Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Faculty

Nathaniel Dyment

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Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
424B Stemmler Hall
36th Street & Hamilton Walk
Philadelphia, PA 19104-6081
Education:
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
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Description of Research Expertise

My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.

Selected Publications

Arble Jessica R, Lalley Andrea L, Dyment Nathaniel A, Joshi Pujan, Shin Dong-Guk, Gooch Cynthia, Grawe Brian, Rowe David, Shearn Jason T: The LG/J Murine Strain Exhibits Near-Normal Tendon Biomechanical Properties Following a Full-Length Central Patellar Tendon Defect. Connective tissue research 23, Aug 2016 Notes: Epub Ahead of Print.

Matic Igor, Matthews Brya G, Wang Xi, Dyment Nathaniel A, Worthley Daniel L, Rowe David W, Grcevic Danka, Kalajzic Ivo: Quiescent bone lining cells are a major source of osteoblasts during adulthood. Stem cells (Dayton, Ohio) Aug 2016 Notes: Epub Ahead of Print.

Yoshida Ryu, Alaee Farhang, Dyrna Felix, Kronenberg Mark S, Maye Peter, Kalajzic Ivo, Rowe David W, Mazzocca Augustus D, Dyment Nathaniel A: Murine supraspinatus tendon injury model to identify the cellular origins of rotator cuff healing. Connective tissue research 16: 1-9, May 2016 Notes: Epub Ahead of Print.

Zhang Jieyu, Dyment Nathaniel A, Rowe David W, Siu Sarah Y, Sundberg John P, Uitto Jouni, Li Qiaoli: Ectopic mineralization of cartilage and collagen-rich tendons and ligaments in Enpp1asj-2J mice. Oncotarget 7(11): 12000-9, Mar 2016.

Smilowitz Henry M, Micca Peggy L, Sasso Daniel, Wu Qian, Dyment Nathanial, Xue Crystal, Kuo Lynn: Increasing radiation dose improves immunotherapy outcome and prolongation of tumor dormancy in a subgroup of mice treated for advanced intracerebral melanoma. Cancer immunology, immunotherapy : CII 65(2): 127-39, Feb 2016.

Utreja A, Dyment N A, Yadav S, Villa M M, Li Y, Jiang X, Nanda R, Rowe D W: Cell and matrix response of temporomandibular cartilage to mechanical loading. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 24(2): 335-44, Feb 2016.

Dyment NA, Huang J, Dyrna F, Rowe DW: GFP reporters within the tendon lineage display differential expression between multiple tendons and ligaments. Orthopaedic Research Society Conference 2016 Notes: Podium Presentation.

Wall Michelle E, Dyment Nathaniel A, Bodle Josie, Volmer Jon, Loboa Elizabeth, Cederlund Anna, Fox Ann M, Banes Albert J: Cell Signaling in Tenocytes: Response to Load and Ligands in Health and Disease. Advances in experimental medicine and biology 920: 79-95, 2016.

Dyrna F, Pauzenberger L, Zakko P, McCarthy MB, Rowe DW, Mazzocca A: Subacromial bursa vs bone marrow stromal cells for tendon cell-based repair. Gordon Research Conference: Musculoskeletal Biology and Bioengineering 2016 Notes: Poster Presentation.

Yoshida R, Dyment NA, Alaee F, Mazzocca A, Rowe DW: Origin of cells that contribute to murine rotator cuff tendon healing. International Symposium on Ligaments and Tendons 2016 Notes: Podium Presentation.

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Last updated: 03/10/2017
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