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Glen N. Gaulton, Ph.D.

Glen N. Gaulton, Ph.D.

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Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
University of Pennsylvania
Perelman School of Medicine
240 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6055
Office: (215) 898-2874
Fax: (215) 573-7945
Education:
B.S. (Biology, with honors)
University of California, Santa Barbara, 1974.
M.S. (Biochemistry/Molecular Biology)
University of California, Santa Barbara, 1977.
Ph.D. (Biochemistry/Molecular Biology)
University of California, Santa Barbara, 1981.
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Description of Research Expertise

Research Interest
Lymphocyte development and retroviral pathology

Keywords: Lymphocyte Development, Retrovirus Pathology, HIV-1, Imaging, Diagnostics

Research Techniques:
Molecular genetics, cell biology, imaging, diagnostics, virology, immunology

Research Summary
The interests of the Gaulton laboratory focus on an increased understanding of the molecular processes that regulate the infection and pathology of retroviruses, such as HIV, the impact of these infections on the immune system, and the detection of these infections using novel imaging and diagnostic approaches.
More specifically, the laboratory has investigated the effects of human and, as experimental models, murine retroviruses during active infection of adult, pediatric and neonatal subjects. Recent results have identified the primary mechanisms whereby retroviruses induce cell destruction through cell-cell fusion, also know as syncytia formation. The laboratory has pioneered the use of magnetic resonance imaging (MRI) techniques to detect HIV infection within cells and is now applying these techniques to in vivo, whole body imaging of active infections. Lastly, using state-of-the-art engineering technology, the laboratory is developing highly sensitive yet mobile, hand-held devices to detect HIV infection in blood. These devices are critical for diagnosing new infections, and to monitor HIV levels in patients undergoing active therapy and/or participating in vaccine trials.

Lab personnel:
Tomasz Rosmyslowicz,M.D., Sr. Research Investigator

Selected Publications

Murphy, SL, Landers, CM, Honczarenko, MJ and Gaulton, GN: Linkage of reduced receptor affinity and superinfection to pathogenesis of TR1.3 murine leukemia virus. J. Virol 80: 4601-4609, 2006.

Lin, G, Murphy, SL, Gaulton, GN, and Hoxie, JA: Modification of a viral envelope glycoprotein cell-cell fusion assay by utilizing plasmid encoded bacteriophage RNA polymerase. Journal of Virology Methods 128(1-2): 135-142, Sep 2005.

Levinson, Al, Song, D, Gaulton, GN, and Zheng: The intrathymic pathogenesis of myasthenia gravis. Clinical Development Immunology 11: 215-220, 2005.

Murphy, SL, Honczarenko, MJ, Dugger, NV, Hoffman, PM, Gaulton, GN: Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR. Journal of Virology 78: 8392 - 8399, 2004.

Chung Landers, M, Dugger, N, Quadros, M, Hoffman, PM, Gaulton, GN: Neuropathogenic murine leukemia virus TR1.3 induces selective syncytia formation of brain capillary endothelium. Virology 321: 57-64, 2004.

Rozmyslowicz, T., Majka, M., Kijowski, J., Murphy, S.L., Conover, D.O., Poncz, M., Ratajczak, J., Gaulton, G.N. and Ratajczak, M.Z.: Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS 17: 33-42, 2003.

Chung Landers, M., Dugger, N., Quadros, M., Hoffman, P. M., and Gaulton, G.N.: Neuropathogenic murine leukemia virus TR1.3 induces selective syncytia formation of primary BALB/c brain capillary endothelium. Virology in press, 2003.

Rozmyslowicz, T., Kijowski, J., Conover, D.O., Baj-Krzyworzeka, M., Reca, R., Libura, J.J., Gaulton, G.N. and Ratajczak, M.Z.: New T-lymphocytic lines for studying cell infectability by human immunodeficiency virus. Eur. J. Haematol 67: 142-151, 2001.

Majka,M., Rozmyslowicz,T., Ratajczak,J., Dobrowsky,A., Pietrzowski,Z., Gaulton,G.N.: The limited infectability by R5 HIV of CD34+ cells from thymus, cord and peripheral blood and bone marrow is explained by their ability to produce chemokines. Experimental Hematology 28: 1334-1342, 2000.

Majka, M., Rozmyslowicz, T., Honczarenko, M., Ratajczak, J., Wasik, M.A., Gaulton, G.N., and Ratajczak, M.Z.: Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines. Leukemia 14: 1821-1832, 2000.

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Last updated: 08/21/2012
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