Penn Center for Myeloproliferative Neoplasms

Gwenn-ael H. Danet-Desnoyers

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Gwenn-ael H. Danet-Desnoyers

Adjunct Associate Professor of Medicine
Department: Medicine

Contact information
710 BRB-2/3
421 Curie Blvd
Philadelphia, PA 19104-6160
Office: 215-746-0181
Fax: 215-573-7049
Lab: 215-573-3705
B.S. (Biochemistry-Molecular Biology (Honors)
Universite Pierre et Marie Curie, Paris, France, 1988.
M.S. (Endocrinology-Biochemistry (High Honors)
Universite Pierre et Marie Curie, Paris, France, 1990.
PhD (Endocrinology-Biochemistry)
University of Florida, Gainesville, FL, 1994.
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Description of Research Expertise

Human hematopoietic and leukemic stem cells. Xenotransplantation models for human cancer stem cells and immunotherapy.

Selected Publications

Danet-Desnoyers GH, Luongo JL, Bonnet DA, Domchek SM, Vonderheide RH: Telomerase Vaccination Has No Detectable Effect on SCID-Repopulating and Colony-Forming Activities in the Bone Marrow of Cancer Patients. Exp Hematol 33(11): 1275, Nov 2005.

Taussig D, Pearce D, Simpson C, Rohatiner AZ, Lister TA, Kelly G, Luongo JL, Danet-Desnoyers GH, Bonnet DA: Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 106(13): 4086, Dec 2005.

Danet GH, Yi P, Luongo JL, Bonnet D and Simon MC: Ex-vivo expansion of SCID-repopulating cells under hypoxic conditions. Journal of Clinical Investigation 112: 126, 2003.

Danet GH, Luongo JL, Lu MM, Tenner AJ, Simon and Bonnet D: C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc. Natl. Acad. Sci. USA 99: 10441, 2002.

Smith SL, Wu MH, Danet GH, Williams SF, and Dolan ME: Optimal culture conditions to enhance transduction efficiency of exogenous DNA into CD34+ cells. Bone Marrow Transpl. 27: 1201, 2001.

Danet GH, Lee HW, Luongo JL, Simon MC and Bonnet D: Dissociation between phenotype and NOD/SCID repopulating cell activity in peripheral CD34+ cells after ex-vivo expansion. Exp. Hematol. 29: 1465, 2001.

Danet GH, SL Smith, HW Lee, MV Bennett, TF Gajewski and SF Williams: Ex-vivo expansion of mononuclear cell-derived dendritic cells: optimization for clinical applications. J. Hematotherapy 7(3): 271, 1998.

Meyer MD, Danet-Desnoyers GH, Thatcher WW, Drost M and Schalue TK Roberts RM: Treatment with recombinant bovine interferon-tau in utero attenuates secretion of prostaglandin from cultured endometrial epithelial cells. J. Dairy Sci. 79: 1375, 1996.

Danet-Desnoyers GH, Gross TS, Johnson JW and Thatcher WW: Regulation of endometrial prostaglandin synthesis during early pregnancy in cattle: effects of phospholipases and calcium in vitro. Prostaglandins 50: 313, 1995.

Thatcher WW, Meyer MD and Danet-Desnoyers GH: Maternal recognition of pregnancy. J. Reprod. Fertil. 49: 15, 1995.

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Last updated: 11/06/2017
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The Penn Difference

  • Individualized Treatment Plan
  • Expert Treatment Team Knowledgeable in Myeloproliferative Disorders
  • State-of-the-Art Personalized Diagnostic Testing
  • Access to Newest Therapies Through Clinical Trials
  • Comprehensive Bone Marrow Transplantation Service
  • Integrated Care by a Multidisciplinary Treatment Team

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Perelman Center for Advanced Medicine
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Phone: 215-615-5858 option 2
Fax: 215-615-5889

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Call the Myeloproliferative Neoplasms Program at  215-614-1847