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Edward Stuart Brodkin, M.D.
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Associate Professor of Psychiatry
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Department: Psychiatry
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Graduate Group Affiliations
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Contact information
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Center for Neurobiology and Behavior
20 Department of Psychiatry
45 Perelman School of Medicine at the University of Pennsylvania
34 Translational Research Laboratory, Room 2202
3d 125 South 31st Street
Philadelphia, PA 19104-3403
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20 Department of Psychiatry
45 Perelman School of Medicine at the University of Pennsylvania
34 Translational Research Laboratory, Room 2202
3d 125 South 31st Street
Philadelphia, PA 19104-3403
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Office: (215)-746-0118
34 Fax: (215)-573-2041
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34 Fax: (215)-573-2041
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Links
ae Brodkin webpage for University of Pennsylvania Department of Psychiatry
68 Brodkin research homepage
74 Brodkin clinical expertise website
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ae Brodkin webpage for University of Pennsylvania Department of Psychiatry
68 Brodkin research homepage
74 Brodkin clinical expertise website
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Education:
21 9 A.B. 1f (History of Science) c
2b Harvard University, 1988.
21 9 M.D. 15 (Medicine) c
2f Harvard Medical School, 1992.
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Permanent link21 9 A.B. 1f (History of Science) c
2b Harvard University, 1988.
21 9 M.D. 15 (Medicine) c
2f Harvard Medical School, 1992.
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d8 Treatments to enhance social functioning in adults with autism spectrum disorders. Neurobiology and genetics of of social behavior development, and neurobiology and genetics of autism and spectrum disorders.
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10 KEYWORDS
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73 autism; social; functioning; skills; behavior; motivation; emotion; genetics; genomics; neurobiology; brain
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1b RESEARCH TECHNIQUES
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13b Measurement of social motivation, social approach, and social interactions in humans and animal models; behavioral genetics, genetic mapping, quantitative trait locus (QTL) analysis; neurobiological studies of social behavior phenotypes; psychosocial and biological treatments to improve social functioning.
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18 RESEARCH SUMMARY
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2ad Our laboratory is interested in the neurobiological and genetic mechanisms of social behavior development, as well as biological mechanisms underlying social motivation, social learning, and social skill acquisition and generalization. Certain highly heritable neuropsychiatric disorders, including autism and schizophrenia spectrum disorders, are characterized by reduced social motivation, increased social anxiety, disruptions in social learning, and impairment in social skill development. Despite its importance, the fundamental biology of these social processes is not well understood, and currently available treatments for these social behavior domains are inadequate.
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1f0 Our current projects include the following: 1) Studies of treatments to enhance social motivation, social understanding, and social skills and reduce social anxiety in adults with autism spectrum disorder (ASD); 2) neural and genetic biomarkers in adults with ASD, 3) studies of the neurobiology and genetics of individual differences in social-emotional behavior development in humans and mouse models; 3) studies of gene-environment interactions in shaping social-emotional development.
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Description of Research Expertise
23 RESEARCH INTERESTS8
d8 Treatments to enhance social functioning in adults with autism spectrum disorders. Neurobiology and genetics of of social behavior development, and neurobiology and genetics of autism and spectrum disorders.
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10 KEYWORDS
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73 autism; social; functioning; skills; behavior; motivation; emotion; genetics; genomics; neurobiology; brain
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1b RESEARCH TECHNIQUES
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13b Measurement of social motivation, social approach, and social interactions in humans and animal models; behavioral genetics, genetic mapping, quantitative trait locus (QTL) analysis; neurobiological studies of social behavior phenotypes; psychosocial and biological treatments to improve social functioning.
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18 RESEARCH SUMMARY
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2ad Our laboratory is interested in the neurobiological and genetic mechanisms of social behavior development, as well as biological mechanisms underlying social motivation, social learning, and social skill acquisition and generalization. Certain highly heritable neuropsychiatric disorders, including autism and schizophrenia spectrum disorders, are characterized by reduced social motivation, increased social anxiety, disruptions in social learning, and impairment in social skill development. Despite its importance, the fundamental biology of these social processes is not well understood, and currently available treatments for these social behavior domains are inadequate.
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1f0 Our current projects include the following: 1) Studies of treatments to enhance social motivation, social understanding, and social skills and reduce social anxiety in adults with autism spectrum disorder (ASD); 2) neural and genetic biomarkers in adults with ASD, 3) studies of the neurobiology and genetics of individual differences in social-emotional behavior development in humans and mouse models; 3) studies of gene-environment interactions in shaping social-emotional development.
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Description of Clinical Expertise
4f Diagnosis and treatment of autism spectrum disorders in adults.1a 29
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139 Dow H.C., Kreibich A.S., Kaercher K.A., Sankoorikal G.M.V., Pauley E.D., Lohoff F.W., Ferraro T.N., Li H., Brodkin E.S.: Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice. Genes, Brain and Behavior 10: 57-68, 2011.
14e Fairless A.H., Dow H.C., Toledo M.M., Malkus K.A., Edelmann M., Li H., Talbot K., Arnold S.E., Abel T., Brodkin E.S.: Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain. Brain Research 1230: 211-217, 2008.
10b Brodkin E.S.: Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (2008). Behavioral Neuroscience 122: 483-489, 2008.
109 Brodkin E.S.: BALB/cJ mice: low sociability and other phenotypes that may be relevant to autism. Behavioural Brain Research (Special Issue on “Animal Models for Autism”) 176: 53-65, 2007.
11f Sankoorikal G.M.V., Kaercher K.A., Boon C.J., Lee J.K., Brodkin E.S. : A mouse model system for genetic analysis of sociability: C57BL/6J vs. BALB/cJ inbred mouse strains. Biological Psychiatry 59: 415-423, 2006.
fe Gillihan S.J., Farah M.J., Sankoorikal G.M.V., Breland J., Brodkin E.S.: Association between serotonin transporter genotype and extraversion. Psychiatric Genetics 17: 351-354, 2007.
f3 Brodkin E.S., Hagemann A., Nemetski S.M., Silver L.M. : Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice. Brain Research 1002: 151-157, 2004.
10c Brodkin E.S., Goforth S.A., Keene A.H., Fossella J.A., Silver L.M.: Identification of quantitative trait loci that affect aggressive behavior in mice. Journal of Neuroscience 22: 1165-1170, 2002.
fe Carlezon W.A., Thome J., Olson V.G., Lane-Ladd S.B., Brodkin E.S., Hiroi N., Duman R.S., Neve R.L., Nestler E.J.: Regulation of cocaine reward by CREB. Science 282: 2272-2275, 1998.
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Selected Publications
146 Fairless A.H., Shah R.Y., Guthrie A.J., Li H., Brodkin E.S.: Deconstructing sociability, an autism-relevant phenotype, in mouse models. The Anatomical Record (Special Issue: “New Concepts in Developing Brain Disorders--Autism”) 294: 1713-1725, 2011.139 Dow H.C., Kreibich A.S., Kaercher K.A., Sankoorikal G.M.V., Pauley E.D., Lohoff F.W., Ferraro T.N., Li H., Brodkin E.S.: Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice. Genes, Brain and Behavior 10: 57-68, 2011.
14e Fairless A.H., Dow H.C., Toledo M.M., Malkus K.A., Edelmann M., Li H., Talbot K., Arnold S.E., Abel T., Brodkin E.S.: Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain. Brain Research 1230: 211-217, 2008.
10b Brodkin E.S.: Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (2008). Behavioral Neuroscience 122: 483-489, 2008.
109 Brodkin E.S.: BALB/cJ mice: low sociability and other phenotypes that may be relevant to autism. Behavioural Brain Research (Special Issue on “Animal Models for Autism”) 176: 53-65, 2007.
11f Sankoorikal G.M.V., Kaercher K.A., Boon C.J., Lee J.K., Brodkin E.S. : A mouse model system for genetic analysis of sociability: C57BL/6J vs. BALB/cJ inbred mouse strains. Biological Psychiatry 59: 415-423, 2006.
fe Gillihan S.J., Farah M.J., Sankoorikal G.M.V., Breland J., Brodkin E.S.: Association between serotonin transporter genotype and extraversion. Psychiatric Genetics 17: 351-354, 2007.
f3 Brodkin E.S., Hagemann A., Nemetski S.M., Silver L.M. : Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice. Brain Research 1002: 151-157, 2004.
10c Brodkin E.S., Goforth S.A., Keene A.H., Fossella J.A., Silver L.M.: Identification of quantitative trait loci that affect aggressive behavior in mice. Journal of Neuroscience 22: 1165-1170, 2002.
fe Carlezon W.A., Thome J., Olson V.G., Lane-Ladd S.B., Brodkin E.S., Hiroi N., Duman R.S., Neve R.L., Nestler E.J.: Regulation of cocaine reward by CREB. Science 282: 2272-2275, 1998.
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