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Douglas B. Cines, M.D.

Douglas B. Cines, M.D.

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Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Education:
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Clinical Expertise

Coagulation. Immune hematological disorders

Selected Publications

Bao, J., Bdeir, K., Siegel, D.L., Cines, D.B. and Zheng, X.L. : Inhibition of ADAMTS13 activity by human neutrophil peptide 1 (HNP-1): potential link between inflammation, onset of thrombotic thrombocytopenic purpura, and other thrombosis. Am Soc Hematol. Dec 2014.

Hayes, V., Johnston, I., Cines, D.B., Rauova, L., Poncz, M. : New insights into the prothrombotic state of heparin-induced thrombocytopenia (HIT): The endothelial lining and “rolling barrage” of activation. Am Soc Hematol Dec 2014.

Ahn, H.-S., Fuentes, R., Hayes, V., Cines, D.B., Muzykantov, V., Zaytsev, S. and Poncz, M.: A human-specific, platelet-targeted, thrombin-activatable urokinase (PLT/uPA-T) demonstrates high thromboprophylactic properties in two in vivo models. Am Soc Hematol. Dec 2014.

Hayes, V., Johnston, I., Cines, D.B., Rauova, L., Poncz, M.: New insights into the prothrombotic state of heparin-induced thrombocytopenia (HIT): The endothelial lining and “rolling barrage” of activation. Am Soc Hematol., Dec 2014.

Madeeva, D., Tutweiler, V., Cines, D.B., Poncz, M. and Rauova. L. : Monocytes contribute to the prothrombotic nature of heparin-induced thrombocytopenia via activation through FcγRIIA. Am Soc Hematol. Dec 2014.

Cai, Z., Yarovoi, S.V., Zhu, Z., Rauova, L., Lebedeva, T., Poncz, M., Arepally, G., Cines, D.B and Greene. M.I. : Atomic level description of the immune complex that causes heparin-induced thrombocytopenia (HIT) Am Soc Hematol., Dec 2014.

Tutwiler V., Litvinov R.I., Lebedeva T., Ataullkkhanov, F.I., Cines D.B., and Weisel J.W: Effects of platelets and erythrocytes on the dynamic size and mechanical properties of blood clots during contraction. Am Soc Hematol. Dec 2014.

Lynell R. Skewis, Edward C. Thayer, Massefski, W., Papkov, V., Lowery, T.J., Lebedeva, T., Cuker, A., Abrams, C., Litvinov, R., Weisel, J.W. and Cines, D.B. : T2MR: A New Platelet Function Testing Platform. The Thrombosis and Hemostasis Summit of North America (THSNA). April 2014.

Cines, D.B., Cuker, A., and Semple, J.W: Pathogenesis of immune thrombocytopenia. Quartery Medical Rev 43(4): e49-e59, April 2014.

Armstead, W.M., Riley, J, Cines, D.B. and Higazi, A.A.-R. : PAI-1 derived peptide EEIIMD prevents hypoxia/ischemia-induced aggravation of endothelin and thromboxane induced cerebrovasoconstriction. Neuro. Critical Care 20(1): 111-8, Feb 2014.

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Last updated: 09/04/2014
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