Douglas B. Cines, M.D.
Douglas B. Cines, M.D.
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Fax: 215-573-2012
Email:
DCINES@MAIL.MED.UPENN.EDU
DCINES@MAIL.MED.UPENN.EDU
Education:
A.B.
New York University, 1968.
M.D.
New York University School of Medicine, 1972.
Permanent linkA.B.
New York University, 1968.
M.D.
New York University School of Medicine, 1972.
Description of Research Expertise
Thormbosis, fibrinolysis, vascular biology, immunohematologyDescription of Clinical Expertise
Coagulation. Immune hematological disordersSelected Publications
Sachais, BS, Rux, AH, Cines DB, Yarovoi SV Watson PS, Garner, LI Hinds, JL and Rux, JJ. : Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia. Blood 119(25): 5955-62, 2012.Carnemolla R, Patel KR, Zaitsev S, Cines DB, Esmon CT, and Muzykantov VR.: Quantitative analysis of thrombomodulin-mediated conversion of protein C to APC: Translation from in vitro to in vivo. J Immunol Methods. 384(1-2): 21-4, 2012.
Kapustin, A., Stepanova, V., Aniol, N., Cines D.B., Poliakov, A.. Kuo, A., Wait R., Ryzhakov, G., Parfyonova, Ye., Gursky, Y., Yanagisawa, H, Minashkin, M., Beabealashvilli, R., Vorotnikov, A., Bobik, A., and Tkachuk V. : Fibulin-5 binds urokinase plasminogen activator and mediates its chemotactic effects. J. Biochem 443(2): 491-503, 2012.
Zaitsev S., Kowalska M.A., Neyman, M., Carnemolla R., Tliba, S., Ding, B.S., Stonestrom, A., Spitzer, D., Atkinson, J., Poncz, M., Cines, D.B., Esmon, C. and Muzykantov, V.R. : Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood 119(20): 4779-85, 2012.
Armstead, W.M., Riley, J., Cines, D.B., and Higazi, A.A.R.: Combination therapy with glucagon and a novel plasminogen activator inhibitor derived peptide enhances protection against impaired cerebrovasodilation during hypotension after traumatic brain injury through inhibition of ERK and JNK MAPK. Neurol. Res. (In press). Neurol. Res. 34(6): 530-7, 2012.
Armstead, W.M., Ganguly, K., Riley, J. Zaitsev, S., Cines, D.B., Higazi, A.A.-R., and Muzykantov, V.R. : RBC-coupled tPA prevents whereas tPA augments JNK MAPK mediated impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after photothrombotic Injury. Translational Stroke Res. 3: 114-21, 2012.
Armstead, W.M., Riley, J., Yarovoi, S., Cines, D.B., Smith, D. H., Higazi, A.A.R. : tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury. J Neurotrauma 29(9): 1794-802, 2012.
Cuker, A, and Cines, D.B.: How I treat heparin-induced thrombocytopenia (HIT). Blood 119(10): 2209-2218, 2012.
Pixley RA, Espinola RG, Ghebrehiwet B, Joseph K, Kao A, Bdeir K, Cines DB, Colman RW.: Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by Surface Plasmon Resonance (BiaCore). Thromb Haemost. 105(6): 1053-9, May 2011.
Gersh, K.C., Zaitsev, S., Cines, D.B., Muzykantov, V. and Weisel, J.W: Flow-dependent channel formation in clots by RBC bound fibrinolytic. Blood 117(18): 1964-7, May 2011.