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Felix Werner Wehrli, Ph.D.

Felix Werner Wehrli, Ph.D.

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Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
University of Pennsylvania
Department of Radiology
1 Founders Pavilion
MRI Education Center
3400 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-7951
Fax: (215) 662-7263
Lab: (215) 349-8519
Education:
M.S. (Chemistry)
Swiss Federal Institute of Technology , 1967.
Ph.D. (Chemistry)
Swiss Federal Institute of Technology, 1970.
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Description of Research Expertise

Research of the Laboratory for Structural NMR Imaging is aimed at quantitatively characterizing tissue microarchitecture and its relationship to physiology and function by means of spatially resolved nuclear magnetic resonance in animals and humans.

A major focus of the Laboratory is the development of new methods for the quantitative assessment of metabolic bone disease by means of the MR-based "virtual bone biopsy" and image-based computational biomechanics. A related area of concentration is the reduction to practice and translation to the clinic of novel quantitative solid-state proton and phosphorus MRI techniques for the study of bone matrix and mineral properties. A further line of work focuses on the quantification of systemic vascular disease via functional MRI-based methods including time-resolved blood flow, vascular compliance and venous blood oximetry with applications to the peripheral and central vascular system

Other areas of active in-house and collaborative research comprise the further development of novel non-Cartesian imaging techniques for cancer staging in the abdomen and chest, research aimed at the study of gene expression in mouse models of disease using novel micro-CT approaches, the study of neuronal architecture in mouse models of spinal cord injury by means of diffusion diffraction NMR, the development of MRI techniques to map internal strains of the intervertebral disc, and the development of novel RF coil hardware for ultra-high field MRI. Investigators in the lab have also recently embarked on a program aimed to develop and implement methods for imaging with real-time feedback control applied to fMRI of drug addiction and treatment.

Selected Publications

Rebuzzi Mauro, Vinicola Vincenzo, Taggi Franco, Sabatini Umberto, Wehrli Felix W, Capuani Silvia: Potential Diagnostic Role of the MRI-Derived Internal Magnetic Field Gradient in Calcaneus Cancellous Bone for Evaluating Postmenopausal Osteoporosis at 3T. Bone Jul 2013.

Rodgers Zachary B, Jain Varsha, Englund Erin K, Langham Michael C, Wehrli Felix W: High temporal resolution MRI quantification of global cerebral metabolic rate of oxygen consumption in response to apneic challenge. Journal of Cerebral Blood Flow and Metabolism Jul 2013.

Zhang Ning, Magland Jeremy F, Rajapakse Chamith S, Bhagat Yusuf A, Wehrli Felix W: Potential of in vivo MRI-based nonlinear finite-element analysis for the assessment of trabecular bone post-yield properties. Medical Physics 40(5): 052303, May 2013.

Seifert Alan C, Wright Alexander C, Wehrli Suzanne L, Ong Henry H, Li Cheng, Wehrli Felix W: (31) P NMR relaxation of cortical bone mineral at multiple magnetic field strengths and levels of demineralization. NMR in Biomedicine Mar 2013.

Langham Michael C, Englund Erin K, Mohler Emile R, Li Cheng, Rodgers Zachary B, Floyd Thomas F, Wehrli Felix W: Quantitative CMR markers of impaired vascular reactivity associated with age and peripheral artery disease. Journal of Cardiovascular Magnetic Resonance 15: 17, 2013.

Jain Varsha, Magland Jeremy, Langham Michael, Wehrli Felix W: High temporal resolution in vivo blood oximetry via projection-based T(2) measurement. Magnetic Resonance in Medicine Oct 2012.

Li Cheng, Magland Jeremy F, Rad Hamidreza Saligheh, Song Hee Kwon, Wehrli Felix W: Comparison of optimized soft-tissue suppression schemes for ultrashort echo time MRI. Magnetic Resonance in Medicine 68(3): 680-9, Sep 2012.

Jain Varsha, Abdulmalik Osheiza, Propert Kathleen Joy, Wehrli Felix W: Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification. Magnetic Resonance in Medicine 68(3): 863-7, Sep 2012.

Wald Michael J, Magland Jeremy F, Rajapakse Chamith S, Bhagat Yusuf A, Wehrli Felix W: Predicting trabecular bone elastic properties from measures of bone volume fraction and fabric on the basis of micromagnetic resonance images. Magnetic Resonance in Medicine 68(2): 463-73, Aug 2012.

Ong Henry H, Wright Alexander C, Wehrli Felix W: Deuterium nuclear magnetic resonance unambiguously quantifies pore and collagen-bound water in cortical bone. Journal of Bone and Mineral Research Jul 2012.

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Last updated: 08/09/2013
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