Joshua R Friedman
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
Abramson Pediatric Research Center
ARC 902G
3615 Civic Center Blvd.
Philadelphia, PA 19104
ARC 902G
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-7223
Fax: 206-984-2191
Lab: 215-590-2047
Fax: 206-984-2191
Lab: 215-590-2047
Email:
friedmaj@mail.med.upenn.edu
friedmaj@mail.med.upenn.edu
Education:
AB (Biochemistry)
Harvard University, 1991.
PhD (Cell and Molecular Biology)
University of Pennsylvania, 1996.
MD
University of Pennsylvania, 1998.
Permanent linkAB (Biochemistry)
Harvard University, 1991.
PhD (Cell and Molecular Biology)
University of Pennsylvania, 1996.
MD
University of Pennsylvania, 1998.
Description of Research Expertise
Research InterestsMy laboratory conducts basic and translational research on microRNA in pediatric gastrointestinal and liver development and disease.
Keywords
Liver development, microRNA, biliary atresia, cholestasis, fibrosis, inflammatory bowel disease, eosinophilic esophagitis.
Research details
1) MicroRNA in biliary atresia
Goal: to determine if microRNA plays a functional role in biliary atresia, using clinical samples, a mouse model of the disease, and cell culture tools.
2) MicroRNA in cholestatic liver disease
Goal: to understand how microRNA promotes the adaptive response to cholestasis.
3) MicroRNA in liver development
Goal: to determine if miRNA functions in liver development, particularly biliary specification and morphogenesis.
4) MicroRNA as a biomarker for gastrointestinal and liver disease.
Goal: to utilize circulating and tissue miRNA levels as diagnostic and prognostic biomarkers for diseases such as biliary atresia, inflammatory bowel disease, and eosinophilic esophagitis.
Rotation projects
MicroRNA target identification (several relevant miRNAs available)
Genetic models of specific miRNA deficiency
Functional analysis of miRNA in a cell culture model of biliary differentiation
Lab personnel
Nick Hand, Scientist
Adam Zahm, Post-doctoral Fellow
Claire Le Guen, Technician
Scott Gordon, MD/PhD student (post-PhD)
Selected Publications
Karjoo S, Hand NJ, Loarca L, Russo PA, Friedman JR, Wells RG: Extra-hepatic cholangiocyte cilia are abnormal in biliary atresia Journal of Pediatric Gastroenterology and Nutrition April 2013 Notes: Epub ahead of print.Schug J, McKenna LB, Walton G, Hand N, Mukherjee S, Essuman K, Shi Z, Gao Y, Markley K, Nakagawa M, Kameswaran V, Vourekas A, Friedman JR, Kaestner KH, Greenbaum LE: Dynamic Recruitment of microRNAs to their mRNA Targets in the Regenerating liver. BMC Genomics 14(1): 264, April 2013.
Zahm, AM, Hand, NJ, Boateng, LA, Friedman, JR: Circulating MicroRNA is a Biomarker of Biliary Atresia. Journal of Pediatric Gastroenterology and Nutrition 55(4): 366-9, October 2012.
Venneti S, Boateng LA, Friedman JR, Baldwin DA, Tobias JW, Judkins AR, Mourelatos Z, Lal P: MiRNA-9 and miRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. Brain Pathology 22(4): 522-529, July 2012.
Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang K-M, Artis D: Innate lymphoid cells orchestrate anatomical containment of lymphoid-resident commensal bacteria and prevent systemic immune activation. Science 336(6086): 1321-1325, June 2012.
Hand NJ, Horner AM, Master ZR, Boateng LA, LeGuen C, Uvaydova M, Friedman JR: MicroRNA profiling identifies miR-29 as a regulator of disease-associated pathways in experimental biliary atresia. Journal of Pediatric Gastroenterology and Nutrition 54(2): 186-192, February 2012.
Zahm AM, Thayu M, Hand NJ, Horner A, Leonard MB, Friedman JR: Circulating microRNA is a biomarker of pediatric Crohn disease. Journal of Pediatric Gastroenterology and Nutrition 53(1): 26-33, July 2011.
Laje P, Clark FH, Friedman JR, Flake AW: Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary atresia. J Pediatr Surg 45(9): 1791-6, Sep 2010.
McKenna LB, Schug J, Vourekas A, McKenna JB, Bramswig N, Friedman JR, Kaestner KH: MicroRNAs Control Intestinal Epithelial Differentiation, Architecture, and Barrier Function. Gastroenterology 139(5): 1654-1664, Jul 2010.
Hand NJ, Master ZR, EauClaire SF, Weinblatt DE, Matthews RP, Friedman JR: The microRNA-30 family is required for vertebrate hepatobiliary development Gastroenterology 136(3): 1081-1090. PMCID: PMC2672911 March 2009.