Gary Koretzky, MD, PhD
Gary Koretzky, MD, PhD
Francis C. Wood Professor
Department: Medicine
Graduate Group Affiliations
Contact information
415 BRB II/III
421 Curie Blvd
University of Pennsylvania
School of Medicine
Philadelphia, PA 19104
421 Curie Blvd
University of Pennsylvania
School of Medicine
Philadelphia, PA 19104
Office: (215) 746-5522
Fax: (215) 746-5525
Fax: (215) 746-5525
Email:
koretzky@mail.med.upenn.edu
koretzky@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Immunological Reviews
Cell and Molecular Biology graduate group faculty webpage.
Immunology graduate group faculty webpage.
School of Medicine Website
Primary Work Website
Search PubMed for articles
Immunological Reviews
Cell and Molecular Biology graduate group faculty webpage.
Immunology graduate group faculty webpage.
School of Medicine Website
Primary Work Website
Education:
A.B.
Cornell University , 1978.
Ph.D.
University of Pennsylvania , 1984.
M.D.
University of Pennsylvania , 1984.
Masters (Masters of Arts, Honorary)
University of Pennsylvania, 1999.
Permanent linkA.B.
Cornell University , 1978.
Ph.D.
University of Pennsylvania , 1984.
M.D.
University of Pennsylvania , 1984.
Masters (Masters of Arts, Honorary)
University of Pennsylvania, 1999.
Description of Research Expertise
Research Interests- Role of adapter proteins in immune cell development and function
- Signals leading to T cell activation and termination of T cell responses
- In vitro and in vivo function of mast cells and neutrophils
Key words: signal transduction, adapter proteins, SLP-76, DGK-zeta, T-cell activation, TCR signaling.
Description of Research
Our laboratory studies the regulation of signaling events that lead to hematopoietic cell development and function. We make extensive use of genetically altered mice for these studies. To date, we have identified three novel adapter proteins and have made mice deficient in each of these molecules. We have also investigated the role of enzymes by targeted gene deletion. Collectively these studies have provided new insights into how these proteins serve as regulators of multiple lineages in the hematopoietic system.
Rotation Projects
Studies of the molecular and biochemical role of adapter proteins in hematopoietic cell development and growth.
Lab personnel:
Rohan Joshi (Graduate Student)
Jiyeon Kim (Graduate Student)
Rebecca May (Graduate Student)
Tao Zou (Graduate Student)
Shannon Carty, MD (Fellow)
Alyssa Johnsen, MD, PhD (Instructor, Department of Medicine)
Martha Jordan, PhD (Research Assistant Professor of Pathology & Laboratory Medicine)
Scott Lieberman, MD, PhD (Fellow)
Mathew Riese, MD, PhD (Fellow)
Mercy Gohil (Laboratory Manager)
Jashanpreet Grewal (Research Specialist)
Justina Stadanlick (Executive Assistant)
Selected Publications
Baker RG, Hsu CJ, Lee D, Jordan MS, Maltzman JS, Hammer DA, Baumgart T, Koretzky GA.: The adapter protein SLP-76 mediates “outside-in” integrin signaling and function in T cells. Mol Cell Biol. 29(20): 5578-89, Oct 2009 Notes: Epub 2009 Aug 10.Bezman NA, Lian L, Abrams CS, Brass LF, Kahn ML, Jordan MS, Koretzky GA.: Requirements of SLP-76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. J Exper Med. 205(8): 1775-1788, Aug 2008 Notes: Epub 2008 Jul 28.
Juntilla MA, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA.: Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci USA. 104(29): 12105-10, Jul 2007 Notes: Epub 2007 Jul 3.
Menasche G, Kliche S, Chen EJH, Stradal TEB, Schraven B, Koretzky GA.: RIAM links the ADAP/SKAP-55 signaling module to Rap1 facilitating TCR-mediated integrin activation. Mol Cell Biol. (eds.). 27(11): 4070-81, Jan 2007 Notes: Epub 2007 Apr 2.
Olenchock BA, Guo R, Silverman MA, Wu JN, Carpenter JH, Koretzky GA, Zhong X-P.: Impaired degranulation but enhanced cytokine production following FcepsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. J Exp Med. 203(6): 1471-80, Jun 2006 Notes: Epub 2006 May 22.
Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA.: Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol. 26(18): 6936-49, Sep 2006.
Maltzman JS, Kovoor L, Clements JL, Koretzky GA.: Conditional deletion of SLP-76 reveals a cell autonomous requirement for T cell lineage commitment. J Exp Med. (eds.). 202(7): 893-900, Oct 2005 Notes: Epub 2005 Sep 26.
Silverman MA, Shoag J, Wu J, Koretzky GA.: Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol. 26(5): 1826-1838, Mar 2005.