Home | News | Directories | Calendar | Maps | Contact Us | Webmail
Perelman School of Medicine at the University of Pennsylvania Advanced Search

Claire H. Mitchell, Ph.D.

Claire H. Mitchell, Ph.D.

faculty photo
Associate Professor of Anatomy & Cell Biology
Department: Anatomy & Cell Biology
Graduate Group Affiliations

Contact information
440 Levy Bldg
240 S. 40th St
Philadelphia, PA 19104
Office: (215) 573-2176
Education:
B.Sc. (Biology)
McGill University, Montreal, Canada, 1986.
Ph.D. (Ion Channels of Ocular Epithelia)
Institute of Ophthalmology, University College London, U.K., 1994.
Permanent link
 
Perelman School of Medicine > Faculty > Search

Description of Research Expertise

My research is concerned with the basic physiological mechanisms that interfere with the survival of neurons, astrocytes and epithelial cells as we age.

Selected Publications

Guha Sonia, Liu Ji, Baltazar Gabe, Laties Alan M, Mitchell Claire H: Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells. Advances in experimental medicine and biology 801: 105-11, 2014.

Coffey EE, Beckel. JM, Laties AM, Mitchell CH. : Lysosomal alkalization and dysfunctional autphagy in fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP Neuroscience 263: 111-124. 2014.

Guha S, Baltazar GC, Coffey EE, Tu LA, Lim JC, Beckel JM, Patel S, Eysteinsson T, Lu W, O'Brien-Jenkins A, Laties AM, Mitchell CH.: Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor. FASEB J 27(11): 4500-4509, Nov 2013.

Frost LS, Lopes VS, Stefano FP, Bragin A, Williams DS, Mitchell CH, Boesze-Battaglia K.: Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium. Visual Neuroscience 30(3): 55-64, 2013.

Guha S, Baltazar GC, Tu L-A, Liu J, Lim JC, Lu W, Argall A, Boesze-Battaglia K, Laties AM, Mitchell CH: Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. Journal of Neurochemistry 122(4): 823-33, Aug 2012.

Xia J, Lim JC, Lu W, Beckel JM, Macarak EJ, Laties AM, Mitchell CH: Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. Journal of Physiology 590(Pt 10): 2285-304, May 2012.

Li A, Leung CT, Peterson-Yantorno K, Stamer WD, Mitchell CH, Civan MM: Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. Journal of Cellular Physiology 227(1): 172-82, Jan 2012.

Lim JC, Mitchell CH : Inflammation, pain, and pressure - Purinergic signaling in oral tissues Journal of Dental Research 91(12): 1103-1109, 2012.

Liu J, Lu W, Guha S, Baltazar GC, Coffey EE, Laties AM, Rubenstein RC, Reenstra WW, Mitchell CH: Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells. American Journal of Physiology: Cell Physiology 303(2): C160-9, 2012.

Baltazar GC, Guha S, Lu W, Lim J, Boesze-Battaglia K, Laties AM, Tyagi P, Kompella UB, Mitchell CH: Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells. PloS one 7(12): e49635, 2012.

back to top
Last updated: 03/25/2014
The Trustees of the University of Pennsylvania