Lewis A. Chodosh
Professor of Cancer Biology
Department: Cancer Biology
Graduate Group Affiliations
Contact information
612 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 898-1321
Fax: (215) 573-6725
Lab: (215) 898-0006
Fax: (215) 573-6725
Lab: (215) 898-0006
Email:
chodosh@mail.med.upenn.edu
chodosh@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Department of Cancer Biology
Abramson Family Cancer Research Institute
Cell and Molecular Biology graduate group faculty webpage.
Search PubMed for articles
Department of Cancer Biology
Abramson Family Cancer Research Institute
Cell and Molecular Biology graduate group faculty webpage.
Education:
B.S. (Molecular Biophysics & Biochemistry)
Yale University, 1981.
Ph.D. (Biochemistry)
Massachusetts Institute of Technology, 1988.
M.D.
Harvard Medical School, 1989.
Permanent linkB.S. (Molecular Biophysics & Biochemistry)
Yale University, 1981.
Ph.D. (Biochemistry)
Massachusetts Institute of Technology, 1988.
M.D.
Harvard Medical School, 1989.
Description of Research Expertise
Research InterestsGenetically engineered mouse models for breast cancer initiation, metastasis, and recurrence.
Normal developmental biology of the mammary gland.
Tumor dormancy.
Stem cells in breast cancer and mammary development.
Oncogenes and tumor suppressors in breast cancer.
Genomics and computational biology.
Non-invasive imaging.
Key words: Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging.
Description of Research
Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide. The Chodosh laboratory uses genetically engineered mouse models to study the genes and mechanisms that cause breast cancer and that regulate normal mammary gland development. Particular areas of interest include: the function of oncogenes and tumor suppressor genes in breast cancer, metastasis, tumor dormancy and recurrence; the role of stem cells in cancer and the normal development of the mammary gland; the use of genomics and computational approaches to understand genetic programs in mammary development and breast cancer; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches such as PET, MRI, and bioluminescence to study tumor biology. These approaches employ a broad array of molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in mammary gland and tumor biology.
Rotation Projects for 2012-2013
Rotation projects are available in each of the main areas of the lab.
Lab personnel:
James V. Alvarez, Ph.D. - Research Project Manager
Daniel Abravanel - Graduate Student
Chien-Chung Chen, Ph.D. - Research Project Manager
Dania Daye - Graduate Student
Samantha Eberle - Graduate Student
Yi Feng, Ph.D. - Postdoctoral Fellow
Samuel Getchell - Graduate Student
Ann Vernon Grey, Ph.D. - Postdoctoral Fellow
Jason Jung - Graduate Student
Heather Martin, Ph.D. - Postdoctoral Fellow
Jason Ruth - Graduate Student
Lauren Smith - Graduate Student
Ania Warczyk - Graduate Student
Elizabeth Yeh, Ph.D. - Postdoctoral Fellow
Selected Publications
Qu W, Oya S, Lieberman BP, Ploessl K, Wang L, Wise DR, Divgi CR, Chodosh L, Thompson CB, and Kung HF: Preparation and characterization of L-[5-11C]-Glutamine for metabolic imaging of tumors. Journal of Nuclear Medicine 53: 98-105, 2012.Lieberman BP, Ploessl K, Wang L, Qu W, Zha Z, Wise DR, Seidel H, Belka G, Chodosh LA, Thompson CB and Kung HF: PET imaging of glutaminolysis in tumors by [18F](2S,4R)4-fluoro-glutamine. Journal of Nuclear Medicine 52: 1947-1955, 2011.
Yori JL, Seachrist DD, Johnson E, Lozada KL, Abdul-Karim FW, Chodosh LA, Schiemann WP, Keri RA: Krüppel-like Factor 4 Inhibits Tumorigenic Progression and Metastasis in a Mouse Model of Breast Cancer. Neoplasia 13(7): 601-10, 2011.
Brown RL, Reinke LM, Damerow MS, Perez D, Chodosh LA, Yang J, Cheng C: CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. Journal of Clinical Investigation 121(3): 1064-74, 2011.
Whiteaker JR, Lin C, Kennedy J, Hou L, Trute M, Sokal I, Yan P, Schoenherr RM, Zhao L, Voytovich UJ, Kelly-Spratt KS, Krasnoselsky A, Gafken PR, Hogan JM, Jones LA, Wang P, Amon L, Chodosh LA, Nelson PS, McIntosh MW, Kemp CJ, Paulovich AG: A targeted proteomics-based pipeline for verification of biomarkers in plasma. Nature Biotechnology 29(7): 625-34, 2011.
Schoenherr R, Kelly-Spratt K, Lin C, Whiteaker J, Liu T, Holzman T, Coleman I, Feng LC, Lorentzen T, Krasnoselsky A, Wang P, Liu Y, Gurley K, Amon L, Schepmoes A, Moore R, Camp D, Chodosh L, Smith R, Nelson P, McIntosh M, Kemp C, Paulovich A: Proteome and transcriptome profiles of a Her2/Neu-driven mouse model of breast cancer. Proteomics Clinical Applications 5(3-4): 179-88, 2011.
Alvarez JV, Yeh ES, Feng Y, and Chodosh LA: Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies. Genetically-engineered Mice for Cancer Research: design, analysis, pathways, validation and pre-clinical testing 2011.
Chodosh LA: Breast cancer: current state and future promise. Breast Cancer Research 13: 113, 2011.
Zhang XY, Pfeiffer HK, Mellert HS, Stanek TJ, Sussman RT, Kumari A, Yu D, Rigoutsos I, Thomas-Tikhonenko A, Seidel HE, Chodosh LA, Packham G, Baserga R, McMahon SB: Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC. Molecular and Cellular Biology 31: 5037-5045, 2011.
Markosyan N, Chen E, Ndong V, Yao Y, Sterner CJ, Chodosh LA, Lawson JA, Fitzgerald GA and Smyth EM: Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. Carcinogenesis 32: 1441-1449, 2011.