Penn Lung Center

Faculty & Staff

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Melpo Christofidou-Solomidou, PhD

Research Associate Professor of Medicine
Director, Pulmonary Morphology Core Laboratory, University of Pennsylvania School of Medicine, Philadelphia, PA
Research Associate Professor of Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine
Investigator, Center for Excellence in Environmental Toxicology (CEET), University of Pennsylvania
Investigator, Abramson Cancer Center, University of Pennsylvania
Adjunct Faculty, Institute for Environmental Medicine (IFEM), University of Pennsylvania
Department: Medicine

Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3615 Civic Center Boulevard
Abramson Research Center, Office Suite 1016C
Philadelphia, PA 19104-6160
Office: (215) 573-9917
Fax: (215) 573-4469
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Post-Graduate Training
Postdoctoral Fellow, Department of Physiology & Cell Biology, Albany Medical College, Albany, NY, 1991-1992.
Postdoctoral Fellow, New York State Affiliate of the American Heart Association, Albany Medical College, Albany, NY, 1992-1993.
Postdoctoral Fellow, Department of Dermatology and Pulmonary, Allergy & Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, 1993-1995.
Postdoctoral Fellow, Pulmonary, Allergy & Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, 1995-1996.
Patient Oriented Research Certification-University of Pennsylvania, 2007.
Permanent link
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Description of Research Expertise

The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.

Selected Publications

Christofidou-Solomidou Melpo, Pietrofesa Ralph A, Arguiri Evguenia, Schweitzer Kelly S, Berdyshev Evgeny V, McCarthy Maureen, Corbitt Astrid, Alwood Joshua S, Yu Yongjia, Globus Ruth K, Solomides Charalambos C, Ullrich Robert L, Petrache Irina: Space radiation-associated lung injury in a murine model. American journal of physiology. Lung cellular and molecular physiology 308(5): L416-28, Mar 2015.

Clementina Mesaros, Andrew J. Worth, Nathaniel W. Snyder, Christofidou-Solomidou, M, Anil Vachani, Steven M. Albelda, and Ian A. Blair: Biomarkers of response to human asbestos exposure (Review). Bioanalysis In Press, 2015.

Christofidou-Solomidou Melpo, Pietrofesa Ralph, Arguiri Evguenia, McAlexander Melissa A, Witwer Kenneth W: Dietary flaxseed modulates the miRNA profile in irradiated and non-irradiated murine lungs: a novel mechanism of tissue radioprotection by flaxseed. Cancer biology & therapy 15(7): 930-7, Jul 2014.

Chowdhury Ibrul, Fisher Aron B, Christofidou-Solomidou Melpo, Gao Ling, Tao Jain-Qin, Sorokina Elena M, Lien Yu-Chin, Bates Sandra R, Feinstein Sheldon I: Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic. Antioxidants & redox signaling 20(3): 391-402, Jan 2014.

Akay Cagla, Cooper Michael, Odeleye Akinleye, Jensen Brigid K, White Michael G, Vassoler Fair, Gannon Patrick J, Mankowski Joseph, Dorsey Jamie L, Buch Alison M, Cross Stephanie A, Cook Denise R, Peña Michelle-Marie, Andersen Emily S, Christofidou-Solomidou Melpo, Lindl Kathryn A, Zink M Christine, Clements Janice, Pierce R Christopher, Kolson Dennis L, Jordan-Sciutto Kelly L: Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system. Journal of neurovirology Jan 2014.

Pietrofesa Ralph A, Solomides Charalambos C, Christofidou-Solomidou Melpo: Flaxseed Mitigates Acute Oxidative Lung Damage in a Mouse Model of Repeated Radiation and Hyperoxia Exposure Associated with Space Exploration. Journal of pulmonary & respiratory medicine 4(6), 2014.

Pietrofesa, RA, Solomides, CC and Christofidou-Solomidou, M: Flaxseed mitigates acute oxidative lung damage in a mouse model of repeated radiation and hyperoxia exposure associated with space exploration. Journal of Pulmonary & Respiratory Medicine 2014.

Mishra Om P, Simmons Nicholas, Tyagi Sonia, Pietrofesa Ralph, Shuvaev Vladimir V, Valiulin Roman A, Heretsch Philipp, Nicolaou K C, Christofidou-Solomidou Melpo: Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorganic & medicinal chemistry letters 23(19): 5325-8, Oct 2013.

Pietrofesa Ralph A, Turowski Jason B, Arguiri Evguenia, Milovanova Tatyana N, Solomides Charalambos C, Thom Stephen R, Christofidou-Solomidou Melpo: Oxidative Lung Damage Resulting from Repeated Exposure to Radiation and Hyperoxia Associated with Space Exploration. Journal of pulmonary & respiratory medicine 3(5), Sep 2013.

Tan Qiulin, Kerestes Heddy, Percy Melanie J, Pietrofesa Ralph, Chen Li, Khurana Tejvir S, Christofidou-Solomidou Melpo, Lappin Terence R J, Lee Frank S: Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation. The Journal of biological chemistry 288(24): 17134-44, Jun 2013.

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Last updated: 03/16/2015
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