Perelman School of Medicine at the University of Pennsylvania

Penn Institute for Immunology

Drew Weissman

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
522 Johnson Pavilion
Philadelphia, PA 19104-6073
Office: (215) 614-0291
Fax: (215) 349-5111
Education:
B.A., M.A. (Biochemistry/Enzymology)
Brandeis University, 1981.
M.D. Ph.D. (Immunology/Microbiology)
Boston University, 1987.
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Description of Research Expertise

Dr. Weissman's laboratory focuses on the study of RNA and innate immune system biology and the application of these findings to vaccine research and gene therapy. There are three main projects in his laboratory. The first project began through the use of mRNA encoding antigen as a delivery system to load dendritic cells to promote broad immune responses as part of a vaccine. This project has expanded to include basic studies of RNA immunogenicity and translation and the development of applications for gene therapy. The second project develops new HIV envelope immunogens that can induce broad responses and cross-reactive neutralizing antibodies. The third project continues previous studies that identified a protein found on DC, macrophages, and epithelial cells that binds HIV envelope with high affinity. The main focus of this project is testing whether this and related molecules function in vivo to promote HIV genital tract infection.

Selected Publications

Norbert Pardi, Michael J. Hogan, Martin S. Naradikian, Kaela Parkhouse, Derek W. Cain, Letitia Jones, M. Anthony Moody, Hans P. Verkerke, Arpita Myles, David C. Montefiori, Jenna L. Lobby, Kevin O. Saunders, Hua-Xin Liao, Bette T. Korber, Laura L. Sutherland, Richard M. Scearce, Peter T. Hraber, Hiromi Muramatsu, Houping Ni, Daniel A. Balikov, Charles Lee, Barbara L. Mui, Ying K. Tam, Florian Krammer, Katalin Karikó, Laurence C. Eisenlohr, Thomas D. Madden, Michael J. Hope, Mark G. Lewis, Kelly K. Lee, Scott E. Hensley, Michael P. Cancro, Barton F. Haynes and Drew Weissman: Nucleoside-modified mRNA immunization elicits potent T follicular helper cell responses. Journal of Experimental Medicine i, 2018.

Vinnard C, Ravimohan S, Tamuhla N, Pasipanodya J, Srivastava S, Modongo C, Zetola NM, Weissman D, Gumbo T, Bisson GP: Markers of gut dysfunction do not explain low rifampicin bioavailability in HIV-associated TB. J Antimicrob Chemother 72(7): 2020-2027, Jul 2017.

Vinnard C, Ravimohan S, Tamuhla N, Ivaturi V, Pasipanodya J, Srivastava S, Modongo C, Zetola NM, Weissman D, Gumbo T, Bisson GP: Isoniazid clearance is impaired among human immunodeficiency virus/tuberculosis patients with high levels of immune activation. Br j clin pharmacol 83(4): 801-811, Apr 2017.

Pardi N, Secreto AJ, Shan X, Debonera F, Glover J, Yi Y, Muramatsu H, Ni H, Mui BL, Tam YK, Shaheen F, Collman RG, Karikó K, Danet-Desnoyers GA, Madden TD, Hope MJ, Weissman D: Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge. Nature communications 8: 14630, Mar 2017.

Pardi N, Hogan MJ, Pelc RS, Muramatsu H, Andersen H, DeMaso CR, Dowd KA, Sutherland LL, Scearce RM, Parks R, Wagner W, Granados A, Greenhouse J, Walker M, Willis E, Yu J-S, McGee CE, Sempowski GD, Mui BL, Tam YK, Huang Y-J, Vanlandingham D, Holmes VM, Balachandran H, Sahu S, Lifton M, Higgs S, Hensley SE, Madden TD, Hope MJ, Karikó K, Santra S, Graham BS, Lewis MG, Pierson TC, Haynes BF, Weissman D: Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Nature 543(7644): 248-251, Mar 2017.

Ravimohan S, Tamuhla N, Nfanyana K, Ni H, Steenhoff AP, Gross R, Weissman D, Bisson GP: Elevated pre-ART CD39+CD8+ T-cell frequency is associated with early mortality in advanced HIV/TB. Clin Infect Dis 64(10): 1453-1456, Feb 2017.

Pardi N, Weissman D: Measuring the Adjuvant Activity of RNA Vaccines. Methods Mol Bio 1499: 143-153, 2017.

Vinnard C, Ravimohan S, Tamuhla N, Ivaturi V, Pasipanodya J, Kant S, Modongo C, Zetola NM, Weissman D, Gumbo T, Bisson GP: Immune Activation and Isoniazid Metabolism in HIV-associated Tuberculosis. PLOS ONE In Press, 2017.

Norbert Pardi, Michael J. Hogan, Frederick W. Porter and Drew Weissman: mRNA vaccines – opening a new era in vaccinology. Nature Reviews Drug Discovery In Press, 2017.

Pardi N, Weissman D: Nucleoside Modified mRNA Vaccines for Infectious Diseases. Method Mol Bio 1499: 109-121, 2017.

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Last updated: 11/08/2017
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