenore J, Ferrucci Luigi, Kedenko Lyudmyla, Haun Margot, Metzger Marie, Woodward Mark, Hoffman Matthew J, Nauck Matthias, Waldenberger Melanie, Pruijm Menno, Bochud Murielle, Rheinberger Myriam, Verweij N, Wareham Nicholas J, Endlich Nicole, Soranzo Nicole, Polasek Ozren, van der Harst P, Pramstaller Peter Paul, Vollenweider Peter, Wild Philipp S, Gansevoort R T, Rettig Rainer, Biffar Reiner, Carroll Robert J, Katz Ronit, Loos Ruth J F, Hwang Shih-Jen, Coassin Stefan, Bergmann Sven, Rosas Sylvia E, Stracke Sylvia, Harris Tamara B, Corre Tanguy, Zeller Tanja, Illig Thomas, Aspelund Thor, Tanaka Toshiko, Lendeckel Uwe, Völker Uwe, Gudnason Vilmundur, Chouraki Vincent, Koenig Wolfgang, Kutalik Zoltan, O'Connell Jeffrey R, Parsa Afshin, Heid Iris M, Paterson Andrew D, de Boer Ian H, Devuyst Olivier, Lazar Jozef, Endlich Karlhans, Susztak Katalin, Tremblay Johanne, Hamet Pavel, Jacob Howard J, Böger Carsten A, Fox Caroline S, Pattaro Cristian, Köttgen Anna: Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes. Diabetes 65(3): 803-17, Mar 2016.

Reiner Alex P, Susztak Katalin: APOL1 Variants: From Parasites to Kidney Function to Cardiovascular Disease. Arteriosclerosis, thrombosis, and vascular biology 36(2): 219-20, Feb 2016.

Ledo N, Susztak K and Palmer M: Cell Phenotype Transitions in Renal Fibrosis. Current Pathobiology Reports February 2016.

Hakimi A Ari, Ostrovnaya Irina, Jacobsen Anders, Susztak Katalin, Coleman Jonathan A, Russo Paul, Winer Andrew G, Mano Roy, Sankin Alexander I, Motzer Robert J, Voss Martin H, Offit Kenneth, Purdue Mark, Pomerantz Mark, Freedman Matthew, Choueiri Toni K, Hsieh James J, Klein Robert J: Validation and genomic interrogation of the MET variant rs11762213 as a predictor of adverse outcomes in clear cell renal cell carcinoma. Cancer 122(3): 402-10, Feb 2016.

Kang Hyun Mi, Huang Shizheng, Reidy Kimberly, Han Seung Hyeok, Chinga Frank, Susztak Katalin: Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice. Cell reports 14(4): 861-71, Feb 2016.

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Last updated: 07/28/2016
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