Faculty

Brian Litt, MD

Perelman Professor of Neurology

Department: Neurology

Graduate Group Affiliations

Contact information

Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104

Office: (215) 746-4850
Fax: (215)-349-5733

Email:
littb@pennmedicine.upenn.edu

Publications

Search PubMed for articles

Education:
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.

Links
Search PubMed for articles
Center for Neuroengineering and Therapeutics
Lab Web Page
Institute of Neurological Sciences Faculty
PennBrain
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System, “See-Through, One-Atom-Thick, Carbon Electrodes are a Powerful Tool for Studying Epilepsy, Other Brain Disorders, Penn Study Finds”
Penn Center for Health, Devices & Technology (Penn Health-Tech)
Penn Neuroengineering Research Lab

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Description of Clinical Expertise

Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEG

Description of Other Expertise

Entrepreneurship:

I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000

I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.

I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).

I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)

I have participated in helping bring several implantable NeuroDevices to market.

Selected Publications

Lucas A, Campbell Arnold T, Okar SV, Vadali C, Kawatra KD, Ren Z, Cao Q, Shinohara RT, Schindler MK, Davis KA, Litt B, Reich DS, Stein JM.: Multi-contrast high-field quality image synthesis for portable low-field MRI using generative adversarial networks and paired data. Radiology in revision, May 2024.

Gallagher RS, Sinha N, Pattnaik AR, Ojemann WKS, Lucas A, LaRocque JJ, Bernabei JM, Greenblatt AS, Sweeney EM, Chen HI, Davis KA, Conrad EC, Litt B.: Quantifying interictal intracranial EEG to predict focal epilepsy. Brain Communications in press, May 2024.

Xie K, Ojemann WKS, Gallagher RS, Lucas A, Hill CE, Hamilton RH, Johnson KB, Roth D, Litt B, Ellis CA.: Disparities in seizure outcomes revealed by large language models. Journal Am Med Inform Assoc. 13(ocae047), March 2024 Notes: doi: 10.1093/jamia/ocae047.

Lucas A, Scheid BH, Pattnaik AR, Gallagher R, Mojena M, Tranquille A, Prager B, Gleichgerrcht E, Gong R, Litt B, Davis KA, Das S, Stein JM, Sinha N.: iEEG-recon: A Fast and Scalable Pipeline for Accurate Reconstruction of Intracranial Electrodes and Implantable Devices. Epilepsia Dec 2023.

Emmert BE, Xie K, Conrad EC, Ghosn NJ, Bauman K, Korzun J, Kulick-Soper CV, Naveed O, Hartmann N, LaRocque JJ, Mindy Ganguly T, Gugger JJ, Raghupathi R, Gelfand MA, Davis KA, Sinha SR, Litt B, Shinohara RT, Ellis CA.: Alcohol for seizure induction in the epilepsy monitoring unit. Epilepsy Behav 150: 109572, Dec 2023.

Knight A, Gschwind T, Galer P, Worrell GA, Litt B, Soltesz I, Beniczky S.: Artificial Intelligence in Epilepsy Phenotyping. Epilepsia Nov 2023.

Pattnaik AR, Ghosn NJ, Ong IZ, Revell AY, Ojemann WKS, Scheid BH, Georgostathi G, Bernabei JM, Conrad EC, Sinha SR, Davis KA, Sinha N, Litt B.: The seizure severity score: a quantitative tool for comparing seizures and their response to therapy. J Neural Eng 20, Aug 2023.

Xie K, Terman SW, Gallagher RS, Hill CE, Davis KA, Litt B, Roth D, Ellis CA.: Generalization of finetuned transformer language models to new clinical contexts. JAMIA Open 6: ooad070, Aug 2023.

Ojemann WKS, Scheid BH, Mouchtaris S, Lucas A, LaRocque JJ, Aguila C, Ashourvan A, Caciagli L, Davis KA, Conrad EC, Litt B.: Resting-state background features demonstrate multidien cycles in long-term EEG device recordings. Brain Stimul Jul 2023.

Bernabei JM, Litt B, Cajigas I.: Thalamic stereo-EEG in epilepsy surgery: where do we stand? Brain 146: 2663-2665, Jul 2023.