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Norman M. Schechter, Ph.D

Norman M. Schechter, Ph.D

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Research Professor of Dermatology
Department: Dermatology

Contact information
University of Pennsylvania
Department of Dermatology
Rm. 118 Clinical Research Building
415 Curie Blvd.
Philadelphia, PA 19104
Office: 2152649463
Lab: 2155733306
Education:
B.S. (Biology)
State University of New York at Stony Brook, 1969.
Ph.D. (Biochemistry)
Duke University, 1975.
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Description of Research Expertise

Structure and function of serine proteases
Role of serine proteases in inflammation and skin development
Regulation of serine proteases by inhibitor-dependent and non-inhibitor processes

Selected Publications

Schechter, N. M., Choi, E-J., Wang, Z-M., Hanakawa, Y., Stanley, J. R., Kang, Y., Clayman, G. L., and Jayakumar. A.: Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor, Lympho-Epithelial Kazal Type Inhibitor (LEKTI). Biol. Chem. 386: 1173-1184, 2005.

Selwood, T., Smolensky, H,, McCaslin, D. R., and Schechter, N. M.: The interaction of human tryptase-ß with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease. Biochemistry 44: 3580-3590, 2005.

Wong, T., Groutas, C. S., Mohan, S., Lai, A., Alliston, K. R., Vu, N., Schechter, N. M., and Groutas, W. C. : 1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase. Arch. Biochem. Biophysic. 436: 1-7, 2005.

Hanakawa, Y., Schechter, N. M. Lin C., Nishifuji, K., Amagai, M. and Stanley, J. R. : Enzymatic and molecular characteristics of the efficiency and specificity of exfoliative toxin cleavage of desmoglein 1. J. Biol. Chem. 279: 5268-5277, 2004.

Howard, P. S., Renfrow, D, Schechter, N. M., and Kucich, U. : Mast cell chymase is a possible mediator of neurogenic bladder fibrosis. Neurourology and Urodynamics 23: 374-382: 2004.

Selwood, T., Elrod, K. C., and Schechter, N. M. : Potent bivalent inhibition of human tryptase-ß by a synthetic inhibitor. Biol. Chem. 384: 1605-1611, 2003.

Hanakawa, Y., Selwood, T., Woo, D., Lin, C., Schechter, N. M., and Stanley, J. R. : Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin. J. Invest. Dermatol. 121: 383-398, 2003.

Plotnick, M. I., Rubin, H., and Schechter, N. M. : The effects of reactive site location on the inhibitory properties of the serpin alpha 1-antichymotrypsin. J. Biol. Chem. 277: 29972-29935, 2002.

Hanakawa, Y., Schechter, N. M., Lin, C., Garza, L., Li, H., Yamaguchi, T., Fudaba, Y., Nishifujr, K., Sugar, M., Amagai, M., and Stanley, J. R. : Molecular mechanisms of blister formation in bullous impegito, and Staphylococcal scalded skin syndrome. J. Clin. Invest. 110: 53-60, 2002.

Lazaar, A. L., Plotnick, M. I., Kucich, U., Crichton, I., Das, S. K. P., Kane, S., Rosenbloom, J., Panettieri, R. A. Jr., Schechter, N. M., Puré, E: Mast cell chymase releases soluble CD44 and fibronectin while inhibiting mitogen-induced proliferation of human airway smooth muscle cells. J. Immunol. 169: 1014-1020, 2002.

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Last updated: 10/19/2012
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