Paul F. Harron Jr. Lung Center

Paul F. Harron Jr. Lung Center Faculty

faculty photo

Melpo Christofidou-Solomidou, PhD

Research Associate Professor of Medicine
Director, Pulmonary Morphology Core Laboratory, University of Pennsylvania School of Medicine, Philadelphia, PA
Research Associate Professor of Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine
Investigator, Center for Excellence in Environmental Toxicology (CEET), University of Pennsylvania
Investigator, Abramson Cancer Center, University of Pennsylvania
Adjunct Faculty, Institute for Environmental Medicine (IFEM), University of Pennsylvania
Founder and Chair of the Scientific Advisory Board, LignaMed, LLC, an Upstart company in collaboration with the Penn Center for Innovation (PCI) of the University of Pennsylvania
Department: Medicine

Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3615 Civic Center Boulevard
Abramson Research Center, Office Suite 1016C
Philadelphia, PA 19104-6160
Office: (215) 573-9917
Fax: (215) 573-4469
Education:
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Post-Graduate Training
Postdoctoral Fellow, Department of Physiology & Cell Biology, Albany Medical College, Albany, NY, 1991-1992.
Postdoctoral Fellow, New York State Affiliate of the American Heart Association, Albany Medical College, Albany, NY, 1992-1993.
Postdoctoral Fellow, Department of Dermatology and Pulmonary, Allergy & Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, 1993-1995.
Postdoctoral Fellow, Pulmonary, Allergy & Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, 1995-1996.
Certifications
Patient Oriented Research Certification-University of Pennsylvania, 2007.
Permanent link
 
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Description of Research Expertise

The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.

Selected Publications

Pietrofesa R, Menges CW, Testa JR, Albelda SM, and Christofidou-Solomidou M. : Flaxseed lignans enriched in Secoisolariciresinol Diglucoside (SDG) inhibit asbestos-induced peritoneal inflammation in mice. Superfund Research Program (SRP) Annual Meeting. San Juan, Puerto Rico. November 2015.

Erickson M, King J, Odeleye A, Seto K, Pietrofesa R, Winkelstein B, Akay Espinoza C, Christofidou-Solomidou M, and Jordan-Sciutto K. : Protective effects of Secoisolariciresinol Diglucoside against oxidant stress, neuroinflammation, and HIV neurotoxicity. Society for Neuroscience, Neuroscience Annual Meeting. Chicago, IL. October 2015 Notes: Poster Presentation.

Pietrofesa R, Menges CW, Testa JR, Albelda SM, and Christofidou-Solomidou M. : Flaxseed and its lignan component protect from asbestos-induced inflammation in mice. American Association for Cancer Research (AACR) Annual Meeting. Philadelphia, PA. April 2015 Notes: Poster Presentation.

Christofidou-Solomidou Melpo, Pietrofesa Ralph A, Arguiri Evguenia, Schweitzer Kelly S, Berdyshev Evgeny V, McCarthy Maureen, Corbitt Astrid, Alwood Joshua S, Yu Yongjia, Globus Ruth K, Solomides Charalambos C, Ullrich Robert L, Petrache Irina: Space radiation-associated lung injury in a murine model. American journal of physiology. Lung cellular and molecular physiology 308(5): L416-28, Mar 2015.

Clementina Mesaros, Andrew J. Worth, Nathaniel W. Snyder, Christofidou-Solomidou, M, Anil Vachani, Steven M. Albelda, and Ian A. Blair: Biomarkers of response to human asbestos exposure (Review). Bioanalysis In Press, 2015.

Clementina Mesaros, Andrew J. Worth, Nathaniel W. Snyder, Christofidou-Solomidou, M, Anil Vachani, Steven M. Albelda, and Ian A. Blair: Biomarkers of response to human asbestos exposure (Review). In Press, Bioanalysis 2015.

Turowski JB, Pietrofesa RA, Lawson JA, Christofidou-Solomidou, M and Hadjiliadis D: Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study. BMC Complementary and Alternative Medicine 2015.

Clementina Mesaros, Andrew J. Worth, Nathaniel W. Snyder, Christofidou-Solomidou, M, Anil Vachani, Steven M. Albelda, and Ian A. Blair: Biomarkers of response to human asbestos exposure. Bioanalysis 2015.

Mishra OP, Pietrofesa R, Christofidou-Solomidou M. : Novel synthetic (S,S) and (R,R)-Secoisolariciresinol Diglucosides (SDGs) protect naked plasmid and genomic DNA from gamma radiation damage. Superfund Research Program (SRP) Annual Meeting. San Jose, CA. November 2014 Notes: Poster Presentation.

Christofidou-Solomidou Melpo, Pietrofesa Ralph, Arguiri Evguenia, McAlexander Melissa A, Witwer Kenneth W: Dietary flaxseed modulates the miRNA profile in irradiated and non-irradiated murine lungs: a novel mechanism of tissue radioprotection by flaxseed. Cancer biology & therapy 15(7): 930-7, Jul 2014.

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Last updated: 05/19/2015
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