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Perelman School of Medicine at the University of Pennsylvania Advanced Search

John S. Leigh,

DECEASED

John S. Leigh

faculty photo
Department: Radiology

Contact information
B1, Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: (215) 898-2044
Fax: (215) 573-2113
Education:
B.Sc (Electrical Engineering)
University of Pennsylvania, 1961.
Ph.D. (Biophysics)
University of Pennsylvania, 1971.
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Perelman School of Medicine > Faculty > Search

Description of Research Expertise

Current Research Topics:

To develop innovative magnetic resonance (MR) and optical technologies for biomedical research. Many of these technologies are driven by both basic and clinical research collaborators in the biomedical field to address specific clinical problems and to further fundamental understanding of biophysical, physiological, structural, and functional properties of biological systems in vivo.

To investigate the use of multinuclear MR techniques to study the structural and metabolic properties of cartilage, brain, and muscle, with direct application to osteoarthritis, cognitive funtion, and muscular dystrophy.

To investigate the use of multinuclear MR to monitor, the efficacy of gene therapy and gene expression in general.

To develop and improve quantitative perfusion and diffusion imaging, in comparison to PET.

To develop innovative techniques for quantitative structural imaging of multiple organ systems. These techniques include MR of hyperpolarized gases, novel contrast generation using zero-quantum coherences, and imaging of tissue microstructure.

To focus on combining optical and MR imaging techniques for the study of neurophysiology, peripheral vascular disease, and breast cancer.

Selected Publications

Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M.A.: Spatial sensitivity and temporal response of spin echo and gradient echo bold contrast at 3 T using peak hemodynamic activation time’ Neuroimage 24(1): 216-23, 2005.

Tailor, D.R., Baumgardner, J.E., Regatte, R.R., Leigh, J.S., Reddy, R. : Proton MRI of metabolically produced H2 17O using an efficient 17O2 delivery system. Neuroimage 22(2): 611-8, 2004.

Li, L., Leigh, J.S.: Quantifying Arbitrary Magnetic Susceptibility Distributions with Magnetic Resonance. Magn Reson Med 51: 1077-82, 2004.

Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M. : Spatio-Temporal Characteristics of the BOLD Signal: Spin-Echo and Gradient-Echo fMRI at 3 T. Proceedings of the International Society for Magnetic Resonance in Medicine Meeting, Kyoto, Japan Page: 1056, 2004.

Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M. ‘: A Two Compartment Model for Spin Echo BOLD Contrast: Validation at 3 T. Proceedings of the International Society for Magnetic Resonance in Medicine Meeting, Kyoto, Japan Page: 1065, 2004.

Li, L., Leigh, J.S.: A General Methodology for Quantifying Magnetic Susceptibility with MRI. Annul Conference of the American Physical Society, Montreal, Canada 03 2004.

Rajaei, S., Baumgardnr, J., Ishii, M., Fischer, M., Emami, K., Yu, J., Lipson, D., Gefter, W., Schnall, M.D., Leigh, J.S., Rizi, R.R.: Comparison of Ventilation/Perfusion Obtained by Polarized Gas MRI with Multiple Inert Gas Elimination Technique Proceedings of the International Society for Magnetic Resonance in Medicine Meeting, Kyoto, Japan Page: 847, 2004.

Tailor DR, Roy A, Regatte RR, Charagundla SR, McLaughlin AC, Leigh JS, and Reddy R: Indirect 17O-Magnetic Resonance Imaging of Cerebral Blood Flow in Rat. Magnetic Resonance in Medicine 49(3): 479-87, 2003.

Tailor DR, Poptani H, Glickson JD, Leigh JS, and Reddy R: High-Resolution Assessment of Blood Flow in Murine RIF-1 Tumors by Monitoring Uptake of H217O with Proton T1p-Dispersion Imaging. Magnetic Resonance in Medicine 49(1): 1-6, 2003.

Chen, Y., Intes, X., Tailor, D.R., Regatte, R.R., Ma, H., Ntziachristos, V., Leigh, J.S., Reddy, R., Chance, B. : Probing rat brain oxygenation with near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI). Advances in Experimental Medicine & Biology 510: 199-20, 2003.

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Last updated: 04/21/2005
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