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Edward B Lee, MD, PhD

Edward B Lee, MD, PhD

faculty photo
Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
605B Stellar Chance Laboratories
422 Curie Blvd
Philadelphia, PA 19104
Office: 215-898-0908
Lab: 215-662-6696
Education:
BS (Biological Sciences)
Stanford University, 1997.
PhD (Neuroscience)
University of Pennsylvania School of Medicine, 2004.
MD
University of Pennsylvania School of Medicine, 2005.
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Description of Clinical Expertise

Neuropathology

Description of Research Expertise

Alzheimer's disease
Frontotemporal lobar degeneration
Amyotrophic lateral sclerosis

Selected Publications

Liu Elaine Y, Russ Jenny, Wu Kathryn, Neal Donald, Suh Eunran, McNally Anna G, Irwin David J, Van Deerlin Vivianna M, Lee Edward B: C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD. Acta neuropathologica May 2014.

Lee Edward B, Russ Jenny, Jung Hyunjoo, Elman Lauren B, Chahine Lama M, Kremens Daniel, Miller Bruce L, Branch Coslett H, Trojanowski John Q, Van Deerlin Vivianna M, McCluskey Leo F: Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U. Acta neuropathologica communications 1(9): 1-11, May 2013.

Wood Elisabeth M, Falcone Dana, Suh Eunran, Irwin David J, Chen-Plotkin Alice S, Lee Edward B, Xie Sharon X, Van Deerlin Vivianna M, Grossman Murray: Development and validation of pedigree classification criteria for frontotemporal lobar degeneration. JAMA neurology 70(11): 1411-7, Nov 2013.

Brettschneider Johannes, Tredici Kelly Del, Toledo Jon B, Robinson John L, Irwin David J, Grossman Murray, Suh Eunran, Van Deerlin Vivianna M, Wood Elisabeth M, Baek Young, Kwong Linda, Lee Edward B, Elman Lauren, McCluskey Leo, Fang Lubin, Feldengut Simone, Ludolph Albert C, Lee Virginia M-Y, Braak Heiko, Trojanowski John Q: Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Annals of neurology 74(1): 20-38, May 2013.

Lee Edward B, Lee Virginia M-Y, Trojanowski John Q: Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature reviews. Neuroscience 13(1): 38-50, Nov 2011.

Igaz Lionel M, Kwong Linda K, Lee Edward B, Chen-Plotkin Alice, Swanson Eric, Unger Travis, Malunda Joe, Xu Yan, Winton Matthew J, Trojanowski John Q, Lee Virginia M-Y: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of clinical investigation 121(2): 726-38, Feb 2011.

Lee Edward B, Mattson Mark P: The neuropathology of obesity: insights from human disease. Acta neuropathologica 127(1): 3-28, Jan 2014.

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Last updated: 05/08/2014
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