William M. Armstead, BA, MS, PhD
William M. Armstead, BA, MS, PhD
Research Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations
Contact information
Department of Anesthesiology and Critical Care
3620 Hamilton Walk, JM3
Philadelphia, PA 19104-4283
3620 Hamilton Walk, JM3
Philadelphia, PA 19104-4283
Office: 215-573-3674
Fax: 215-349-5078
Fax: 215-349-5078
Email:
armsteaw@uphs.upenn.edu
armsteaw@uphs.upenn.edu
Publications
Links
Search PubMed for articles
Department of Anesthesiology and Critical Care
Pharmacological Sciences Graduate Group Faculty
Search PubMed for articles
Department of Anesthesiology and Critical Care
Pharmacological Sciences Graduate Group Faculty
Education:
B.A. (Biochemistry)
University of Pennsylvania, 1979.
M.S. (Pharmacology)
Tulane University, 1983.
Ph.D. (Pharmacology)
Tulane University, 1985.
Permanent linkB.A. (Biochemistry)
University of Pennsylvania, 1979.
M.S. (Pharmacology)
Tulane University, 1983.
Ph.D. (Pharmacology)
Tulane University, 1985.
Description of Research Expertise
Research InterestsControl of cerebral hemodynamics during physiologic and pathologic conditions such as traumatic brain injury, stroke, and cerebral ischemia/reperfusion.
Research Techniques
Closed cranial window for measurement of pial artery diameter and collection of cortical periarachnoid CSF for vasoactive metabolite concentration determination by RIA, fluid percussion brain injury, global cerebral ischemia, photothrombotic cerebral injury, radiolabelled microsphere regional cerebral blood flow determination.
Research Summary
Dr. Armstead's research focuses on characterizing mechanisms important in the control of cerebral hemodynamics under physiologic and pathologic conditions such as traumatic brain injury (TBI), stroke, and cerebral hypoxia/ischemia, particularly in the newborn. Current projects focus on interactions between the NMDA receptor and plasminogen activators after TBI, optimizing the efficacy/toxicity ratio of tPA, the only FDA approved treatment for stroke and translational research concerning the roles of sex and age in outcome after pediatric TBI.
Key Words
tPA, adrenomedullin, newborn, brain injury, stroke, endothelin, nitric oxide, cerebral circulation
Selected Publications
Armstead WM, Riley J, Yarovoi S, Cines DB, Smith DH, Higazi AA: tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury. J Neurotrauma 29: 1794-1802, 2012.Armstead WM, Riley J, Vavilala MS.: TBI sex dependently upregulates ET-1 to impair autoregulation which is aggravated by phenylephrine in males but is abrogated in females. J Neurotrauma 29: 1483-1490, 2012.
Armstead WM, Ganguly K, Riley J, Zaitsev S, Cines DB, Higazi AAR, Muzykantov VR.: RBC-coupled tPA prevents whereas tPA aggravates JNK MAPK mediated impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after cerebral photothrombosis Translational Stroke Research 3: 114-121, 2012.
Diansan Su, Riley John, Armstead William M, Liu Renyu.: Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via ERK MAPK in piglets. Anesthesia and Analgesia 114: 200-204, 2012.
Armstead WM, Riley J, Cines DB, Higazi AAR.: Combination therapy with glucagon and a novel plasminogen activator inhibitor-1 derived peptide enhances protection against cerebrovasodilation during hypotension after traumatic brain injury through inhibition of ERK and JNK MAPK. Neurological Research 34: 530-537, 2012.
Armstead WM, Riley J, Cines DB, Higazi AAR. : tPA contributes to impairment of ATP and calcium sensitive K channel mediated cerebrovasodilation afer hypoxia/ischemia through upregulation of ERK MAPK. Brain Res 1376: 88-93, 2011.
Armstead WM, Kiessling JW, Riley J, Cines DB, Higazi AAR: tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK. Neurological Research 33: 726-733, 2011.
Armstead WM, Ganguly K, Riley J, Kiessling JW, Cines DB, Higazi AAR, Zaitsev S, Muzykantov VR. : RBC-coupled tPA prevents impairment of cerebral vasodilatory responses through inhibition of JNK and potentiation of p38 MAPK after cerebral photo thrombosis in the newborn pig. Ped Crit Care Med 1231: 369-375, 2011.
Armstead WM, Kiessling JW, Cines DB, Higazi AAR.: Glucagon protects against impaired NMDA-mediated cerebrovasodilation and cerebral autoregulation during hypotension after brain injury by activating cAMP protein kinase A anad inhibiting upregulation of tPA. J Neurotrauma 28: 451-457, 2011.
Armstead WM, Kiessling JW, Riley J, Kofke WA, Vavilala MS. : Phenylephrine infusion prevents impairment of ATP and Calcium sensitive K channel mediated cerebrovasodilation after brain injury in female but aggravates impairment in male piglets through modulation of ERK MAPK upregulation. J Neurotrauma 28: 105-111, 2011.