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Thomas P. Cappola, MD, ScM

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Professor of Medicine
Attending, Hospital of the University of Pennsylvania, Heart Failure and Transplantation Service
Member, Penn Cardiovascular Institute
Member, Institute for Diabetes, Obesity, and Metabolism
Member, Institute for Translational Medicine and Therapeutics
Member, Penn Genome Frontiers Institute
Programmatic Mentor, Masters in Translational Research Program, University of Pennsylvania Perelman School of Medicine
Chief, Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine
Department: Medicine

Contact information
Perelman Center for Advanced Medicine
Division of Cardiovascular Medicine
11-113 South Pavilion
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-662-3140
Fax: 215-349-8017
Lab: 215-573-4717
Graduate Group Affiliations
Education:
A.B. (Chemistry)
Princeton University, 1991.
M.D. (Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2004.
Post-Graduate Training
Intern and Resident, Internal Medicine, Brigham and Women’s Hospital, 1995-1998.
Clinical and Research Fellow, Cardiovascular Disease, Johns Hopkins Hospital, 1998-2002.
Heart Failure and Transplantation Fellow, Johns Hopkins Hospital, 2000-2001.
Research Fellow, National Heart, Lung, and Blood Institute Program in Genomic Applications, Johns Hopkins Medical Institutions, 2001-2002.
Honorary Senior Visiting Fellow, University of Cambridge, UK, 2013-2014.
Certifications
American Board of Internal Medicine Certification in Internal Medicine , 1998.
American Board of Internal Medicine Certification in Cardiovascular Medicine, 2002.
American Board of Internal Medicine Certification in Advanced Heart Failure and Transplantation, 2010.
American Board of Internal Medicine Certification in Cardiovascular Medicine (Renewal), 2012.
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Selected Publications

Wild P, Janine Felix, Schillert A, Teumer A, Cappola TP, Hirschhorn J, Mitchell GF, Smith N, Fox ER, Dueker ND, Jaddoe VW, Melander O, Russ M, Lehtimäki T, Ciullo M, Hicks A, Lind L, Gudnason V, Pieske B, Barron AJ, Zweiker R, Schunkert H, Ingelsson E, Liu K, Arnett DK, Psaty B, Blankenberg S, Larson M, Felix S, Franco OH, Zeller T, Vasan R, Dörr M: New Genetic variants for Cardiac Structure and Function – The EchoGen Consortium JCI 127(5): 1798-1812, May 2017.

Esslinger U, Garnier S, Korniat A, Proust C, Kararigas G, Müller-Nurasyid M, Empana JP, Morley MP, Perret C, Stark K, Bick AG, Prasad SK, Kriebel J, Li J, Tiret L, Strauch K, O'Regan DP, Marguiles KB, Seidman JG, Boutouyrie P, Lacolley P, Jouven X, Hengstenberg C, Komajda M, Hakonarson H, Isnard R, Arbustini E, Grallert H, Cook SA, Seidman CE, Regitz-Zagrosek V, Cappola TP, Charron P, Cambien F, Villard E: Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. PLoS One 12(3): e0172995, Mar 2017.

Dubin RF, Deo R, Bansal N, Anderson AH, Yang P, Go AS, Keane M, Townsend R, Porter A, Budoff M, Malik S, He J, Rahman M, Wright J, Cappola TP, Kallem R, Roy J, Sha D, Shlipak MG: Associations of conventional echocardiographic measures with incident heart failure and mortality: The Chronic Renal Insufficiency Cohort. Clin J Am Soc Nephrol 12(1): 60-68, Jan 2017.

Zamani P, Tan V, Soto-Calderon H, Beraun M, Brandimarto JA, Trieu L, Varakantam S, Doulias P, Townsend RR, Chittams J, Margulies KB, Cappola TP, Poole DC, Ischiropoulos H, Chirinos JA: Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction. Circ Research Dec 2016 Notes: In Press.

Zamani P, French B, Brandimarto JA; Douliasm P, Javaheri A, Chirinos JA, Margulies KB, Townsend RR, Sweitzer NK, Fang JC; Ischiropoulos H, Cappola TP: Effect of heart failure with preserved ejection fraction on nitric oxide metabolites. Am J Cardiol 118(12): 1855-1860, Dec 2016.

Chirinos JA, Akers SR, Trieu L; Ischiropoulos H, Paschalis-Thomas D, Tariq A, Vassim I, Maheswara KR, Syed AA, Soto-Calderon H, Townsend RR Cappola TP, Margulies KB, Zamani P: Heart failure, left ventricular remodeling, and circulating nitric oxide metabolites. J Am Heart Assoc 5(10): e004133, Oct 2016.

Margulies KB, Hernandez A, Redfield M, Givertz M, Oliveira G, Cole R, Mann D, Whellan D, Kiernan M, Felker GM, McNulty S, Anstrom K, Shah S, Eugene Braunwald E, Cappola TP: Effects of liraglutide on clinical stability in advanced heart failure with reduced ejection fraction: a randomized clinical trial. JAMA 316(5): 500-508, Aug 2016.

AbouEzzeddine OF, French B, Mirzoyev SA, Jaffe AS, Levy WC, Fang JC, Sweitzer NK, Cappola TP, Redfield MM: From statistical significance to clinical relevance: a simple algorithm to integrate brain natriuretic peptide and the Seattle Heart Failure Model for risk stratification in heart failure. J Heart Lung Transplant 35(6): 714-21, Jun 2016 Notes: Epub 2016 Jan 15.

Smith JG, Felix J, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlöf O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, Sjögren M, Ngwa J, Brandimarto J, Stott D, Aguilar D, Rice KM, Sesso HD, Demissie S, Buckley BM, Taylor KD, Ford I, Yao C, Liu C, Sotoodehnia N, van der Harst P, Stricker BHC, Kritchevsky SB, Liu Y, Gaziano JM, Hofman A, Moravec CS, Uitterlinden AG, Kellis M, van Meurs JB, Margulies KB, Dehghan A, Levy D, Olde B, Psaty BM, Cupples LA, Jukema J, Djousse L, Franco OH, Boerwinkle E, Boyer LA, Newton-Cheh C, Butler J, Vasan R, Cappola TP, Smith NL: Discovery of genetic variation on chromosome 5q22 associated with mortality in heart failure. PLoS Genet 12(5): e1006034, May 2016.

French B, Wang L, Ky B, Brandimarto J, Basuray A, Fang JC, Sweitzer NK, Cappola TP: Prognostic value of galectin-3 for adverse outcomes in chronic heart failure. J Card Fail 22(4): 256-62, Apr 2016.

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Last updated: 06/05/2017
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