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Nicholas A. Pawlowski, M.D.

Nicholas A. Pawlowski, M.D.

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Clinical Associate Professor of Pediatrics
Department: Pediatrics

Contact information
CHOP Specialty Care Center at King of Prussia
210 Mall Boulevard
King of Prussia, PA 19406
Office: 215-590-6457
Fax: 215-590-2340
Education:
B.S. (Biology and Religion)
Dickinson College, 1972.
M.D.
Georgetown University, 1976.
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Description of Clinical Expertise

1. Asthma clinical care: Building on my long term ivolvement with the management of children and adolescents with asthma, I have developed expertise in diagnosis and management. I have also had a long term teaching experience with families, nursing, physicians in training, and general and subupecialty physicians, and individuals in industry. This has contributed to the recognition of Allergy to a a leader in asthma care within our institution. Further, my efforts have led to new approaches and protocols at CHOP. Together with Dr. Mark Magnusson, I helped to develop the currently employed inpatient asthma management paradigm at CHOP. Next, I led the effort to create an asthma initiative at CHOP. This mulidisciplinary task force created a standardized asthma care plan now incorporated into our electronic medical record (EPIC). This is used to compile one of the key performance measures for our institution. Previously, the basic concept and structure of this tool was developed by myself while I led the Allergy Section. During the asthma initiative, I also led the creation of CHOP's own asthma control tool which was brought to fruition by Dr. Joe Zorc as part of his masters degree completion. This is part of our medical record as well. Our key leadership from this initiative transitioned into advisory group actively refining asthma management for our clinical operations at CHOP. Finally, I asked the Pathology Laboratory at CHOP to develop a molecular pathogy test for genotyping the beat adrenergic receptor to help identify those asthma patients who are at risk for complications form albuterol overuse. I continue to use this experience while beginning my own textbook guide to asthma management in children and adolescents.

2. Food allergy: During the development of the Allergy program at CHOP, I created our food challenge program. At the outset, there was little national experience in this procedure. This program has grown because of its pivotal role in food allergy management. We now have the largest volume of pediatric food challenges performed in the US. I continue to perform challenges in our Division. And I continue to provide food allergy diagnosis and management for all presentations of food allergy in childhood. Over time, I have continued to see a large volume of referrals. A particular interest is the diagnosis and management of food protein-induced enterocolitis syndrome (FPIES).

3. Pediatric Allergy consultation: During my years in leadership as Allergy Chief at CHOP and in my continued practice within the CHOP system, I have developed a broad experience in all types of childhood allergy problems.

Selected Publications

Andrews, T., McGintee, E., Mittal, M.K., Tyler, L., Chew, A., Zhang, X., Pawlowski, N., and Zorc, J.J.: High-Dose Continuous Nebulized Levalbuterol for Pediatric Status Asthmaticus: A Randomized Trial. Journal of Pediatrics 155: 205-210.e1.Epub, 2009.

McGintee, E.E., Kaur, T., Blackstone, M., Chew, A., Magnusson, M., Pawlowski, N., and Zorc, J.J.: Oral Prednisolone Dosing in Children Hospitalized with Asthma. Journal of Allergy and Clinical Immunology 121: S8, 2008.

Andrews, T., McGintee, E., Tyler,L., Mittal, M., Chew, A., Pawlowski, N., and Zorc, J.J.: Efficacy of High-Dose Continuous Nebulized Levalbuterol for Pediatric Status Asthmaticus. Journal of Allergy and Clinical Immunology 119: S244, 2007.

Fogg, M.I., Brown-Whitehorn, T., Pawlowski, N.A., and Spergel, J.M.: Atopy patch test for the diagnosis of food protein-induced enterocolitis syndrome. Pediatric Allergy and Immunology 5: 351-5, 2006.

Zorc, J.J., Pawlowski, N.A., Allen, J.A., Bryant-Stephens, T., Winston, M., Angsuco, C, and Shea, J. : Development and Validation of an instrument to measure asthma symptom control in children. Journal of Asthma 43: 753-58, 2006.

Spergel, JM, Beausoleil, JA, and NA Pawlowski.: Resolution of childhood peanut allergy. Annals of Allergy Asthma and Immunology 85: 473-476, 2000.

Scott, W.A., Pawlowski, N.A., Murray, H.W., Andreach, M., Cohn, Z.A. : The regulation of arachidonic acid metabolism by macrophage activation. Journal of Experimental Medicine 155: 1148-1160, 1982.

Pawlowski, N.A., Scott, W.A., Andreach, M., Cohn, Z.A. : Uptake and metabolism of mono-hydroxyeicosatetraenoic acids by macrophages. Journal of Experimental Medicine 156: 1653-1664, 1982.

Fels, A.O.S., Pawlowski, N.A., Cramer, E.B., Cohn, Z.A., Scott, W.A. : Human alveolar macrophages produce leukotriene B4. Proceedings of the National Academy of Sciences USA 79: 7866-7870, 1982.

Pawlowski, N.A., Kaplan, G., Hamill, A.L., Cohn, A.Z., Scott, W.A. : Arachidonic acid metabolism by human monocytes. Studies with platelet-depleted cultures. Journal of Experimental Medicine 158: 393-412, 1983.

Pawlowski, N.A., Kaplan, G., Abraham, E., Cohn, Z.A.: The Selective binding and trans-migration of monocytes through the junctional complexes of human endothelium. Journal of Experimental Medicine 168: 1865-1882, 1988.

Pang, T., Dev.,S., Puthucheary, S., Pawlowski, N.A.: Heat-killed Salmonella typhi induces the release of prostaglandins and leukotrienes from mouse macrophages. Microbiology and Immunolology 35: 267-271 1991.

Amirav, I., Goren, A., Pawlowski, N.A. What: What do pediatric residents know about the correct use of inhalers and spacer devices? Journal of Allergy and Clinical Immunology 94: 669-75, 1994.

Amirav, I., Goren, A., Kravitz, R.M., Pawlowski, N.A.: Physician-targeted program on inhaled therapy in childhood asthma. Journal of Allergy and Clinical Immunology 95: 818-823, 1995.

Kwittken, P.L., Sweinberg, S., Pawlowski, N.A.: Latex hypersensitivity in children: Clinical characteristics and detection of latex-specific IgE. Pediatrics 95: 693-699, 1995.

Kobrynski, L., Tanimune, L., Pawlowski, N.A., Douglas, S.D., Campbell, D.E.: A comparison of electrochemiluminescence and flow cytometry for the detection of natural latex-specific human immunoglobulin E. Clinical and Diagnostic Laboratory Immunology 3: 42-46, 1996.

Chung, E.K., Casey, R., Bell, L.M., Pawlowski, N.A., Pinto-Martin, J. : Immunization rates in children with asthma. Annals of Allergy Asthma and Immunology 80: 318-322, 1998.

Pawlowski, N.A.: Arachidonic acid metabolism by human monocytes Human Monocytes. Asherson, G.L.G., Zembala, M. (eds.). Academic Press, London, Page: 273-289, 1989.

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Last updated: 08/28/2014
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