Karuppiah Muthumani, MS., PhD
Karuppiah Muthumani, MS., PhD
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
Dept of Pathology and Lab. Medicine
505 Stellar-Chance Labs
422 Curie Blvd
Philadelphia, PA 19104
505 Stellar-Chance Labs
422 Curie Blvd
Philadelphia, PA 19104
Office: 215-746-8217
Fax: 215-573-9436
Fax: 215-573-9436
Email:
muthuman@mail.med.upenn.edu
muthuman@mail.med.upenn.edu
Publications
Education:
B.S. (Biology)
Madurai-Kamaraj University, India, 1985.
M.S. (Biology)
Madurai-Kamaraj University, India, 1989.
Ph.D. (Biology)
Madurai-Kamaraj University, India, 1996.
Permanent linkB.S. (Biology)
Madurai-Kamaraj University, India, 1985.
M.S. (Biology)
Madurai-Kamaraj University, India, 1989.
Ph.D. (Biology)
Madurai-Kamaraj University, India, 1996.
Description of Research Expertise
Viral pathogenesis of HIV-1 and Alphavirus & DNA vaccines for infectious diseases and Cancer1). Vaccine development of DNA-based vaccines for HIV-1, West Nile Virus, Dengue and Chikungunya Virus
2). Targeting negative regulatory pathways to restore anti-HIV immunity
4). Novel strategy for treating cancer using therapeutic DNA vaccines
5).Characterization of novel small immune-modulatory inhibitors to treat proinflammatory diseases.
Selected Publications
Muthumani K, Shedlock DJ, Choo DK, Fagone P, Kawalekar OU, Goodman J, Bian CB, Ramanathan AA,Atman P, Tebas P, Chattergoon MA, Choo AY, and Weiner DB.: HIV-Mediated Phosphatidylinositol 3-Kinase/Serine–Threonine Kinase Activation in APCs Leads to Programmed Death-1 Ligand Upregulation and Suppression of HIV-Specific CD8 T Cells. Journal of Immunology(19), August 2011.Chaaitanya IK, Muruganandam N, Sundaram SG, Kawalekar O, Sugunan AP, Manimunda SP, Ghosal SR, Muthumani K, Vijayachari P.: Role of Proinflammatory Cytokines and Chemokines in Chronic Arthropathy in CHIKV Infection. Viral Immunollgy 24(4): 265-271, August 2011.
Fagone P, Shedlock DJ, Bao H, Kawalekar OU, Yan J, Gupta D, Morrow MP, Patel A, Kobinger GP, Muthumani K, Weiner DB.: Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination. Gene Therapy Page: doi:10.1038/gt.2011.59, May 2011.
Shedlock DJ, Talbott KT, Cress C, Ferraro B, Tuyishme S, Mallilankaraman K, Cisper NJ, Morrow MP, Wu SJ, Kawalekar OU, Khan AS, Sardesai NY, Muthumani K, Shen H, Weiner DB.: A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge. Vaccine Page: doi:10.1016/j.vaccine.2010.12.064 January 2011.
Mallilankaraman K, Shedlock DJ, Bao H, Kawalekar OU, Fagone P, Ramanathan AR, Ferraro B, Stabenow J, Vijayachari P, Sundaram SG, Muruganandam N, Sarangan G, Srikanth P, Khan AS, Lewis MG, Kim JJ, Sardesai NY, Muthumani K and Weiner DB: A DNA vaccine against Chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates. PLOS Neglected Tropical Diseases 11(5(1)): e928, January 2011.
Srikanth P, Sarangan G, Mallilankaraman K, Nayar SA, Barani R, Mattew T, Selvaraj GF, Sheriff KA, Palani G, Muthumani K.: Molecular characterization of Chikungunya virus during an outbreak in South India. Indian J Med Microbiology 28(4): 299-302, October 2010.
Mariana, I, Kawalekar, O, Shedlock DJ,Muthumani, K, Weiner, DB: DNA vaccines for targeting bacterial infections. Expert Review of Vaccines 9(7), July 2010.
Thiboutot MM, Kannan S, Kawalekar OU, Shedlock DJ, Khan AS, Sarangan G, Srikanth P, Weiner DB, Muthumani K : Chikungunya: A potentially emerging epidemic? PLOS Neglected Tropical Diseases? PLOS Neglected Tropical Diseases 27(4(4)): e623, April 2010.
Shedlock DJ, Talbott KT, Morrow MP, Ferraro B, Hokey DA, Muthumani K, Weiner DB : Ki-67 staining for determination of rhesus macaque T cell proliferative responses ex vivo. Cytometry A 77(3): 275-284, March 2010.
Muthumani K, Lambert VM, Kawalekar O, Heller R, Kim JJ, Weiner DB, Ugen KE.: Anti-cancer activity of the HIV accessory molecule viral protein R (Vpr): Delivery as a DNA expression plasmid or biologically active peptides. Vaccine 28(8): 2005-2010, Feb 2010.