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Mark E. Mikkelsen, MD, MSCE

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Associate Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine of the University of Pennsylvania
Chief, Section of Medical Critical Care, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Health System
Department: Medicine

Contact information
Gates 05042
3400 Spruce Street
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: (215) 615-5416
Fax: (215) 614-0869
Lab: (267) 285-6602
BA (Political Science)
Colgate University, Hamilton, NY, 1996.
(Post-Baccalaureate Pre-Medical Degree Program)
Bryn Mawr College, Bryn Mawr, PA, 1997.
MD (Medical Degree)
University of Virginia School of Medicine, Charlottesville, VA, 2002.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, Philadelphia, PA, 2008.
Post-Graduate Training
Internship, Internal Medicine, Hospital of the University of Pennsylvania, 2002-2003.
Residency, Internal Medicine, Hospital of the University of Pennsylvania, 2003-2005.
Post-Doctoral Fellow, Pulmonary, Allergy and Critical Care Division, Hospital of the University of Pennsylvania, 2005-2008.
LeadingSuccess Program, Office of Organization Effectiveness, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, 2015-2016.
American Board of Internal Medicine, Internal Medicine , 2005.
American Board of Internal Medicine, Pulmonary Disease, 2008.
American Board of Internal Medicine, Critical Care Medicine, 2009.
American Board of Internal Medicine, Internal Medicine Maintenance of Certification, 2015.
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Description of Research Expertise

Through the lens of the patient and their family, Dr. Mikkelsen conducts patient-oriented research focused on sepsis, acute respiratory distress syndrome, and long-term outcomes in survivors of critical illness. He is passionate in his goal to improve the delivery of care to critically ill patients and to improve the lives of survivors of critical illness by understanding how critical illness impacts one's life and one's health trajectory.

Dr. Mikkelsen encourages colleagues, as well as survivors of critical illness and their loved ones, who are committed to improving the quality of care delivered to critically ill patients to contact him at Together, we can "be the difference."

Health services research
Quality Improvement/Implementation and Dissemination Research
Critical Care Delivery
Long-Term Outcomes of Critical Illness

Description of Clinical Expertise

Dr. Mikkelsen's philosophy for patient care is to ensure that exceptional, compassionate care is delivered to critically ill patients and their family members through outstanding, multi-disciplinary teamwork across the continuum of care, through the application of evidence-based care, and through systematic study to optimize our performance. Dr. Mikkelsen is an expert in critical care medicine, and the devastating syndromes of sepsis, acute respiratory distress syndrome, and post-intensive care syndrome specifically.

Critical Care Delivery
Quality Improvement
Post-Intensive Care Syndrome
Long-Term Outcomes of Critical Illness

Selected Publications

Anderson BJ, Mikkelsen ME: The road to recovery: turning the tide on losses incurred after critical illness. Crit Care Med 44(11): 2111-2112, Nov 2016 Notes: Editorial.

Price D, Mikkelsen ME, Umscheid CA, Armstrong E: Neuromuscular blocking agents and neuromuscular dysfunction acquired in critical illness: a systematic review and meta-analysis. Crit Care Med 44(11): 2070-2078, Nov 2016.

Gutsche JT, Mikkelsen ME, McCarthy FH, Miano TM, Vernick WJ, Ramakrishna H, Patel PA, Augoustides Y, Szeto WY, Desai ND, Lane-Fall MB, Williams ML: Veno-venous extracorporeal life support in hemodynamically unstable patients with ARDS. Anesth Analg Page: [epub ahead of print] Oct 2016.

Weissman GE, Harhay MO, Lugo RM, Fuchs BD, Halpern SD, Mikkelsen ME: Natural language processing to assess documentation of features of critical illness in discharge documents of ARDS survivors. Ann Am Thorac Soc 13(9): 1538-1545, Sep 2016.

Perman SM, Stanton E, Soar J, Berg R, Donnino M, Mikkelsen ME, Edelson D, Churpek MM, Yang L, Merchant RM : Location of in-hospital cardiac arrest in the US – variability in event rate and outcomes J Amer Heart Assoc 29(5): pii e003638, Sep 2016.

Reilly JP, Anderson BJ, Hudock KM, Dunn TG, Kazi A, Tommasini A, Charles D, Shashaty MGS, Mikkelsen ME, Christie JD, Meyer NJ: Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis. Critical Care 20(1): 222, Jul 2016.

Johnson N, Dodampahala K, Rosselot R, Perman S, Mikkelsen ME, Goyal M, Gaieski DF, Grossestreuer AV : The association between arterial oxygen tension and neurological outcome after cardiac arrest. Ther Hypothermia Temp Manag Page: [epub ahead of print] Jul 2016.

Anderson BJ, Reilly JP, Shashaty MGS, Palakshappa J, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, Kolson DL, Christie JD, Meyer NJ: Admission plasma levels of the neuronal injury marker neuron specific enolase are associated with mortality and delirium in sepsis J Crit Care 23(36): 18-23, Jun 2016.

Mikkelsen ME, Fuchs BD, Grippi MA: Organization of intensive care units and long term acute care hospitals (LTACHs). Fishman's Pulmonary Diseases and Disorders, 5th ed. Grippi M, Elias J, Fishman J, Kotloff R, Pack A, Senior R, eds. (eds.). New York: McGraw-Hill, 152: 2320-2327, April 2016 Notes: Chapter.

Fogarty C, Mikkelsen ME, Shi P, Small DS: Randomization inference and sensitivity analysis for composite null hypotheses with binary outcomes in matched observational studies. J Am Stat Assoc Page: published on-line, Feb 2016.

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Last updated: 12/01/2016
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