Penn Lung Center

Faculty & Staff

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Mark E. Mikkelsen, MD, MSCE

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Director, Medical Intensive Care Unit Medical Student Externship, Perelman School of Medicine, University of Pennsylvania, Co-Director, 2012-2013
Associate Director, Medical Intensive Care Unit, Hospital of the University of Pennsylvania
Associate Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine of the University of Pennsylvania
Department: Medicine

Contact information
Gates 05042
3400 Spruce Street
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: (215) 615-5416
Fax: (215) 614-0869
Lab: (267) 285-6602
Education:
BA (Political Science)
Colgate University, Hamilton, NY, 1996.
(Post-Baccalaureate Pre-Medical Degree Program)
Bryn Mawr College, Bryn Mawr, PA, 1997.
MD (Medical Degree)
University of Virginia School of Medicine, Charlottesville, VA, 2002.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, Philadelphia, PA, 2008.
Post-Graduate Training
Internship, Internal Medicine, Hospital of the University of Pennsylvania, 2002-2003.
Residency, Internal Medicine, Hospital of the University of Pennsylvania, 2003-2005.
Post-Doctoral Fellow, Pulmonary, Allergy and Critical Care Division, Hospital of the University of Pennsylvania, 2005-2008.
Certifications
American Board of Internal Medicine, Internal Medicine , 2005.
American Board of Internal Medicine, Pulmonary Disease, 2008.
American Board of Internal Medicine, Critical Care Medicine, 2009.
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Description of Research Expertise

Dr. Mikkelsen's research aims to improve the outcomes of critically ill patients through patient-oriented research focused on sepsis, acute lung injury, and long-term outcomes in survivors of critical illness. He is passionate in his goal to improve the delivery of care to critically ill patients and to improve the lives of survivors of critical illness.


Sepsis
Acute Lung Injury
Long-Term Outcomes of Critical Illness
Neuropsychological Impairment in Survivors of Critical Illness

Description of Clinical Expertise

Dr. Mikkelsen's philosophy for patient care is to ensure that exceptional, compassionate care is delivered to critically ill patients and their family members through outstanding, multi-disciplinary teamwork across the continuum of care, through the application of evidence-based care, and through systematic study to optimize our performance.

Sepsis
Acute Lung Injury
Rescue Therapies for Acute Lung Injury
Long-Term Neuropsychological Outcomes in Survivors of Critical Illness
Long-Term Neuropsychological Outcomes in Family Members of Critically Ill Patients

Selected Publications

Mikkelsen ME, Netzer G, Iwashyna TJ: Post-intensive care syndrome (PICS) and post-intensive care syndrome - family (PICS-F). UpToDate. Basow, DS (eds.). UpToDate, Waltham, MA 2014.

Maley JH, Mikkelsen ME: Sepsis survivorship: how can we promote a culture of resilience? Crit Care Med 2014 Notes: Editorial; in press.

Gaieski DF, Edwards JM, Kallan MJ, Mikkelsen ME, Goyal M, Carr BG : The relationship between hospital volume and mortality in severe sepsis. Am J Respir Crit Care Med 2014 Notes: In press.

Mark E. Mikkelsen and Horace DeLisser : Family centered care and communication with families of intensive care unit patients. The Intensive Care Unit Manual. 2nd Edition. Paul N. Lanken, MD (eds.). W.B. Saunders Company, 2014 Notes: Chapter.

Mikkelsen ME, Anderson B, Christie JD, Hopkins RO, Lanken PN: Can we optimize long-term outcomes in acute respiratory distress syndrome by targeting normoxemia? Ann Amer Thor Soc 11(4): 613-618, 2014.

Cohen DG, Christie JD, Anderson BJ, Diamond JM, Judy RP, Shah RJ, Cantu E, Bellamy SL, Bumenthal N, Demissie E, Hopkins RO, Mikkelsen ME: Cognitive function after lung transplantation. Am J Respir Crit Care Med 2014 Notes: Poster presentation

Meyer NJ, Shashaty MGS, Kazi A, Hudock KM, Herlim M, Charles D, Oz NL, Dunn TG, Rushefski M, Reilly JP, Shah CV, Christie JD, Mikkelsen ME: Human neutropenic sepsis is characterized by increased early shock, increased mortality, and increased inflammatory cytokine response Am J Respir Crit Care Med 2014 Notes: Oral poster presentation.

Jones TK, Fuchs BD, Small DS, Halpern SD, Hanish A, Baillie C, Umscheid CA, Kerlin MP, Gaieski DF, Mikkelsen ME: Severe sepsis is associated with high rates of hospital readmission. Am J Respir Crit Care Med 2014 Notes: Oral presentation.

Anderson BJ, Cohen DG, Christie JD, Judy R, Diamond J, Shah RJ, Cantu E, Bellamy SL, Hopkins RO, Mikkelsen ME : Psychological distress, resilience, and quality of life after lung transplantation. Am J Respir Crit Care Med 2014 Notes: Poster presentation.

Leary M, Cinousis M, Mikkelsen ME, Gaieski DF, Abella BS, Fuchs BD: The association of body mass index with time to target temperature and outcomes following post-arrest targeted temperature management. Resusc 85(2): 244-247, 2014.

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Last updated: 09/10/2014
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