Penn Medicine
Help | Search | Site Map | Contact   
faculty photo

Mark E. Mikkelsen, MD, MSCE, FCCM

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Associate Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine of the University of Pennsylvania
Chief, Section of Medical Critical Care, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Health System
Director, Medical Intensive Care Unit, Penn Presbyterian Medical Center
Department: Medicine

Contact information
Gates 05042
3400 Spruce Street
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: (215) 615-5416
Fax: (215) 614-0869
Lab: (267) 285-6602
BA (Political Science)
Colgate University, Hamilton, NY, 1996.
(Post-Baccalaureate Pre-Medical Degree Program)
Bryn Mawr College, Bryn Mawr, PA, 1997.
MD (Medical Degree)
University of Virginia School of Medicine, Charlottesville, VA, 2002.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, Philadelphia, PA, 2008.
Post-Graduate Training
Internship, Internal Medicine, Hospital of the University of Pennsylvania, 2002-2003.
Residency, Internal Medicine, Hospital of the University of Pennsylvania, 2003-2005.
Post-Doctoral Fellow, Pulmonary, Allergy and Critical Care Division, Hospital of the University of Pennsylvania, 2005-2008.
LeadingSuccess Program, Office of Organization Effectiveness, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, 2015-2016.
American Board of Internal Medicine, Internal Medicine , 2005.
American Board of Internal Medicine, Pulmonary Disease, 2008.
American Board of Internal Medicine, Critical Care Medicine, 2009.
American Board of Internal Medicine, Internal Medicine Maintenance of Certification, 2015.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Dr. Mikkelsen is the Chief of the Section of Medical Critical Care at Penn. He serves as Co-Chair of the UPHS Critical Care Committee and Medical Director of the Penn Presbyterian Medical Intensive Care Unit. Through these efforts, he supports the growth and development of a phenomenal group of multidisciplinary Penn providers who are collectively driven to educate the next generation of critical care clinicians, to deliver care of the highest quality to the critically ill, and to create and implement innovative science that advances the field of critical care medicine.

Research Program:
Through the lens of the patient and their family, Dr. Mikkelsen conducts patient-oriented research focused on sepsis, acute respiratory distress syndrome, and long-term outcomes in survivors of critical illness. He is passionate in his goal to improve the delivery of care to critically ill patients and to improve the lives of survivors of critical illness by understanding how critical illness impacts one's life and one's health trajectory.

Dr. Mikkelsen encourages colleagues, as well as survivors of critical illness and their loved ones, who are committed to improving the quality of care delivered to critically ill patients to contact him at Together, we can "be the difference."

Description of Clinical Expertise

Dr. Mikkelsen's philosophy for patient care is to ensure that exceptional, compassionate care is delivered to critically ill patients and their family members through outstanding, multi-disciplinary teamwork across the continuum of care, through the application of evidence-based care, and through systematic study to optimize our performance. Dr. Mikkelsen is an expert in critical care medicine, and the devastating syndromes of sepsis, acute respiratory distress syndrome, and post-intensive care syndrome specifically.

Dr. Mikkelsen serves as Co-Chair of the Society of Critical Care Medicine's Thrive: Supporting Survivors of Critical Illness Initiative, Chair of the SCCM Internal Medicine Section, and is Co-Chair of the 2018 SCCM Congress in San Antonio, Texas. He also serves on the American Thoracic Society's Quality Improvement and Implementation Committee.

Selected Publications

Mikkelsen ME: Triangulating weakness, morbidity, and mortality amongst ARDS survivors: a story emerges. Crit Care Med 45(2): 370-371, Feb 2017 Notes: Editorial.

Anderson BJ, Mikkelsen ME: Bringing the ABCDEF bundle to life and saving lives through the process. Crit Care Med 45(2): 363-365, Feb 2017 Notes: Editorial.

Bhardwaj A, Mikkelsen ME: Sepsis quality improvement initiatives: prepare for the marathon, not the sprint Crit Care Med 45(2): 374-375, Feb 2017 Notes: Editorial.

Mikkelsen ME, Iwashyna TJ: Persistent problems and recovery after critical illness. Oxford Textbook of Medicine 6th Edition. Simon Finfer (eds.). 2017 Notes: Chapter. In press.

Maley JH, Mikkelsen ME: Post-intensive care syndrome Evidence Based Critical Care: A Case Based Approach. Robert Hyzy (eds.). Springer Science, 2017 Notes: Chapter. In press.

Anderson BJ, Mikkelsen ME: Stressing the brain: the immune system, hypothalamic-pituitary-adrenal axis, and psychiatric symptoms in ARDS survivors Ann Am Thorac Soc 2017 Notes: In press.

Gaieski DF, Agarwal AK, Mikkelsen ME, Drumheller B, Cham Sante S, Shofer FS, Goyal M, Pines JM: The impact of emergency department crowding on early interventions and mortality in patients with severe sepsis. Am J Emerg Med 2017 Notes: Epub ahead of print.

Anderson BJ, Mikkelsen ME: Organ dysfunction in sepsis: brain, neuromuscular, cardiovascular, & gastrointestinal. Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management. Ward NS, Levy MM (eds.). Springer Scientific Publications, 2017 Notes: Chapter. In press.

Mikkelsen ME, Andrews A, Iwashyna TJ, Thompson C: Thrive: accomplishments, challenges, and next steps. Critical Connections Online, 2017 Notes: In press.

Semler M, Mikkelsen ME: If at first you don’t succeed: patient characteristics associated with first-attempt failure during video laryngoscopy in the ICU. Ann Am Thor Soc 2017 Notes: Editorial; in press.

back to top
Last updated: 03/23/2017
The Trustees of the University of Pennsylvania
© The Trustees of the University of Pennsylvania. Site best viewed with Mozilla, NN, IE, or Safari.
SOM Home International Programs Penn Alumni Clinical Trials Centers and Institutes Departments Faculty Research Education Administration