Daniel J. Licht, MD

faculty photo
Associate Professor of Neurology at the Children's Hospital of Philadelphia
Department: Neurology

Contact information
Children's Hospital of Philadelphia
Division of Pediatric Neurology
10th Floor Colket Translational Research Bldg, rm 10030
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: (267) 426-5025
Fax:
Education:
BA (Biochemistry)
New York University, 1984.
MD (Medicine)
New Jersey Medical School - UMDNJ, 1997.
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Description of Research Expertise

I am a child neurologist with expertise in the care of the critically ill. My clinical practice informs my research endeavors as I try to understand how the delivery of care affects cerebral blood flow and brain metabolic use of oxygen. My research uses non-invasive imaging techniques, including MRI and Optics, which, when combined, offer both high anatomic resolution and time sensitivity.

As a consequence of my research in infants with severe congenital heart defects, I have begun exploring fetal research. I have developed an MRI technique to qualitatively assess fetal brain development as a tool to monitor fetal brain health. This is now being used to monitor a drug trial for a neuroprotective agent for fetuses identified with severe congenital heart defects. I am currently leading research to non-invasively image placental anatomy and function.

Description of Clinical Expertise

My clinical expertise is in the neurological care for children who are critically ill. I am the neurology liaison to the cardiac intensive care unit and am a consult attending for the Neonatal, Pediatric and Cardiac intensive care units. My special interests are the neurologic complications in the care of congenital cardiac disease and I am also an expert in pediatric stroke and founding member of the pediatric stroke team at CHOP.

As a consequence of caring for critically ill children, I am also a palliative care provider and attending on the Pediatric Advanced Care Team at CHOP. The PACT team is a multidisciplinary palliative care team with a directive to provide symptom relief at the end of life, with a goal of achieving the best quality of life in the face of terminal illness.

My interests in congenital malformations including congenital heart defects and congenital diaphragmatic hernia, have recently led me to the relatively new field of Fetal Neurology. I am currently the only neurologist to perform Fetal Neurology consults to optimize the care for infants with congenital malformations.

Selected Publications

Szwast Anita, Putt Mary, Gaynor J William, Licht Daniel, Rychik Jack: Cerebrovascular Response to Maternal Hyperoxygenation (MH) in Fetuses with Hypoplastic Left Heart Syndrome (HLHS) Depends Upon Gestational Age (GA) and Baseline Cerebrovascular Resistance. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Oct 2017.

Antiel Ryan M, Lin Nan, Licht Daniel J, Hoffman Casey, Waqar Lindsay, Xiao Rui, Monos Stylianos, D'Agostino Jo Ann, Bernbaum Judy, Herkert Lisa M, Rintoul Natalie E, Peranteau William H, Flake Alan W, Adzick N Scott, Hedrick Holly L: Growth trajectory and neurodevelopmental outcome in infants with congenital diaphragmatic hernia. Journal of pediatric surgery Sep 2017.

Smith Brendan, Vu Eric, Kibler Kathleen, Rusin Craig, Easley Ronald B, Andropoulos Dean, Heinle Jeffrey, Czosnyka Marek, Licht Daniel, Lynch Jennifer, Brady Ken: Does hypothermia impair cerebrovascular autoregulation in neonates during cardiopulmonary bypass? Paediatric anaesthesia 27(9): 905-910, Jun 2017.

Baker Wesley B, Parthasarathy Ashwin B, Gannon Kimberly P, Kavuri Venkaiah C, Busch David R, Abramson Kenneth, He Lian, Mesquita Rickson C, Mullen Michael T, Detre John A, Greenberg Joel H, Licht Daniel J, Balu Ramani, Kofke W Andrew, Yodh Arjun G: Noninvasive optical monitoring of critical closing pressure and arteriole compliance in human subjects. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37(8): 271678X17709166, Jan 2017.

Billinghurst Lori L, Beslow Lauren A, Abend Nicholas S, Uohara Michael, Jastrzab Laura, Licht Daniel J, Ichord Rebecca N: Incidence and predictors of epilepsy after pediatric arterial ischemic stroke. Neurology 88(7): 630-637, Jan 2017.

Lin Jainn-Jim, Banwell Brenda L, Berg Robert A, Dlugos Dennis J, Ichord Rebecca N, Kilbaugh Todd J, Kirsch Roxanne E, Kirschen Matthew P, Licht Daniel J, Massey Shavonne L, Naim Maryam Y, Rintoul Natalie E, Topjian Alexis A, Abend Nicholas S: Electrographic Seizures in Children and Neonates Undergoing Extracorporeal Membrane Oxygenation. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 18(3): 249-257, Jan 2017.

Uohara Michael Y, Beslow Lauren A, Billinghurst Lori, Jones Brianna M, Kessler Sudha K, Licht Daniel J, Ichord Rebecca N: Incidence of Recurrence in Posterior Circulation Childhood Arterial Ischemic Stroke. JAMA neurology 74(3): 316-323, Jan 2017.

Fogel Mark A, Li Christine J, Elci Okan U, Pawlowski Tom, Schwab Peter J, Wilson Felice B, Nicolson Susan C, Montenegro Lisa M, Diaz Laura, Spray Thomas L, Gaynor J William, Fuller Stephanie, Mascio Christopher E, Keller Marc S, Harris Matthew A, Whitehead Kevin K, Bethel James, Vossough Arastoo, Licht Daniel J: Neurologic Injury and Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction. Circulation 135(7): 671-682, Dec 2016.

Ouyang Minhui, Liu Peiying, Jeon Tina, Chalak Lina, Heyne Roy, Rollins Nancy K, Licht Daniel J, Detre John A, Roberts Timothy P L, Lu Hanzhang, Huang Hao: Heterogeneous increases of regional cerebral blood flow during preterm brain development: Preliminary assessment with pseudo-continuous arterial spin labeled perfusion MRI. NeuroImage 147: 233-242, Dec 2016.

Busch David R, Rusin Craig G, Miller-Hance Wanda, Kibler Kathy, Baker Wesley B, Heinle Jeffrey S, Fraser Charles D, Yodh Arjun G, Licht Daniel J, Brady Kenneth M: Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest. Biomedical optics express 7(9): 3461-3470, Sep 2016.

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Last updated: 12/11/2017
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