Sriram Krishnaswamy, Ph.D.
Sriram Krishnaswamy, Ph.D.
Professor of Pediatrics
Department: Pediatrics
Contact information
Joseph Stokes Research Institute / CHOP
310 Abramson
3516 Civic Center Blvd.
Philadelphia, PA 19104
310 Abramson
3516 Civic Center Blvd.
Philadelphia, PA 19104
Office: (215) 590-3346
Fax: (215) 590-2320
Fax: (215) 590-2320
Email:
skrishna@mail.med.upenn.edu
skrishna@mail.med.upenn.edu
Publications
Education:
BS (Biology)
Syracuse University, 1979.
Ph.D. (Biochemistry)
Syracuse University, 1984.
Permanent linkBS (Biology)
Syracuse University, 1979.
Ph.D. (Biochemistry)
Syracuse University, 1984.
Selected Publications
Wilkens, M. and and Krishnaswamy, S: The contribution of factor Xa to exosite-dependent substrate recognition by prothrombinase. J. Biol. Chem 277: 9366-9374, 2002.Buddai, S.K., Toulokhonova, L., Bergum, P.W., Vlasuk, G.P. and Krishnaswamy, S: Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase. J. Biol. Chem 277: 26689-26698, 2002.
Venkateswarlu, D., Krishnaswamy, S., Darden, T.A., and Pedersen, L.G: Three-dimensional solution structure of Tropidechis carinatus venom extract trocarin: a structural homologue of Xa and prothrombin activator. J. Mol. Model 8: 302-313, 2002.
Orcutt, S., Pietropaolo, C. and Krishnaswamy, S: Extended Interactions with the Macromolecular Substrate Enforce Affinity and Specificity in Prothrombinase Function. J. Biol. Chem 277: 46191-46196, 2002.
Krishnaswamy, S: Inside Blood-Clotting in whole blood: analysis of a biochemical reaction network. Blood 100: 1, 2002.
Wilkens, M., Broze, G.J., Vlasuk, G.P. and Krishnaswamy, S: Contribution of extended interactions to substrate and inhibitor specificity of human Xa. 2002 Notes: In preparation.
Boskovic, D. and Krishnaswamy, S: Active site-independent binding of the protein substrate to prothrombinase. An assessment by fluorescence resonance energy transfer. 2002 Notes: in preparation.
Krishnaswamy, S: Mechanisms of macromolecular substrate specificity and recognition in blood coagulation. Blood 2002 Notes: in preparation.
Buddai, S.K., Wilkens, M., Bergum, P.W., Vlasuk, G.P. and Krishnaswamy, S: Recombinant Nematode Anticoagulant Peptide c2 reveals a domain on Factor Xa that is important for macromolecular substrate and inhibitor recognition. Thromb. Hemostas 2001 Notes: oral presentation.
Krishnaswamy, S., Broze, G.J., Vlasuk, G.P. and Wilkens, M: Exosite-binding contributes significantly to the potent inhibition of factor Xa by Tissue Factor Pathway Inhibitor. Blood 98: 528a, 2001 Notes: poster presentation.