Sergei V. Zaytsev, Ph.D.
Sergei V. Zaytsev, Ph.D.
Research Assistant Professor of Pharmacology
Department: Pharmacology
Contact information
Institute for Translational Medicine and Therapeutics
University of Pennsylvania School of Medicine
823 BRB II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
University of Pennsylvania School of Medicine
823 BRB II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 740-8970
Fax: (215) 898-0868
Fax: (215) 898-0868
Email:
zaytsev@mail.med.upenn.edu
zaytsev@mail.med.upenn.edu
Education:
M.S. (Physics/Biophysics)
St. Petersburg State University, Russia, 1992.
Ph.D. (Biology)
Institute of Cytology, Russian Academy of Sciences, 2000.
Permanent linkM.S. (Physics/Biophysics)
St. Petersburg State University, Russia, 1992.
Ph.D. (Biology)
Institute of Cytology, Russian Academy of Sciences, 2000.
Selected Publications
Armstead WM, Ganguly K, Riley J, Kiessling JW, Cines DB, Higazi AA, Zaitsev S, Muzykantov VR: Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig. Pediatr Crit Care Med 2011 (In Press).Gersh KC, Zaitsev S, Muzykantov V, Cines DB, Weisel JW: The spatial dynamics of fibrin clot dissolution catalyzed by erythrocyte-bound vs. free fibrinolytics. J Thromb Haemost 8(5): 1066-1074, 2010.
Armstead WM, Ganguly K, Kiessling JW, Riley J, Chen XH, Smith DH, Stein SC, Higazi AA, Cines DB, Bdeir K, Zaitsev S, Muzykantov VR: Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders (Review). J Neurochem 113(2): 303-312, 2010 Notes: [Erratum in: J Pharmacol Exp Ther 333(3): 976, 2010. Zaytzev, Sergei corrected to Zaitsev, Sergei]:
Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Marcos-Contreras OA, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR: Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood 115(25): 5241-5248, 2010.
Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Bdeir K, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR: Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther 332(3): 1022-1031, 2009 Notes: [Erratum in: J Pharmacol Exp Ther 333(3): 976, 2010. Zaytzev, Sergei corrected to Zaitsev, Sergei]
Haberland A, Zaitsev S, Waldöfner N, Erdmann B, Böttger M, Henke W: Structural appearance of linker histone H1/siRNA complexes. Mol Biol Rep 36(5): 1083-1093, 2009.
Armstead WM, Ganguly K, Kiessling JW, Chen XH, Smith DH, Higazi AA, Cines DB, Bdeir K, Zaitsev S, Muzykantov VR: Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation. J Cereb Blood Flow Metab 29(8): 1463-1474, 2009.
Danielyan K, Ganguly K, Ding BS, Atochin D, Zaitsev S, Murciano JC, Huang PL, Kasner SE, Cines DB, Muzykantov VR: Cerebrovascular thromboprophylaxis in mice by erythrocyte-coupled tissue-type plasminogen activator. Circulation 118(14): 1442-1449, 2008.
Stepanova V, Lebedeva T, Kuo A, Yarovoi S, Tkachuk S, Zaitsev S, Bdeir K, Dumler I, Marks MS, Parfyonova Y, Tkachuk VA, Higazi AA, Cines DB: Nuclear translocation of urokinase-type plasminogen activator. Blood 112(1): 100-110, 2008.
Zaitseva I, Zaitsev S, Alenina N, Bader M, Krivokharchenko A: Dynamics of DNA-demethylation in early mouse and rat embryos developed in vivo and in vitro. Mol Reprod Dev 74(10): 1255-1261, 2007.