Lingshu Yin
Lingshu Yin, Ph.D.
Adjunct Assistant Professor of Radiation Oncology
Department: Radiation Oncology
Contact information
TRC-4 West Radiation Oncology
3400 Civic Center Blvd
Philadelphia,, PA 19104
3400 Civic Center Blvd
Philadelphia,, PA 19104
Education:
B.Sc., (Physics)
Nanjing University, Nanjing, China, 2006.
Ph.D. (Medical Physics )
University of British Columbia, 2011.
Permanent linkB.Sc., (Physics)
Nanjing University, Nanjing, China, 2006.
Ph.D. (Medical Physics )
University of British Columbia, 2011.
Description of Clinical Expertise
Machine Quality Assurance• Performed daily, monthly and annual QA for Varian Clinac 2300iX, Truebeam with OBI/CBCT/Calypso and Siemens Oncor machines
Treatment Planning
• Extensive treatment planning experience with Varian Eclipse system
o 3D-CRT, IMRT and RapidArc: CNS, GI/GU, Lung, GYN, Breast, Lymphoma, Sarcoma, Head and Neck
o Special treatment planning including electrons and TBI
Patient Treatment Quality Assurance
• Extensive experience with IMRT and RapidArc patient specific QA using MapCheck2 and ArcCheck
Cyberknife Robotic Radiosurgery System
• Performed daily, monthly and annual QA for Accuray Cyberknife VSI system
Brachytherapy Treatment
• Experience with Varian BrachyVision using Ir-192, performed monthly QA and source exchange calibration of the HDR unit
o Treatment planning and delivery of GYN cases with tandem and ovoid, vaginal cylinders, syed and capri applicators
General Clinical Practice and Projects
• Initial chart checking under the supervision of staff physicists
• On call physicist for after hour emergency treatments and machines issues
• Commissioning of RadCalc (Sun Nuclear) for secondary MU check of 3D-CRT, IMRT and RapidArc
• Commissioning of RapidArc (machine testing, treatment planning and patient specific QA) at the Pennsylvania Hospital
• Monthly QA for Siemens CT (Somatom Definition AS)
• Extensive experience with Varian Aria for paperless charting and R&V
• in vivo dosimetry measurements for Total Body Irradiation treatments using OneDose MOSFET and microStar OSLD
CLINICAL EXPERIENCE – PROTON THERAPY
Acceptance and Commissioning of Cone Beam CT system for proton gantry machine
• Collaboration with IBA on acceptance and commissioning of the first proton therapy specific cone beam CT solution.
• Developing new tools and concepts for image guided proton therapy (IGPT) with CBCT using IBA imageX platform
Acceptance and Commissioning of adaPTinsightTM
• Collaboration with IBA on testing and feedback of this image guidance software platform
• Acceptance and commissioning as the first site implementing this platform
Proton Therapy Machine Quality Assurance
• Daily, monthly, annual machine QA for double scattering, uniform scanning and pencil beam scanning rooms
o Beam quality test (range, modulation and output) tests and absolute dose calibration with IBA Bluephantom and Zebra
o Absolute dose calibration (TRS 398) for pencil beam scanning proton therapy and spot pattern QA with Lynx scintillation detector
Proton Therapy Patient Specific Quality Assurance
• Double scattering patient QA: output and range/modulation measurement using IBA Bluephantom and MatrixX
• Uniform scanning and pencil beam scanning patient QA using IBA Zebra and MatrixX
Daily physics duties
• Provides support for dosimetry on treatment planning
• Initial, weekly chart checks and ends of treatment check
• Provides physics support for therapists during the 1st and 2nd shift
Description of Research Expertise
RESEARCH EXPERIENCE / PROJECTS• Applications for image guided proton therapy with CBCT
Hounsfield units matching for proton CBCT to simulation CT with deformable image registration
Water equivalent plot and depth projection radiography for IGPT
Distal spot position analysis for PBS proton therapy with CBCT
• Intrafraction liver motion analysis with cine MRI
• Weekly MRI based motion analysis and safety margin prorogation for post-prostatectomy patients underwent radiation therapy with endorectal balloons
• Perfusion SPECT guided dose escalation in radiation therapy for lung cancer patients. (PhD project, BC Cancer Agency, Vancouver, BC, 2008 – 2011)
Image registration and evaluation using ITK
Monte Carlo simulation using BEAMnrc and DOSXYZnrc
In house IMRT treatment planning program using Monte Carlo dose calculation
• Biological evaluation of MLC quality assurance: impact on dynamic MLC intensity modulated radiotherapy of prostate and head and neck cancer (in collaboration with Prof. Todd Pawlicki UCSD, 2010)
• Evaluation of the accuracy of Brain CT image segmentation results in iPlanTM (in collaboration with BrainLAB Inc, 2008 - 2009)
• Biologically guided dose painting for prostate tumor hypoxia using Volumetric Modulated Arc Therapy(VMAT) (in collaboration with Dr. Karl Otto, M.Sc project, 2006 -2007)
ACADEMIC ACTIVITIES
• Invited speaker for IBA Proton Therapy Symposium at AAPM 2014, Austin TX.
• Invited session chair of 2012 World Congress of Medical Physic and Biomedical Engineering
• Reviewer for Practical Radiation Oncology, Phys.Med.Bio. and Radiation.Oncology
• Associate Editor for Journal of Applied Clinical Medical Physics
• Highlight on the front cover of the red journal and the weekly Editor's Choice on MedicalPhysicsWeb (L.Yin et al Int.J.Rad.Oncol.Bio.Phys, 2010).
• Highlight on the European Society of Therapeutic Radiology and Oncology (ESTRO) newsletter of spring 2010 (L.Yin et al Phys.Med.Bio, 2010).
• Reviewer for the 56th Canadian Organization of Medical Physicists (COMP) annual scientific meeting (2010, Ottawa).
• Top10 best oral presentations presentation at the 55th COMP annual meeting (2009, Victoria).
Selected Publications
Y Xie, C Ainsley, L Yin, W Zou, J McDonough, T Solberg, A Lin, BK Teo: Ex vivo validation of dual energy CT proton stopping power ratio calibration. Phys.Med.Bio. 63(5), 2018.C Veiga, G Janssens, T Baudier, L Hotoiu, S Brousmiche, J McClelland, CL Teng, L Yin, G Royle and BK Teo.: A comprehensive evaluation of the accuracy of CBCT and deformable registration based dose calculation in lung proton therapy. Biomedical Physics & Engineering Express 3(1), 2017.
Y Xie, H Bentefour, G Janssens, J Smeets, F Vander, L Hotoiu, L Yin, D Dolney, S Avery, F O’Grady, D Prieels, J McDonough, T Solberg, R Lustig, A Lin, BK Teo: Prompt gamma imaging for in vivo range verification of pencil beam scanning proton therapy. Int.J.Rad.Oncol.Bio.Phys 99(1), 2017.
Wang P, Yin L, Zhang Y, Kirk M, Song G, Ahn PH, Lin A, Gee J, Dolney D, Solberg TD, Maughan R, McDonough J, Teo BK.: Quantitative assessment of anatomical change using a virtual proton depth radiograph for adaptive head and neck proton therapy. J.Appl.Clin.Med.Phys 17(2), March 2016.
C Veiga, G Janssens,CL Teng, T Baudier, L Hotoiu, J McClelland, G Royle, L Lin, L Yin, J Metz, T Solberg, Z Tochner, C Simone, J McDonough, BK Teo: First clinical investigation of CBCT and deformable registration for adaptive proton therapy of lung cancer. Int.J.Rad.Oncol.Bio.Phys 2016.
Swisher-McClure S, Yin L, Rosen M, Batra S, Berman AT, Both S, Vapiwala N.: MRI-based imaging study to assess feasibility of proton therapy for post-prostatectomy radiation. Acta Oncologica 2016.
Taku N, Dise J, Kenton O, Yin L, Teo BK, Lin LL.: Quantification of vaginal motion associated with daily endorectal balloon placement during whole pelvis radiotherapy for gynecologic cancers. Radiother Oncol 120(3), 2016.
Fernandes AT, Apisarnthanarax S, Yin L, Zou W, Rosen M, Plastaras JP, Ben-Josef E, Metz JM, Teo BK: Comparative Assessment of Liver Tumor Motion Using Cine-Magnetic Resonance Imaging versus 4-Dimensional Computed Tomography. Int.J.Rad.Oncol.Bio.Phys 91(5), April 2015.
W. Zou, L. Yin, J. Shen: Dynamic Simulation of Motion Effects in IMAT Lung SBRT. Radiat. Oncol. 9(1): 225, Nov 2014.
H Lin, X Ding, L Yin: The effects of titanium mesh on passive-scattering proton dose Phys. Med. Bio 59(81), 2014.