Muredach P. Reilly

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Translational Research Center
3400 Civic Center Blvd, Bldg 421
11th Floor, Room 11-136
Philadelphia, PA 19104
Office: (215) 573-1214
Lab: (215) 573-0224
Education:
MBBCh (Medicine)
University College, Dublin, Ireland, 1988.
BS (Pharmacology)
University College Dublin, Ireland , 1990.
MSCE (Epidemiology and Biostatistics)
University of Pennsylvania, 2003.
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Description of Research Expertise

My group focuses on preclinical cell and rodent translational modeling, human cardiometabolic disease, as well as human genomics and epidemiology. I have a track record of translational, genomic and biomarker studies in heart and metabolic disease as well as in assembling multidisciplinary teams for execution of translational and genomic research. At this conference, I will present data on the genomics of coronary artery disease and myocardial infarction.

Selected Publications

Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH.: PCSK9 is a critical regulator of the innate immune response and septic shock outcome. Sci Transl Med. 6(258), October 2014

Yoneyama S(1), Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F, Baumert J, Beitelshees A, Berenson GS, Boer JM, Burke G, Cade B, Chen W, Cooper-Dehoff RM, Gaunt TR, Gieger C, Gong Y, Gorski M, Heard-Costa N, Johnson T, Lamonte MJ, McDonough C, Monda KL, Onland-Moret NC, Nelson CP, O'Connell JR, Ordovas J, Peter I, Peters A, Shaffer J, Shen H, Smith E, Speilotes L, Thomas F, Thorand B, Monique Verschuren WM, Anand SS, Dominiczak A, Davidson KW, Hegele RA, Heid I, Hofker MH, Huggins GS, Illig T, Johnson JA, Kirkland S; Look AHEAD Research Group, König W, Langaee TY, McCaffery J, Melander O, Mitchell BD, Munroe P, Murray SS, Papanicolaou G, Redline S, Reilly M, Samani NJ, Schork NJ, Van Der Schouw YT, Shimbo D, Shuldiner AR, Tobin MD, Wijmenga C, Yusuf S; GIANT Consortium; CARe IBC Consortium, Hakonarson H, Lange LA, Demerath EW, Fox CS, North KE, Reiner AP, Keating B, Taylor KC.: Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet. 23(9): 2498-510, May 2014

Wing MR(1), Yang W, Teal V, Navaneethan S, Tao K, Ojo A, Guzman NN, Reilly M, Wolman M, Rosas SE, Cuevas M, Fischer M, Lustigova E, Master SR, Xie D, Appleby D, Joffe M, Kusek J, Feldman HI, Raj DS; Chronic Renal Insufficiency Cohort (CRIC) Study.: Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study. Obesity (Silver Spring). 22(5): 1359-66, May 2014

Ferguson JF, Ryan M, Gibney E, Brennan L, Roche HM, Reilly MP.: Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers Nutr Metab Cardiovasc Dis. 24(9): 996-1003, September 2014.

Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP.: A Functional Synonymous Coding Variant in the IL1RN Gene Associates with Survival in Septic Shock. Am J Respir Crit Care Med.[Epub ahead of print] (656-64), September 2014.

Mehta1 NN, Matthews G, Krishnamoorthy P, Shah R, McLaughlin C, Patel P, Budoff M, Chen J, Wolman M, Go A, He J, Kanetsky PA, Master SM, Rader DJ, Raj D, Gadegbeku CA, Shah R, Schreiber M, Fischer MJ, Townsend RR, Kusek J, Feldman HI, Foulkes AS, Reilly MP, and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.: Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: Findings from the Chronic Renal Insufficiency Cohort Study. Eur Heart J. 35(31): 2115-22, August 2014.

Prenner SB, Mulvey CK, Ferguson JF, Rickels MR, Bhatt AB, Reilly MP.: Very low density lipoprotein cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating levels of triglycerides. Atherosclerosis. 236(2): 244-250, July 2014.

Lim ET(1), Würtz P(2), Havulinna AS(3), Palta P(4), Tukiainen T(5), Rehnström K(6), Esko T(7), Mägi R(8), Inouye M(9), Lappalainen T(10), Chan Y(11), Salem RM(12), Lek M(5), Flannick J(13), Sim X(14), Manning A(15), Ladenvall C(16), Bumpstead S(6), Hämäläinen E(4), Aalto K(17), Maksimow M(17), Salmi M(18), Blankenberg S(19), Ardissino D(20), Shah S(21), Horne B(22), McPherson R(23), Hovingh GK(24), Reilly MP(25), Watkins H(26), Goel A(26), Farrall M(26), Girelli D(27), Reiner AP(28), Stitziel NO(29), Kathiresan S(30), Gabriel S(15), Barrett JC(6), Lehtimäki T(31), Laakso M(32), Groop L(16), Kaprio J(33), Perola M(34), McCarthy MI(35), Boehnke M(14), Altshuler DM(13), Lindgren CM(36), Hirschhorn JN(12), Metspalu A(8), Freimer NB(37), Zeller T(19), Jalkanen S(18), Koskinen S(38), Raitakari O(39), Durbin R(6), MacArthur DG(5), Salomaa V(3), Ripatti S(40), Daly MJ(5), Palotie A(41); Sequencing Initiative Suomi (SISu) Project.: Distribution and medical impact of loss-of-function variants in the Finnish founder population. PLoS Genet. 10(7), July 2014.

Shashaty MG, Kalkan E, Bellamy SL, Reilly JP, Holena DN, Cummins K, Lanken PN, Feldman HI, Reilly MP, Udupa JK, Christie JD.: Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically ill trauma patients. Crit Care Med. 42(7): 1619-28, July 2014.

Mäkinen VP, Civelek M, Meng Q, Zhang B, Zhu J, Levian C, Huan T, Segrè AV, Ghosh S, Vivar J, Nikpay M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, Blakenberg S, O'Donnell CJ, März W, Laaksonen R, Epstein SE, Kathiresan S, Shah SH, Hazen SL, Reilly MP; Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium, Lusis AJ, Samani NJ, Schunkert H, Quertermous T, McPherson R, Yang X, Assimes TL.: Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. PLoS Genet. 10(7): e1004502, July 2014.

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Last updated: 11/25/2014
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