Penn Center for Myeloproliferative Neoplasms

Saar I Gill

faculty photo

Saar I Gill

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine
Graduate Group Affiliations

Contact information
Room 8-101
Smilow Translational Research Center
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 573-4015
Lab: (215) 573-4015
Education:
MBBS (medicine)
University of Melbourne, 1999.
PhD (immunology)
University of Melbourne, 2011.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Blood and Marrow Transplantation
Leukemia
Myelodysplastic Syndromes
Myeloproliferative Neoplasms
Lymphoproliferative Neoplasms
Bone Marrow Failure

Description of Research Expertise

Tumor Immunology
Chimeric Antigen Receptor T cells
Mouse Models of Human Leukemia
Murine Xenografts
Adoptive Cellular Therapy
Genetic Engineering of T cells
Flow Cytometry

Selected Publications

Ganetsky Alex, Frey Noelle V, Hexner Elizabeth O, Loren Alison W, Gill Saar I, Luger Selina M, Mangan James K, Martin Mary Ellen, Babushok Daria V, Drobyski William R, Smith Jacqueline, Timlin Colleen, Freyer Craig W, Stadtmauer Edward A, Porter David L: Tocilizumab for the treatment of severe steroid-refractory acute graft-versus-host disease of the lower gastrointestinal tract. Bone marrow transplantation May 2018.

Kim Miriam Y, Yu Kyung-Rok, Kenderian Saad S, Ruella Marco, Chen Shirley, Shin Tae-Hoon, Aljanahi Aisha A, Schreeder Daniel, Klichinsky Michael, Shestova Olga, Kozlowski Miroslaw S, Cummins Katherine D, Shan Xinhe, Shestov Maksim, Bagg Adam, Morrissette Jennifer J D, Sekhri Palak, Lazzarotto Cicera R, Calvo Katherine R, Kuhns Douglas B, Donahue Robert E, Behbehani Gregory K, Tsai Shengdar Q, Dunbar Cynthia E, Gill Saar: Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Cell 173(6): 1439-1453.e19, May 2018.

Mathew Nimitha R, Baumgartner Francis, Braun Lukas, O'Sullivan David, Thomas Simone, Waterhouse Miguel, Müller Tony A, Hanke Kathrin, Taromi Sanaz, Apostolova Petya, Illert Anna L, Melchinger Wolfgang, Duquesne Sandra, Schmitt-Graeff Annette, Osswald Lena, Yan Kai-Li, Weber Arnim, Tugues Sonia, Spath Sabine, Pfeifer Dietmar, Follo Marie, Claus Rainer, Lübbert Michael, Rummelt Christoph, Bertz Hartmut, Wäsch Ralph, Haag Johanna, Schmidts Andrea, Schultheiss Michael, Bettinger Dominik, Thimme Robert, Ullrich Evelyn, Tanriver Yakup, Vuong Giang Lam, Arnold Renate, Hemmati Philipp, Wolf Dominik, Ditschkowski Markus, Jilg Cordula, Wilhelm Konrad, Leiber Christian, Gerull Sabine, Halter Jörg, Lengerke Claudia, Pabst Thomas, Schroeder Thomas, Kobbe Guido, Rösler Wolf, Doostkam Soroush, Meckel Stephan, Stabla Kathleen, Metzelder Stephan K, Halbach Sebastian, Brummer Tilman, Hu Zehan, Dengjel Joern, Hackanson Björn, Schmid Christoph, Holtick Udo, Scheid Christof, Spyridonidis Alexandros, Stölzel Friedrich, Ordemann Rainer, Müller Lutz P, Sicre-de-Fontbrune Flore, Ihorst Gabriele, Kuball Jürgen, Ehlert Jan E, Feger Daniel, Wagner Eva-Maria, Cahn Jean-Yves, Schnell Jacqueline, Kuchenbauer Florian, Bunjes Donald, Chakraverty Ronjon, Richardson Simon, Gill Saar, Kröger Nicolaus, Ayuk Francis, Vago Luca, Ciceri Fabio, Müller Antonia M, Kondo Takeshi, Teshima Takanori, Klaeger Susan, Kuster Bernhard, Kim Dennis Dong Hwan, Weisdorf Daniel, van der Velden Walter, Dörfel Daniela, Bethge Wolfgang, Hilgendorf Inken, Hochhaus Andreas, Andrieux Geoffroy, Börries Melanie, Busch Hauke, Magenau John, Reddy Pavan, Labopin Myriam, Antin Joseph H, Henden Andrea S, Hill Geoffrey R, Kennedy Glen A, Bar Merav, Sarma Anita, McLornan Donal, Mufti Ghulam, Oran Betul, Rezvani Katayoun, Shah Omid, Negrin Robert S, Nagler Arnon, Prinz Marco, Burchert Andreas, Neubauer Andreas, Beelen Dietrich, Mackensen Andreas, von Bubnoff Nikolas, Herr Wolfgang, Becher Burkhard, Socié Gerard, Caligiuri Michael A, Ruggiero Eliana, Bonini Chiara, Häcker Georg, Duyster Justus, Finke Jürgen, Pearce Erika, Blazar Bruce R, Zeiser Robert: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nature medicine 24(3): 282-291, Mar 2018.

Hosoya Hitomi, Levine Jeffrey, Abt Peter, Henry David, Porter David L, Gill Saar: Toward dual hematopoietic stem-cell transplantation and solid-organ transplantation for sickle-cell disease. Blood advances 2(5): 575-585, Mar 2018.

Uribe-Herranz Mireia, Bittinger Kyle, Rafail Stavros, Guedan Sonia, Pierini Stefano, Tanes Ceylan, Ganetsky Alex, Morgan Mark A, Gill Saar, Tanyi Janos L, Bushman Frederic D, June Carl H, Facciabene Andrea: Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12. JCI insight 3(4), Feb 2018.

Cummins KD*, Frey N*, Nelson AM*, Schmidt A*, Luger S, Isaacs RE*, Lacey SF, Hexner E, Melenhorst JJ, June CH, Porter DL, Gill SI. : Treating Relapsed / Refractory (RR) AML with Biodegradable AntiCD123 CAR Modified T Cells American Society for Hematology Annual Meeting, Atlanta, GA Dec 2017 Notes: "Poster Presentation"

Ruella M*, Maude SL*, Engels B*, Barrett DM*, Frey N*, Marcucci K,Shestova O, Singh N, Perazzelli J, Christian DA, Hunter CA, Haagen D, Lacey S, Melenhorst J, Brogdon J, Young R, Porter DL, June CH, Grupp S, Gill S.: Clinical efficacy of anti-CD22 chimeric antigen receptor T cells for B-cell acute lymphoblastic leukemia is correlated with the length of the scFv linker and can be predicted using xenograft models. American Society for Hematology Annual Meeting, Atlanta, GA Dec 2017 Notes: "Oral Presentation"

Ruella M, Xu J, Barrett DM*, Kulikovskaya I*, Ambrose DE*, Patel PR*, Reich T*, Scholler J*, Nazimuddin F*, Fraietta JA*, Maude SL, Gill SI, Levine BL, Nobles CL*, Bushman FD*, Orlando E*, Grupp SA, June CH, Melenhorst JJ, Lacey SF.: Iatrogenic Induction of Chimeric Antigen Receptor Therapy Resistance American Society of Hematology Annual Meeting, Atlanta, GA Dec 2017 Notes: "Poster Presentation"

Ruella M, Klichinsky M, Kenderian SS, Shestova O, Ziober A, Kraft DO, Feldman M, Wasik MA, June CH, Gill S: Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells. Cancer Discovery 7(10): 1154-67, Oct 2017 Notes: doi: 10.1158/2159-8290.

Cummins Katherine D, Gill Saar: Anti-CD123 chimeric antigen receptor T-cells (CART): an evolving treatment strategy for hematological malignancies, and a potential ace-in-the-hole against antigen-negative relapse. Leukemia & lymphoma Page: 1-15, Sep 2017.

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Last updated: 06/05/2018
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The Penn Difference

  • Individualized Treatment Plan
  • Expert Treatment Team Knowledgeable in Myeloproliferative Disorders
  • State-of-the-Art Personalized Diagnostic Testing
  • Access to Newest Therapies Through Clinical Trials
  • Comprehensive Bone Marrow Transplantation Service
  • Integrated Care by a Multidisciplinary Treatment Team

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