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Jonathan M. Spergel, MD, PhD

Jonathan M. Spergel, MD, PhD

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Professor of Pediatrics at the Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
3550 Market Street, Rm 3050
Children’s Hospital of Philadelphia
Philadelphia, PA 19104
Office: 215-590-6992
Fax: 2155904529
Education:
A.B. (Chemistry)
Princeton University, 1985.
M.D.
Mt. Sinai School of Medicine, 1992.
Ph.D. (Biomedical Sciences)
Mt. Sinai School of Medicine, 1992.
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Description of Research Expertise

eosinophilic esophagitis, food allergy, gastrointestinal food allergy and atopic dermatitis

Description of Clinical Expertise

atopic dermatitis, food allergy, asthma, allergic rhinitis, general allergy and immunology

Selected Publications

Jyonouchi, S, Smith, CL, Saretta, F, Abraham, V, Ruymann, KR, Modayur-Chandramouleeswaran, P, Wang, ML, Spergel, JM, Cianferoni, A: Invariant Natural Killer T cells in Children with Eosinophilic Esophagitis. Clin Exp Allergy 44(1): 58-68, jan 2014.

Siracusa MC, Saenz SA, Wojno ED, Kim BS, Osborne LC, Ziegler CG, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR, Artis D.: Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity 39(6): 1158-70, December 2013.

Ong BA, Li J, McDonough JM, Wei Z, Kim C, Chiavacci R, Mentch F, Caboot JB, Spergel J, Allen JL, Sleiman PM, Hakonarson H.: Gene network analysis in a pediatric cohort identifies novel lung function genes. PloS One 8(9), September 2013.

Cianferoni Antonella, Khullar Karishma, Saltzman Rushani, Fiedler Joel, Garrett Jackie P, Naimi David R, Spergel Jonathan M: Oral food challenge to wheat: a near-fatal anaphylaxis and review of 93 food challenges in children. The World Allergy Organization journal 6(1): 14, Aug 2013.

Noti Mario, Wojno Elia D Tait, Kim Brian S, Siracusa Mark C, Giacomin Paul R, Nair Meera G, Benitez Alain J, Ruymann Kathryn R, Muir Amanda B, Hill David A, Chikwava Kudakwashe R, Moghaddam Amin E, Sattentau Quentin J, Alex Aneesh, Zhou Chao, Yearley Jennifer H, Menard-Katcher Paul, Kubo Masato, Obata-Ninomiya Kazushige, Karasuyama Hajime, Comeau Michael R, Brown-Whitehorn Terri, de Waal Malefyt Rene, Sleiman Patrick M, Hakonarson Hakon, Cianferoni Antonella, Falk Gary W, Wang Mei-Lun, Spergel Jonathan M, Artis David: Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nature medicine 19(8): 1005-13, Aug 2013.

Ruffner Melanie A, Ruymann Kathryn, Barni Simona, Cianferoni Antonella, Brown-Whitehorn Terri, Spergel Jonathan M: Food Protein-induced Enterocolitis Syndrome: Insights from Review of a Large Referral Population. The journal of allergy and clinical immunology. In practice 1(4): 343-9, Jul-Aug 2013.

Franciosi James P, Hommel Kevin A, Bendo Cristiane B, King Eileen C, Collins Margaret H, Eby Michael D, Marsolo Keith, Abonia J Pablo, von Tiehl Karl F, Putnam Philip E, Greenler Alexandria J, Greenberg Allison B, Bryson Ronald A, Davis Carla M, Olive Anthony P, Gupta Sandeep K, Erwin Elizabeth A, Klinnert Mary D, Spergel Jonathan M, Denham Jolanda M, Furuta Glenn T, Rothenberg Marc E, Varni James W: PedsQL eosinophilic esophagitis module: feasibility, reliability, and validity. Journal of pediatric gastroenterology and nutrition 57(1): 57-66, Jul 2013.

Lee Juhee, Garrett Jackie P-D, Brown-Whitehorn Terri, Spergel Jonathan M: Biphasic reactions in children undergoing oral food challenges. Allergy and asthma proceedings : the official journal of regional and state allergy societies 34(3): 220-6, May-Jun 2013.

Muir Amanda B, Lim Diana M, Benitez Alain J, Modayur Chandramouleeswaran Prasanna, Lee Anna J, Ruchelli Eduardo D, Spergel Jonathan M, Wang Mei-Lun: Esophageal epithelial and mesenchymal cross-talk leads to features of epithelial to mesenchymal transition in vitro. Experimental cell research 319(6): 850-9, Apr 2013.

Fung Irene, Kim Jennifer S, Spergel Jonathan M: Relating microarray component testing and reported food allergy and food-triggered atopic dermatitis: a real-world analysis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 110(3): 173-177.e1, Mar 2013.

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Last updated: 03/10/2014
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