Penn Transplant Institute

Transplant Faculty

Thomas P. Cappola, M.D., Sc.M.

faculty photo
Herbert C. Rorer Associate Professor in Medical Sciences
Attending, Hospital of the University of Pennsylvania, Heart Failure and Transplantation Service
Director, Heart Failure Clinical Research, Penn Cardiovascular Institute
Member, Penn Cardiovascular Institute
Member, Institute for Diabetes, Obesity, and Metabolism
Member, Institute for Translational Medicine and Therapeutics
Member, Penn Genome Frontiers Institute
Chief, Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine
Department: Medicine

Contact information
Division of Cardiovascular Medicine
9035 West Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3140
Fax: 215-349-8017
Lab: 215-573-4717
Graduate Group Affiliations
Education:
A.B. (Chemistry)
Princeton University, 1991.
M.D. (Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2004.
Post-Graduate Training
Intern and Resident, Internal Medicine, Brigham and Women’s Hospital, 1995-1998.
Clinical and Research Fellow, Cardiovascular Disease, Johns Hopkins Hospital, 1998-2002.
Heart Failure and Transplantation Fellow, Johns Hopkins Hospital, 2000-2001.
Research Fellow, National Heart, Lung, and Blood Institute Program in Genomic Applications, Johns Hopkins Medical Institutions, 2001-2002.
Honorary Senior Visiting Fellow, University of Cambridge, UK, 2013-2014.
Certifications
American Board of Internal Medicine Certification in Internal Medicine , 1998.
American Board of Internal Medicine Certification in Cardiovascular Medicine, 2002.
American Board of Internal Medicine Certification in Advanced Heart Failure and Transplantation, 2010.
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Selected Publications

Keenan T, Zhao W, Rasheed A, Ho WK, Malik R, Felix JF, Young R, Shah N, Samuel M, Sheikh N, Mucksavage ML, Shah O, Li J, Morley M, Laser A, Mallick NH, Zaman KS, Ishaq M, Rasheed SZ, Memon FU, Ahmed F, Hanif B, Lakhani MS, Fahim M, Ishaq M, Shardha NK, Ahmed N, Mahmood K, Iqbal W, Akhtar S, Raheel R, O'Donnell CJ, Hengstenberg C, März W, Kathiresan S, Samani N, Goel A, Hopewell JC, Chambers J, Cheng YC, Sharma P, Yang Q, Rosand J, Boncoraglio GB, Kazmi SU, Hakonarson H, Köttgen A, Kalogeropoulos A, Frossard P, Kamal A, Dichgans M, Cappola T, Reilly MP, Danesh J, Rader DJ, Voight BF, Saleheen D: Causal assessment of serum rrate levels in cardiometabolic diseases through a Mendelian randomization study. J Am Coll Cardiol 2(67): 407-16, Feb 2016.

Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J 3rd, McNamara DM, Seidman CE, Seidman JG, Arany Z: Shared genetic predisposition in peripartum and dilated cardiomyopathies. N Engl J Med 374(3): 233-41, Jan 2016.

Perez MV, Pavlovic A, Shang C, Wheeler MT, Miller CL, Liu J, Dewey FE, Pan S, Thanaporn PK, Absher D, Brandimarto J, Salisbury H, Chan K, Mukherjee R, Konadhode RP, Myers RM, Sedehi D, Scammell TE, Quertermous T, Cappola T, Ashley EA: Systems genomics identifies a key role for hypocretin/orexin receptor-2 in human heart failure. J Am Coll Cardiol 66(22): 2522-33, Dec 2015.

French B, Wang L, Ky B, Brandimarto J, Basuray A, Fang JC, Sweitzer NK, Cappola TP: Prognostic Value of Galectin-3 for Adverse Outcomes in Chronic Heart Failure. J Card Fail Epub ahead of print, Nov 2015.

Jia C, Guan W, Yang A, Xiao R, Tang WH, Moravec CS, Margulies KB, Cappola TP, Li M, Li C: MetaDiff: differential isoform expression analysis using random-effects meta-regression. BMC Bioinformatics 16(208): doi: 10.1186/s12859-015-0623-z, Jul 2015.

Givertz MM, Anstrom KJ, Redfield MM, Deswal A, Haddad H, Butler J, Tang WH, Dunlap ME, LeWinter MM, Mann DL, Felker GM, O'Connor CM, Goldsmith SR, Ofili EO, Saltzberg MT, Margulies KB, Cappola TP, Konstam MA, Semigran MJ, McNulty SE, Lee KL, Shah MR, Hernandez AF: Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. Circulation 131(20): 1763-71, May 2015.

Liu Y, Morley M, Brandimarto J, Hannenhalli S, Hu Y, Ashley EA, Tang WH, Moravec CS, Margulies KB, Cappola TP, Li M; for the MAGNet consortium: RNA-Seq identifies novel myocardial gene expression signatures of heart failure. Genomics 105(2): 83-89, Feb 2015.

Tampakakis E, Leary PJ, Selby VN, De Marco T, Cappola TP, Felker GM, Russell SD, Kasper EK, Tedford RJ : The diastolic pulmonary gradient does not predict survival in patients with pulmonary hypertension due to left heart disease. JACC Heart Fail 3(1): 9-16, Jan 2015.

Zamani P, Rawat D, Shiva-Kumar P, Geraci S, Bhuva R, Konda P, Doulias PT, Ischiropoulos H, Townsend RR, Margulies KB, Cappola TP, Poole DC, Chirinos JA : Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction. Circulation 131(4): 371-80, Jan 2015.

Zhang R, Zhang Y, An T, Guo X, Yin S, Wang Y, Januzzi JL, Cappola TP, Zhang J: Prognostic value of sST2 and galectin-3 for death relative to renal function in patients hospitalized for heart failure. Biomark Med 9(5): 433-41, 2015.

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Last updated: 02/10/2016
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