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Sergei V. Zaytsev, Ph.D.

Sergei V. Zaytsev, Ph.D.

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Research Assistant Professor of Pharmacology
Department: Pharmacology

Contact information
Institute for Translational Medicine and Therapeutics
University of Pennsylvania School of Medicine
823 BRB II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 740-8970
Fax: (215) 898-0868
Education:
M.S. (Physics/Biophysics)
St. Petersburg State University, Russia, 1992.
Ph.D. (Biology)
Institute of Cytology, Russian Academy of Sciences, 2000.
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Selected Publications

Armstead WM, Ganguly K, Riley J, Kiessling JW, Cines DB, Higazi AA, Zaitsev S, Muzykantov VR: Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig. Pediatr Crit Care Med 2011 (In Press).

Gersh KC, Zaitsev S, Muzykantov V, Cines DB, Weisel JW: The spatial dynamics of fibrin clot dissolution catalyzed by erythrocyte-bound vs. free fibrinolytics. J Thromb Haemost 8(5): 1066-1074, 2010.

Armstead WM, Ganguly K, Kiessling JW, Riley J, Chen XH, Smith DH, Stein SC, Higazi AA, Cines DB, Bdeir K, Zaitsev S, Muzykantov VR: Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders (Review). J Neurochem 113(2): 303-312, 2010 Notes: [Erratum in: J Pharmacol Exp Ther 333(3): 976, 2010. Zaytzev, Sergei corrected to Zaitsev, Sergei]:

Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Marcos-Contreras OA, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR: Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood 115(25): 5241-5248, 2010.

Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Bdeir K, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR: Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther 332(3): 1022-1031, 2009 Notes: [Erratum in: J Pharmacol Exp Ther 333(3): 976, 2010. Zaytzev, Sergei corrected to Zaitsev, Sergei]

Haberland A, Zaitsev S, Waldöfner N, Erdmann B, Böttger M, Henke W: Structural appearance of linker histone H1/siRNA complexes. Mol Biol Rep 36(5): 1083-1093, 2009.

Armstead WM, Ganguly K, Kiessling JW, Chen XH, Smith DH, Higazi AA, Cines DB, Bdeir K, Zaitsev S, Muzykantov VR: Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation. J Cereb Blood Flow Metab 29(8): 1463-1474, 2009.

Danielyan K, Ganguly K, Ding BS, Atochin D, Zaitsev S, Murciano JC, Huang PL, Kasner SE, Cines DB, Muzykantov VR: Cerebrovascular thromboprophylaxis in mice by erythrocyte-coupled tissue-type plasminogen activator. Circulation 118(14): 1442-1449, 2008.

Stepanova V, Lebedeva T, Kuo A, Yarovoi S, Tkachuk S, Zaitsev S, Bdeir K, Dumler I, Marks MS, Parfyonova Y, Tkachuk VA, Higazi AA, Cines DB: Nuclear translocation of urokinase-type plasminogen activator. Blood 112(1): 100-110, 2008.

Zaitseva I, Zaitsev S, Alenina N, Bader M, Krivokharchenko A: Dynamics of DNA-demethylation in early mouse and rat embryos developed in vivo and in vitro. Mol Reprod Dev 74(10): 1255-1261, 2007.

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Last updated: 01/07/2011
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