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Douglas B. Cines, M.D.

Douglas B. Cines, M.D.

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Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Education:
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Clinical Expertise

Coagulation. Immune hematological disorders

Selected Publications

Husseinzadeh, H., Cuker, A., Lebeveda, T., Massefski, W., Marturano, J., Lowery, T., Abrams, C. and Cines, D.B.: T2MR platelet analysis agrees with LTA and enables facile detection of platelet disorders in microliter volumes of blood. THSNA April 2016.

Cai Z, Zhu Z, Greene MI, Cines DB. : Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT). Autoimmun. S1568-9972(16): 30059-3, Mar 2016.

Tutwiler, V., Litvinov, R.I., Lozhkin, A. P., Pershova, A.D., Lebedeva, T., Ataullakhanov, F.I., Spiller, K.L., Cines, D.B, and Weisel, J.W. : Kinetics and mechanics of clot contraction are governed by molecular and cellular blood composition. Blood 127(1): 149-59, Jan 2016.

Tutwiler, V., Madeeva, D., Ahn, H.S., Hayes, V., Cines, D.B., Zheng, X.L., McKenzie, S., Poncz, M., and Rauova, L. : Platelet transactivation by monocytes promotes the prothrombotic state in heparin-induced thrombocytopenia. Blood 127(4): 464-72, 2016.

Villa, C., Muzykantov, V., and Cines, D.B: The emerging role for red blood cells in hemostasis: Opportunity for intervention. International Society for Blood Transfusion Science Series Science Series 11(Suppl S1): 158-164, 2016.

Fuentes, R.E., Zaitsev, S., Ahn, H.-S., Hayes, V. H., Kowalska, M.A., Lambert, M.E., Wang, Y., Siegel, D. L., Bougie, D.W., Aster, R.H., Myers, D.D., Stepanova, V., Cines, D.B., Muzykantov, V.R. and Poncz, M. : A platelet-targeted urokinase prodrug as a novel thromboprophylactic agent. J. Clin. Invest 2016.

Abu-Fanne, R., Maraga, E., Abd-Elrahman, I., Hankin, A., Blum, G., Basheer, Abdeen, S., Hijazi, N., Cines, D.B., and Higazi, A.A.-: -R --Defensin promotes vascular deposition of LDL. J. Biol. Chem 291(6): 2777-86, 2016.

Florova, G., Azghani, A.O., Karandashova, S., Schaefer, C., Yarovoi, S.V., Declerck, P.J., Cines, D.B., Idell, S., and Komissarov, A.A.: The slow rate of fibrinolysis limits inhibitor selection when targeting plasminogen activator inhibitor 1 to enhance intrapleural fibrinolytic therapy. American Thoracic Society Dec 2015.

Cines, D.B., Gernsheimer, T., Wasser, J., Godeau, B., Provan, D., Lyons, R., Altomare, I., Wang, X., and Lopez, A. : Integrated analysis of long-term safety in patients with chronic immune thrombocytopenic purpura (ITP) treated with the thrombopoetin (TPO) receptor agonist romiplostim. Int. J. Hematol. 102(3): 259-270, Sep 2015.

Cai, Z., Yarovoi, S.V., Zhu, Z., Rauova, L., Hayes, V., Lebedeva, R., Li, Q., Poncz, M., Cines, D.B.* and Greene, M.I.* (*equal contribution). : Atomic description of the immune complex that causes heparin-induced thrombocytopenia. Nature Communic. Sep 2015.

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Last updated: 07/21/2016
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