Norman M. Schechter, Ph.D
Norman M. Schechter, Ph.D
Research Professor of Dermatology
Department: Dermatology
Contact information
University of Pennsylvania
Department of Dermatology
Rm. 118 Clinical Research Building
415 Curie Blvd.
Philadelphia, PA 19104
Department of Dermatology
Rm. 118 Clinical Research Building
415 Curie Blvd.
Philadelphia, PA 19104
Office: 2152649463
Lab: 2155733306
Lab: 2155733306
Email:
SCHECHTE@MAIL.MED.UPENN.EDU
SCHECHTE@MAIL.MED.UPENN.EDU
Education:
B.S. (Biology)
State University of New York at Stony Brook, 1969.
Ph.D. (Biochemistry)
Duke University, 1975.
Permanent linkB.S. (Biology)
State University of New York at Stony Brook, 1969.
Ph.D. (Biochemistry)
Duke University, 1975.
Description of Research Expertise
Structure and function of serine proteasesRole of serine proteases in inflammation and skin development
Regulation of serine proteases by inhibitor-dependent and non-inhibitor processes
Selected Publications
Schechter, N. M., Choi, E-J., Wang, Z-M., Hanakawa, Y., Stanley, J. R., Kang, Y., Clayman, G. L., and Jayakumar. A.: Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor, Lympho-Epithelial Kazal Type Inhibitor (LEKTI). Biol. Chem. 386: 1173-1184, 2005.Selwood, T., Smolensky, H,, McCaslin, D. R., and Schechter, N. M.: The interaction of human tryptase-ß with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease. Biochemistry 44: 3580-3590, 2005.
Wong, T., Groutas, C. S., Mohan, S., Lai, A., Alliston, K. R., Vu, N., Schechter, N. M., and Groutas, W. C. : 1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase. Arch. Biochem. Biophysic. 436: 1-7, 2005.
Hanakawa, Y., Schechter, N. M. Lin C., Nishifuji, K., Amagai, M. and Stanley, J. R. : Enzymatic and molecular characteristics of the efficiency and specificity of exfoliative toxin cleavage of desmoglein 1. J. Biol. Chem. 279: 5268-5277, 2004.
Howard, P. S., Renfrow, D, Schechter, N. M., and Kucich, U. : Mast cell chymase is a possible mediator of neurogenic bladder fibrosis. Neurourology and Urodynamics 23: 374-382: 2004.
Selwood, T., Elrod, K. C., and Schechter, N. M. : Potent bivalent inhibition of human tryptase-ß by a synthetic inhibitor. Biol. Chem. 384: 1605-1611, 2003.
Hanakawa, Y., Selwood, T., Woo, D., Lin, C., Schechter, N. M., and Stanley, J. R. : Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin. J. Invest. Dermatol. 121: 383-398, 2003.
Plotnick, M. I., Rubin, H., and Schechter, N. M. : The effects of reactive site location on the inhibitory properties of the serpin alpha 1-antichymotrypsin. J. Biol. Chem. 277: 29972-29935, 2002.
Hanakawa, Y., Schechter, N. M., Lin, C., Garza, L., Li, H., Yamaguchi, T., Fudaba, Y., Nishifujr, K., Sugar, M., Amagai, M., and Stanley, J. R. : Molecular mechanisms of blister formation in bullous impegito, and Staphylococcal scalded skin syndrome. J. Clin. Invest. 110: 53-60, 2002.
Lazaar, A. L., Plotnick, M. I., Kucich, U., Crichton, I., Das, S. K. P., Kane, S., Rosenbloom, J., Panettieri, R. A. Jr., Schechter, N. M., Puré, E: Mast cell chymase releases soluble CD44 and fibronectin while inhibiting mitogen-induced proliferation of human airway smooth muscle cells. J. Immunol. 169: 1014-1020, 2002.