Dean C. Carlow, M.D., Ph.D
Dean C. Carlow, M.D., Ph.D
Associate Professor of Clinical Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
Children’s Hospital of Philadelphia
Department of Pathology and Laboratory Medicine
5144 Main Building
34th Street and Civic Center Blvd.
Philadelphia, PA 19104
Department of Pathology and Laboratory Medicine
5144 Main Building
34th Street and Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-5537
Email:
carlow@email.chop.edu
carlow@email.chop.edu
Education:
B.S.
Syracuse University, Syracuse, NY, 1989.
Ph.D. (Biochemistry and Biophysics )
University of North Carolina at Chapel Hill, 1994.
M.D.
University of North Carolina School of Medicine, Chapel Hill, North Carolina, 2000.
Permanent linkB.S.
Syracuse University, Syracuse, NY, 1989.
Ph.D. (Biochemistry and Biophysics )
University of North Carolina at Chapel Hill, 1994.
M.D.
University of North Carolina School of Medicine, Chapel Hill, North Carolina, 2000.
Description of Research Expertise
Pediatric Clinical ChemistryPediatric Laboratory Reference Values
Assay development
Description of Clinical Expertise
General pediatric clinical chemistry/toxicology/endocrinologyDescription of Other Expertise
Tandem mass spectrometryICP mass spectrometry/trace metal analysis
High Performance Liquid Chromatography
Selected Publications
Carlow, D. C., Carter, C. C., Mejlhede, N., Neuhard, J., and Wolfenden, R. : Cytidine Deaminase from B. subtilis and E. coli: Compensating Effects of Changing Zinc Coordination and Quaternary Structure. Biochemistry 38: 12258 - 12265, 1999.Carlow, D. C., Morrison, T., Castillo, M.: AJR Case of the Week. eAmerican Journal of Roentgenology October 1999.
Carlow, D. C. & Wolfenden, R. V.: Substrate Connectivity Effects in the Transition State for Cytidine Deaminase. Biochemistry 37: 11873-11878, 1998.
Carlow, D. C., Short, S. A., and Wolfenden, R. V: Complementary Truncations of a Hydrogen Bond to Ribose Involved in Transition-State Stabilization by Cytidine Deaminase. Biochemistry 37: 1199-1203, 1998.
Lewis, J.P., Carter, C.W., Hermans, J., Pan, W., Lee, W. & W. Yang. : Active Species for the Ground-State Complex of Cytidine Deaminase: A Linear-Scaling Quantum Mechanical Investigation. J. Am. Chem. Soc. 120: 5407, 1998.
Miller, B.G., Traut, T.W., & R. Wolfenden. A : Role for Zinc in OMP Decarboxylase, an Unusually Proficient Enzyme J. Am. Chem. Soc. 120: 2666, 1998.
Carlow, D. C., Short, S. A., and Wolfenden, R. V. : Role of Glu-104 in Generating a Transition State Analogue Inhibitor at the Active Site of Cytidine Deaminase. Biochemistry 35: 948-954, 1996.
Carlow, D. C., Smith, A. A., Short, S. A., and Wolfenden: Major Contribution of a Carboxymethyl Group to Transition State Stabilization by Escherichia coli Cytidine Deaminase. Biochemistry 34: 4220-4224, 1995.
Smith, A.A., Carlow, D.C., Wolfenden, R.V., and Short, S.A. : Mutations Affecting Transition State Stabilization by Residues Coordinating Zinc at the Active Site of Cytidine Deaminase. Biochemistry 33: 6468-6474, 1994.
Yang, C., Carlow, D., Wolfenden, R., and Short, S.A. : Cloning and Nucleotide Sequence of the Escherichia coli Cytidine Deaminase (cdd) Gene. Biochemistry 31: 4168-4174, 1993.