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Douglas B. Cines, M.D.

Douglas B. Cines, M.D.

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Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Education:
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Clinical Expertise

Coagulation. Immune hematological disorders

Selected Publications

Dai, J., Hayes, V., Johnston, I., Gollomp, K., Areaplly, G.M., Cines, D.B., Poncz, M. and Raouva, L.: Dynamic redistribution of platelet factor 4 on vascular and intravascular cell surfaces: Implications for heparin-induced thrombocytopenia (HIT). ISTH. Berlin, Germany June 2017.

Cines D.B., Levine L.D.: Thrombocytopenia in pregnancy. Blood 1, June 2017 Notes: epub ahead of print. doi: https://doi.org/10.1182/blood-2017-05-781971

Andrianova, I., Hayes, V., Litvinov, R., Cines, D.B., Poncz, M., Weisel, J.W. and Rauova, L.: Pathogenic antibodies in heparin-induced thrombocytopenia (HIT) activate monocytes and induce profound membrane remodeling. ISTH. Berlin, Germany June 2017.

Johnston, I., Lopez, J, Cines, D.B., Raouva, L. and Poncz, M.: Platelet factor 4: Von Willebrand Factor Complexes: An Important Antigenic Target in Heparin-Induced Thrombocytopenia? ISTH. Berlin, Germany June 2017.

Bdeir, Kh., Mei, J., Gollomp, K., Stasiak, M., Zhou, G., Cines, D.B., Worthein, G.S., Poncz, M. and Kowalska, M.A.: Platelet-specific chemokines contribute to the pathogenesis of acute lung injury. American Journal of Respiratory Cell and Molecular Biology 56(2): 261-270, Feb 2017 Notes: PMID: 27755915.

Hayes V, Johnston I, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M.: Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. The Journal of Clinical Investigation 127(3): 1090-1098, Feb 2017 Notes: PMID: 28218620.

Villa, C., Cines, D.B., Siegel, D.L. and Muzykantov, V.: Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond. Transf. Med. Rev. 31(1): 26-35, Jan 2017 Notes: Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond.

Cuker, A., Husseinzadeh, H., Lebedeva, T., Martuano, J.E., Massefski, W., Lowery, T., Lambert, M.P., Abrams, C.S., Weisel, J.W. and Cines, D.B. : Rapid evaluation of platelet function with T2 magnetic resonance using microliter volumes of whole blood. Am. J. Clin. Pathol. 146(6): 681-693, Jan 2017 Notes: doi: 10.1093/ajcp/aqw189. PMID: 28028118.

Cines D.B., Levine L.D.: Thrombocytopenia in pregnancy. ASH Education Program. Blood 2017.

Stepanova, V., Parfyonova, Y.V., Sergilev, K.V., Holman, K.m Tsokolaeva, Z.I., Atochina-Vasserman, E.N., Teter, M., Lewis, S.P., Zaitsev, S.V., Obraztosova, K., Krymskaya, V.P, and Cines, D.B.: Inhibition of urokinase plasminogen activator reduces occurence of TSC2-null tumors in the lung in a mouse model of pulmonary LAM. Annual national meeting of the LAM foundation, Washington D.C. 2017.

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Last updated: 07/21/2017
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