Laura A Johnson

faculty photo
Adjunct Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Smilow Translational Research Center
3400 Civic Center Blvd
University of Pennsylvania
Philadelphia, PA
Education:
BSc (Biological Sciences)
Simon Fraser University, 1998.
MSc (Experimental Pathology)
University of British Columbia, 2000.
PhD (Molecular and Cellular Immunology)
University of British Columbia, 2004.
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Description of Other Expertise

preclinical murine modeling of cancer immunotherapy

Description of Research Expertise

gene-engineered immunotherapy of cancer, Translational research

Selected Publications

Posey AD Jr, Schwab RD, Boesteanu AC, Steentoft C, Mandel U, Engels B, Stone JD, Madsen TD, Schreiber K, Haines KM, Cogdill AP, Chen TJ, Song D, Scholler J, Kranz DM, Feldman MD, Young R, Keith B, Schreiber H, Clausen H, Johnson LA, June CH: Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma. Immunity 44(6): 1444-54, Jun 2016.

Luis Sanchez-Perez, Carter M Suryadevara, Bryan D Choi, Laura A Johnson : CAR Therapy of Brain Tumors. Book chapter in: Translational Immunotherapy of Brain Tumors: an Update in Basic Immunology, Translational Immunotherapy and Clinical Trials. Sampson (eds.). Elsevier, in press 2016.

Laura A Johnson and Carl H. June: Driving gene-engineered T cell immunotherapy of cancer. Cell Research in press 2016 Notes: in press.

Nair Smita K, Driscoll Timothy, Boczkowski David, Schmittling Robert, Reynolds Renee, Johnson Laura A, Grant Gerald, Fuchs Herbert, Bigner Darell D, Sampson John H, Gururangan Sridharan, Mitchell Duane A: Ex vivo generation of dendritic cells from cryopreserved, post-induction chemotherapy, mobilized leukapheresis from pediatric patients with medulloblastoma. Journal of neuro-oncology 125(1): 65-74, Oct 2015.

Johnson Laura A, Scholler John, Ohkuri Takayuki, Kosaka Akemi, Patel Prachi R, McGettigan Shannon E, Nace Arben K, Dentchev Tzvete, Thekkat Pramod, Loew Andreas, Boesteanu Alina C, Cogdill Alexandria P, Chen Taylor, Fraietta Joseph A, Kloss Christopher C, Posey Avery D, Engels Boris, Singh Reshma, Ezell Tucker, Idamakanti Neeraja, Ramones Melissa H, Li Na, Zhou Li, Plesa Gabriela, Seykora John T, Okada Hideho, June Carl H, Brogdon Jennifer L, Maus Marcela V: Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma. Science translational medicine 7(275): 275ra22, Feb 2015.

Johnson Laura A, Sanchez-Perez Luis, Suryadevara Carter M, Sampson John H: Chimeric antigen receptor engineered T cells can eliminate brain tumors and initiate long-term protection against recurrence. Oncoimmunology 3(7): e944059, Nov 2014.

Malecek Karolina, Grigoryan Arsen, Zhong Shi, Gu Wei Jun, Johnson Laura A, Rosenberg Steven A, Cardozo Timothy, Krogsgaard Michelle: Specific increase in potency via structure-based design of a TCR. Journal of immunology (Baltimore, Md. : 1950) 193(5): 2587-99, Sep 2014.

June Carl H, Maus Marcela V, Plesa Gabriela, Johnson Laura A, Zhao Yangbing, Levine Bruce L, Grupp Stephan A, Porter David L: Engineered T cells for cancer therapy. Cancer immunology, immunotherapy : CII 63(9): 969-75, Sep 2014.

Nair Smita K, De Leon Gabriel, Boczkowski David, Schmittling Robert, Xie Weihua, Staats Janet, Liu Rebecca, Johnson Laura A, Weinhold Kent, Archer Gary E, Sampson John H, Mitchell Duane A: Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells. Clinical cancer research : an official journal of the American Association for Cancer Research 20(10): 2684-94, May 2014.

Miao Hongsheng, Choi Bryan D, Suryadevara Carter M, Sanchez-Perez Luis, Yang Shicheng, De Leon Gabriel, Sayour Elias J, McLendon Roger, Herndon James E, Healy Patrick, Archer Gary E, Bigner Darell D, Johnson Laura A, Sampson John H: EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma. PloS one 9(4): e94281, Apr 2014.

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Last updated: 03/09/2017
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