Department of Radiation Oncology

Alejandro Carabe-Fernandez

faculty photo

Alejandro Carabe-Fernandez, Ph.D.

Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Hospital of the University of Pennsylvania
Department of Radiation Oncology
TRC 4 West, 4-324W
3400 Civic Center Boulevard
Phiadelphia, PA 19104
Office: (215) 614-1605
MPhys (Physics with Medical Technology)
University of Hull, 2000.
MSc (Medical Physics)
University of Glasgow, 2002.
Ph.D. (Radiobiology)
Imperial College, 2008.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Proton and convencional radiotherapy

Description of Research Expertise

Clinical and theoretical radiobiology
High-LET radiobiology and radiotherapy
Radiobiological Optimization
TCP/NTCP specific for high-LET radiations
Repair kinetics modeling
Proton Arc Thereapy

Selected Publications

Shampa Chatterjee, Ralph A. Pietrofesa, Kyewon Park, Jian-Qin Tao, Thais Sielecki, Alejandro Carabe-Fernandez, Abigail T. Berman, Constantinos Koumenis, and Melpo Christofidou-Solomidou : LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks Radiation Research Society 2018.

Ulmer W, Carabe-Fernandez A: Aspect of physical principles of the proton therapy with inclusion of nuclear interactions. Journal of Proton Therapy (ISSN 2469-5491) 3: 311, 2017.

N Delso , K Stutzer , M Kirk , S Huang , D Sanchez-Parcerisa , L Lin , G Freedman , J Metz , E Abel , A Carabe-Fernandez: Proton Modulated Arc Therapy Using Mono-Energetic Beams for the Treatment of Left-Sided Breast Cancer. Medical Physics 2017.

Sanchez-Parcerisa D, Kirk M, Fager M, Burgdorf B, Stowe M, Solberg T, Carabe A.: Range optimization for mono- and bi-energetic proton modulated arc therapy with pencil beam scanning. Phys Med Biol. 61(21): N565-N574, November 2016.

Sanchez-Parcerisa D, Cortés-Giraldo MA, Dolney D, Kondrla M, Fager M, Carabe A. : Analytical calculation of proton linear energy transfer in voxelized geometries including secondary protons. Phys Med Biol. 61(4): 1705-21, Feb 2016.

Alan Mitteer R, Wang Y, Shah J, Gordon S, Fager M, Butter PP, Jun Kim H, Guardiola-Salmeron C, Carabe-Fernandez A, Fan Y. : Proton beam radiation induces DNA damage and cell apoptosis in glioma stem cells through reactive oxygen species. Sci Rep. 5: 13961, Sep 2015 Notes: DOI: 10.1038/srep13961

Guardiola, C. and Quirion, D. and Pellegrini, G. and Fleta, C. and Esteban, S. and Cortés-Giraldo, M. A. and Gómez, F. and Solberg, T. and Carabe, A. and Lozano, M: Silicon-based three-dimensional microstructures for radiation dosimetry in hadrontherapy. Applied Physics Letters 107: 023505-1, Jul 2015.

Mayer R, Lin L, Fager M, Douglas D, McDonough J, Carabe A.: Proposed linear energy transfer areal detector for protons using radiochromic film. Rev Sci Instrum. 86(4): 044301, Apr 2015 Notes: DOI: 10.1063/1.4917418

Cortés-Giraldo MA, Carabe A.: A critical study of different Monte Carlo scoring methods of dose average linear-energy-transfer maps calculated in voxelized geometries irradiated with clinical proton beams. Phys Med Biol. 60(7): 2645-69, Apr 2015 Notes: Epub 2015 Mar 13.

Fager M, Toma-Dasu I, Kirk M, Dolney D, Diffenderfer ES, Vapiwala N, Carabe A.: Linear energy transfer painting with proton therapy: a means of reducing radiation doses with equivalent clinical effectiveness. Int J Radiat Oncol Biol Phys. 91(5): 1057-64, Apr 2015.

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Last updated: 09/17/2018
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