Penn Lung Center

Faculty & Staff

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Vera P. Krymskaya, Ph.D., M.B.A., F.C.P.P.

Associate Professor of Medicine
Member, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
Member, Center for Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA
Member, Pulmonary Vascular Disease Program, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA
Member, LAM Clinic, University of Pennsylvania
Member, CVI Pulmonary Vascular Disease Program
Director of Education, Airways Biology Initiative, University of Pennsylvania
Member, Institute for Translational Medicine and Therapeutics
Member, Penn Center for Orphan Disease Research and Therapy
Department: Medicine

Contact information
Translational Research Laboratories
Suite 1200, Room 1213
125 South 31st Street
Philadelphia, PA 19104-3403
Office: (215) 573-9861
Fax: (215) 746-1224
Lab: (215) 746-3599
Graduate Group Affiliations
Education:
BA (Piano)
Ternopol College of Music, Ukraine, 1980.
MBA (Marketing Management)
Plekhanov Institute of Economics, Moscow, USSR, 1986.
PhD (Biology/Radiation Biology)
Department of Biophysics, Moscow State University, Moscow, USSR, 1991.
Post-Graduate Training
Graduate Student, Laboratory of Molecular Radiology, Institute of Biophysics, USSR Academy of Sciences, 1987-1990.
Postdoctoral Researcher, Laboratory of Radiation Biochemistry and Cellular Regulation, Institute of Cell Biophysics, Russian Academy of Sciences, 1991-1992.
Postdoctoral Researcher, Laboratory of Molecular Endocrinology , Institute of Experimental Cardiology, Cardiology Research Center, Russian Academy of Medical Sciences, 1992-1996.
NIH/NHLBI Visiting Scholar, Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, 1995-1995.
Postdoctoral Researcher, Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania, 1996-1996.
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Description of Research Expertise

Signal transduction, tumor suppressor genes TSC1 and TSC2, protein translational regulation, mTOR, ribosomal protein S6, phosphatidylinositol 3-kinase, Akt; lymphangioleiomyomatosis, tuberous sclerosis complex, cancer;
airway cell biology,
vascular cell biology, cell growth, cell proliferation, cell migration,

Description of Clinical Expertise

Not applicable

Description of Other Expertise

Marketing management, concert piano

Selected Publications

Elena A. Goncharova, Dmitry A. Goncharov, Melane Fehrenbach, Irene Khavin, Blerina Ducka, Okio Hino, Thomas V. Colby, Mervyn J. Merrilees, Angela Haczku, Steven M. Albelda, and Vera P. Krymskaya: Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM). Science Translational Medicine 4(154): 154ra134, October 2012 Notes: cited by F1000Prime.

Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP: mTORC2 is required for proliferation and survival of TSC2-null cells Molecular and Cellular Biology 31: 2484-2498, March 2011.

Lyn Moir, Judith Black, and Vera P. Krymskaya: TSC2 modulates cell adhesion and migration via integrin α1β1. American Journal of Physiology - Lung Cellular and Molecular Physiology 303: L703-L710, October 2012.

Elena A Goncharova, Irene S Khavin, Dmitry A Goncharov and Vera P Krymskaya: Differential Effects of Formoterol on Thrombin- and PDGF-Induced Proliferation of Human Pulmonary Arterial Vascular Smooth Muscle Cells Respiratory Research 1186/1465-9921-13-109, Nov 27 2012.

Moir LM, Hy Ng, Poniris MH, Santa T, Burgess JK, Oliver BGG, Krymskaya VP, Black JL: Doxycycline inhibits matrix metalloproteinase-2 secretion from TSC2-null mouse embryonic fibroblasts and lymphangioleiomyomatosis (LAM) cells. British Journal of Pharmacology 164(1): 83-92, Sept 2011.

Gautam Damera, Kirk M. Druey, Philip R. Cooper, Vera P. Krymskaya, Roy J. Soberman, Yassine Amrani, Toshinori Hoshi, Christopher E. Brightling, Reynold A. Panettieri, Jr.: An RGS4-Mediated Phenotypic Switch of Bronchial Smooth Muscle Cells Promotes Fixed Airway Obstruction in Asthma. PLoS One 7(1): e28504, January 2012.

Vera P Krymskaya, Jennifer Snow, Gregory Cesarone, Irene Khavin, Dmitry Goncharov, Poay Lim, Sigrid Veasey, Kaori Ihida-Stanbury, Peter Jones, Elena Goncharova: mTOR is Required for Pulmonary Arterial Vascular Smooth Muscle Cell Proliferation Under Chronic Hypoxia The FASEB Journal 25(6): 1922-1933, June 2011.

Doug A. Medvetz, Damir Khabibullin, Venkatesh Hariharan, Pat P. Ongusaha, Elena A. Goncharova, Tanja Schlechter,Thomas N. Darling, Ilse Hofmann, Vera P. Krymskaya, James K. Liao, Hayden Huang, Elizabeth P. Henske: Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion. PLoS One 7(11): e47842, November 2012.

Koziol-White C., Goncharova E., Cao G., Johnson, M., Krymskaya V. P., Panettieri R.A.: DHEA-S inhibits human neutrophil and airway smooth muscle migration. BBA - Molecular Basis of Disease 1822: 1638-1642, October 2012.

Elena A. Goncharova, Dmitry A. Goncharov, Hengjiang Zhao, Raymond Penn, Richard Knowles, Vera P. Krymskaya, and Reynold A. Panettieri, Jr.: β2-Adrenergic Receptor Agonists Modulate Human Airway Smooth Muscle Cell Migration Via Vasodilator Stimulated Phophoprotein. Amer J Respir Cell Mol Biol 46(1): 48-54, January 2012.

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Last updated: 07/28/2014
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