David Edward Kaplan

faculty photo
Associate Professor of Medicine (Gastroenterology) at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center
Department: Medicine

Contact information
3400 Civic Center Drive, PCAM 7S GI
Philadelphia, PA 19104
Office: 215-349-8222
Fax: 215-349-5915
Lab: 215-823-5800 x 206729
Education:
B.A. (Political Science)
University of California, San Diego, 1992.
M.D. (Medicine)
University of Texas Southwestern Medical School, 1997.
M.Sc. (Patient-Oriented Research)
University of Pennsylvania, 2007.
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Description of Research Expertise

Hepatitis C and hepatocellular carcinoma immunopathogenesis

Description of Clinical Expertise

Hepatology, viral and non-viral chronic liver disease and cirrhosis, hepatocellular carcinoma, end-stage liver disease

Selected Publications

Pazoki R, Vujkovic M, Elliott J, Evangelou E, Gill D, Ghanbari M, van der Most PJ, Pinto RC, Wielscher M, Farlik M, Zuber V, de Knegt RJ, Snieder H, Uitterlinden AG, Lifelines Cohort Study, Lynch JA, Jiang X, Said S, Kaplan DE, Lee KM, Serper M, Carr RM, Tsao PS, Atkinson SR, Dehghan A, Tzoulaki I, Ikram MA, Herzig KH, Jarvelin MR, Alizadeh BZ, O'Donnell CJ, Saleheen D, Voight BF, Chang KM, Thursz MR, Elliott P, VA Million Veteran Program: Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. Nat Comm 12(1): 2579, May 2021.

Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Townsend Creasy K, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; EPoS Consortium; VA Million Veteran Program, Rader DJ, Voight BF, Chang KM: A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Nat Genet 54(5): 761-771, Jun 2022.

Goldberg D, Mantero A, Kaplan D, Delgado C, John B, Nuchovich N, Emanuel E, Reese PP.: Accurate long-term prediction of death for patients with cirrhosis. Hepatology 76(3): 700-711, Sep 2022.

John BV, Deng Y, Scheinberg A, Mahmud N, Taddei TH, Kaplan D, Labrada M, Baracco G, Dahman B. : Association of BNT162b2 mRNA and mRNA-1273 Vaccines With COVID-19 Infection and Hospitalization Among Patients With Cirrhosis. JAMA Intern Med. 181(10): 1306-1314, Oct 2021.

Kaplan DE, Serper M, Mehta R, Fox R, John B, Aytaman A, Baytarian M, Hunt K, Albrecht J, Njei B, Taddei TH; VOCAL Study Group.: Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis. Gastroenterology 156(6): 1693-1706, Jan 2019.

Mahmud N, Chapin S, Goldberg DS, Reddy KR, Taddei TH, Kaplan DE.: Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort. J Hepatology 76(5): 1100-1108, May 2022.

Ioannou George N, Beste Lauren A, Green Pamela K, Singal Amit G, Tapper Elliot B, Waljee Akbar K, Sterling Richard K, Feld Jordan J, Kaplan David E, Taddei Tamar H, Berry Kristin: Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients with Baseline Cirrhosis or High FIB-4 Scores. Gastroenterology 157(5): 1264-1278.e4, Jul 2019.

Doi H, Iyer TK, Carpenter EL, Li H, Chang KM, Vonderheide RH, Kaplan DE.: Dysfunctional B-cell activation in cirrhosis due to hepatitis C infection associated with disappearance of CD27+ B-cell population. Hepatology 55(3): 709-719, March 2012.

Goldberg DS, French B, Forde KA, Groeneveld PW, Bitterman T, Backus L, Halpern SD, Kaplan DE: Association of distance from a transplant center with access to waitlist placement, receipt of liver transplantation, and survival. JAMA 311(12): 1234-43, Mar 2014.

Serper M, Kaplan DE, Shults J, Reese PP, Beste LA, Taddei TH, Werner RM: Quality measures, all-cause mortality, and healthcare utilization in a national cohort of Veterans with cirrhosis. Hepatology 70(6): 2062-2074, Dec 2019.

Cai X, Zhai J, Kaplan DE, Zhang Y, Zhou L, Chen X, Qian G, Zhao Q, Li Y, Gao L, Cong W, Zhu M, Yan Z, Shi L, Wu D, Wei L, Shen F, Wu M : Background Progenitor Activation is Associated with Recurrence after Hepatectomy of Combined Hepatocellular Cholangiocarcinoma. Hepatology 56(5): 1804-16, Jun 2012.

Serper M, Weinberg EM, Cohen JB, Reese PP, Taddei TH, Kaplan DE: Mortality and hepatic decompensation in patients with cirrhosis and atrial fibrillation treated with anticoagulation. Hepatology 73(1): 219-232, Jan 2021.

Mahmud N, Fricker Z, Serper M, Kaplan DE, Rothstein KD, Goldberg DS.: In-Hospital mortality varies by procedure type among cirrhosis surgery admissions. Liver Int 39(8): 1394-1399, Aug 2019.

Emdin Connor A, Haas Mary E, Khera Amit V, Aragam Krishna, Chaffin Mark, Klarin Derek, Hindy George, Jiang Lan, Wei Wei-Qi, Feng Qiping, Karjalainen Juha, Havulinna Aki, Kiiskinen Tuomo, Bick Alexander, Ardissino Diego, Wilson James G, Schunkert Heribert, McPherson Ruth, Watkins Hugh, Elosua Roberto, Bown Matthew J, Samani Nilesh J, Baber Usman, Erdmann Jeanette, Gupta Namrata, Danesh John, Saleheen Danish, Chang Kyong-Mi, Vujkovic Marijana, Voight Ben, Damrauer Scott, Lynch Julie, Kaplan David, Serper Marina, Tsao Philip, Mercader Josep, Hanis Craig, Daly Mark, Denny Joshua, Gabriel Stacey, Kathiresan Sekar: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLoS Genetics 16(4): e1008629, Apr 2020.

Serper M, Choi G, Forde-McLean K, Kaplan DE: Care Delivery and Outcomes among U.S. Veterans with Hepatitis B: A National Cohort Study. Hepatology 63(6): 1774-82, Jun 2016.

Kaplan DE, Dai F, Aytaman A, Baytarian M, Fox R, Hunt K, Knott A, Pedrosa M, Pocha C, Mehta R, Duggal M, Skanderson M, Valderrama A, Taddei T: Development and performance of an algorithm to estimate the Child-Turcotte-Pugh Score from a national electronic healthcare database. Clin Gastroenterol Hepatol 13(13): 2333-41 e1-6, Dec 2015.

Kaplan DE, Sugimoto K, Valiga M, Newton K, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM. : Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132(2): 654-666, February 2007.

Kaplan DE, Sugimoto K, Ikeda F, Stadanlick J, Valiga M, Shetty K, Reddy KR, Chang KM.: T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C. Hepatology 41(6): 1365-75, June 2005.

Sugimoto K, Kaplan DE, Ikeda F, Ding J, Schwartz J, Nunes FA, Alter HJ, Chang KM.: Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection. J Virol 79(11): 6976-83, June 2005.

Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, Nunes FA, Reddy KR, Chang KM.: Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48(6): 903-913, June 2008.

Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM: Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134(7): 1927-37, 1937.e1-2, June 2008.

Xu Y, Li H, Gao RL, Adeyemo O, Itkin M, Kaplan DE.: Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients. Clinical Immunol 139(3): 302-313, June 2011.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R.: Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study. Annals of Internal Medicine 155(6): 353-360, September 2011.

Li Y, Siegel DL, Scholler N, Kaplan DE.: Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library. BMC Biotechnology 12(1): 23, May 2012.

Reddy KR, Belle SH, Fried MW, Afdhal N, Navarro VJ, Hawke RL, Wahed AS, Doo E, Meyers CM; SyNCH Study Group: Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C. Clin Trials 9(1): 102-112, Feb 2012.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R : Adherence to Hepatitis C Virus Therapy in HIV/Hepatitis C-Coinfected Patients. AIDS Behav 17(1): 94-103, Jan 2013.

Adeyemo O, Doi H, Reddy KR, Kaplan DE: Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection. J Viral Hepat 20(7): 453-62, July 2013.

Kluck J, O'Flynn RM, Kaplan DE, Chang KM: Evaluation of the Significance of Pretreatment Liver Biopsy and Baseline Mental Health Disorder Diagnosis on Hepatitis C Treatment Completion Rates at a Veterans Affairs Medical Center. Hepat Res Treat 2013(17): 653976, May 2013.

Doi H, Tanoue S, Kaplan DE: Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis. Clinical Immunol 150(2): 184-191, February 2014.

Darpolor MM, Basu SS, Worth A, Nelson DS, Clarke-Katzenberg RH, Glickson JD, Kaplan DE, Blair IA: Aspartate Metabolism Pathway is Differentiable in Human Hepatocellular Carcinoma: Transcriptomics and 13C-Isotope based Metabolomics. NMR Biomed 27(4): 381-9, Apr 2014.

Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA, Aytaman A, Reddy KR, Chang KM: Distinct Features in Natural History and Outcomes of Acute Hepatitis C. J Clin Gastroenterol 49(4): e31-e40, Apr 2015.

Goldberg DS, Taddei TH, Serper M, Mehta R, Dieperink E, Aytaman A, Baytarian M, Fox R, Hunt K, Pedrosa M, Pocha C, Valderrama A, Kaplan DE: Identifying barriers to hepatocellular carcinoma surveillance in a national sample of patients with cirrhosis. Hepatology 65(3): 864-874, Mar 2017.

Chang LY, Li Y, Kaplan DE: Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis. Scientific Reports 6(18): 36862, Nov 2016.

Mahmud N, Fricker Z, Hubbard RA, Ioannou GN, Lewis JD, Taddei TH, Rothstein KD, Serper M, Goldberg DS, Kaplan DE.: Risk Prediction Models for Post-Operative Mortality in Patients With Cirrhosis. Hepatology 73(1): 204-218, Jan 2021.

Mahmud N, Fricker Z, Lewis JD, Taddei TH, Goldberg DS, Kaplan DE: Risk Prediction Models for Postoperative Decompensation and Infection in Patients With Cirrhosis: A Veterans Affairs Cohort Study. Clin Gastroenterol Hepatol 20(5): e1121-1134, May 2022.

Tischfield DJ, Gurevich A, Johnson O, Gatmaytan I, Nadolski GJ, Soulen MC, Kaplan DE, Furth E, Hunt SJ, Gade TPF: Transarterial Embolization Modulates the Immune Response within Target and Nontarget Hepatocellular Carcinomas in a Rat Model Radiology 303(1): 215-225, Apr 2022.

John BV, Deng Y, Schwartz KB, Taddei TH, Kaplan DE, Martin P, Chao HH, Dahman B.: Postvaccination COVID-19 infection is associated with reduced mortality in patients with cirrhosis. Hepatology 76(1): 126-138, Jul 2022.

Asrani SK, Ghabril MS, Kuo A, Merriman RB, Morgan T, Parikh ND, Ovchinsky N, Kanwal F, Volk ML, Ho C, Serper M, Mehta S, Agopian V, Cabrera R, Chernyak V, El-Serag HB, Heimbach J, Ioannou GN, Kaplan D, Marrero J, Mehta N, Singal A, Salem R, Taddei T, Walling AM, Tapper EB.: Quality measures in HCC care by the Practice Metrics Committee of the American Association for the Study of Liver Diseases. Hepatology 75(5): 1289-1299, May 2022.

Mahmud N, Serper M, Taddei TH, Kaplan DE: The Association Between Proton Pump Inhibitor Exposure and Key Liver-Related Outcomes in Patients With Cirrhosis: A Veterans Affairs Cohort Study Gastroenterology 163(1): 257-269e5, Jul 2022.

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Last updated: 02/28/2024
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