James K Mangan
James K Mangan
Perelman Center for Advanced Medicine
12th Floor, South Pavilion
34th Street and Civic Center Blvd
Philadelphia, PA 19104
BS (Biology-Molecular, Cellular and Development)
Haverford College, 1998.
Temple University, 2005.
Ph.D. (Molecular Biology and Genetics)
Temple University, 2005.
Description of Clinical ExpertiseAcute Leukemia
Chronic Myeloid Leukemia
Allogeneic Stem Cell Transplant
Description of Research ExpertiseAcute Leukemia, novel therapies
Myelodysplastic syndromes, novel therapies
Myeloproliferative neoplasms, novel therapies
Selected PublicationsGanetsky A, Frey NV, Hexner EO, Loren AW, Gill SI, Luger SM, Mangan JK, Martin ME, Babushok DV, Drobyski WR, Smith J, Timlin C, Freyer CW, Stadtmauer EA, and Porter DL. : Tocilizumab for severe steroid-refractory acute graft-versus-host-disease of the lower gastrointestinal tract. Bone Marrow Transplantation Page: epub ahead of print, May 2018.
Kasner MT, Mick R, Jeschke GR, Carabasi M, Filicko-O'Hara J, Flomenberg N, Frey NV, Hexner EO, Luger SM, Loren AW, Mangan JK, Wagner JL, Weiss M, Carroll M, Perl AE.: Sirolimus enhances remission induction in patients with high risk acute myeloid leukemia and mTORC1 target inhibition. Invest New Drugs epub ahead of print, April 2018.
Hogan JJ, Loren AW, Denker MG, Mangan JK: Edema with hypoalbuminemia as a rare manifestation of chronic graft versus host disease after allogeneic hematopoietic cell transplant. Leukemia and Lymphoma 58(8): 2008-2010, Aug 2017.
Mesa RA, Miller CB, Thyne M, Mangan J, Goldberger S, Fazal S, Ma X, Wilson W, Paranagama DC, Dubinski DG, Naim A, Parasuraman S, Boyle J, Mascarenhas JO: Differences in treatment goals and perception of symptom burden between patients with myeloproliferative neoplasms (MPNs) and hematologists/oncologists in the United States: Findings from the MPN Landmark Survey. Cancer 123(3): 449-458, Feb 2017.
Yam C, Crisalli L, Luger SM, Loren AW, Hexner EO, Frey NV, Mangan JK, Gao A, Stadtmauer EA, Porter DL, Reshef R. : Unrelated donors are associated with improved relapse-free survival compared to related donors in patients with myelodysplastic syndrome undergoing reduced intensity allogeneic stem cell transplantation. American Journal of Hematology 91(9): 883-887, September 2016.
Frey NV, Shaw PA, Hexner EO, Gill S, Marcucci, K, Luger SM, Mangan JK, Grupp SA, Maude SL, Ericson S, Levine BL, Lacey SF, Melehorst JJ, June CH, Porter DL: Optimizing chimeric antigen receptor (CAR) T cell therapy for adult patients with relapsed or refractory (r/r) acute lymphoblastic leukemia. American Society of Clinical Oncology Annual Meeting, Chicago, IL(166823), June 2016 Notes: "Poster Presentation"
Mangan JK, Chmieliauskaite M, Stoopler ET. : An intraoral mass associated with myelodysplastic syndrome. JAMA Oncology 2(5): 679-680, May 2016.
Hexner EO, Luger SM, Reshef R, Jeschke GR, Mangan JK, Frey NV, Frank DM, Richman LP, Vonderheide RH, Aqui NA, Rosenbach M, Zhang Y, Chew A, Loren AW, Stadtmauer EA, Levine BL, June CH, Emerson SG, Porter DL.: Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment. American Journal of Hematology 91(5): 453-460, May 2016.
Mesa R, Miller CB, Thyne M, Mangan J, Goldberger S, Fazal S, Ma X, Wilson W, Paranagama DC, Dubinski DG, Boyle J, Mascarenhas JO: Myeloproliferative neoplasms (MPNs) have a significant impact on patients' overall health and productivity: the MPN Landmark Survey. BMC Cancer 16(167), Feb 2016 Notes: doi: 10.1186/s12885-016-2208-2.
Ganetsky A, Crisalli LM, Huffman AP, Acosta EP, Mangan JK, Luger SM, Loren AW, Hexner EO, Frey NV, Stadtmauer EA, Hoxie JA, Vonderheide RH, Porter DL, Reshef R. : Maraviroc concentrations are highly predictive of acute graft-versus-host-disease in reduced-intensity allogeneic stem cell transplantation. European Hematology Association Annual Meeting, Copenhagen, Denmark (331), 2016 Notes: "Poster Presentation"